公开(公告)号：US20220257725A1

公开(公告)日：2022-08-18

申请号：US17625514

申请日：2020-07-10

Applicant: University of Utah Research Foundation

Inventor： Esther Nuebel ,  Jared Rutter ,  Yu-Chan Chen ,  Joshua Bonkowsky

IPC: A61K38/46 ,  A61K31/197 ,  A61K31/4015 ,  A61P3/00

Abstract: Disclosed herein are compositions and methods for treating mitochondrial dysfunction. The methods can include compositions capable of increasing or overexpressing ATAD1. The methods include restoring mitochondrial respiration and ATP production. The present disclosure provides a mechanism for peroxin (peroxisomal biogenesis factors) accumulation on mitochondria that affects respiration and ATP generation.

公开(公告)号：US20220251510A1

公开(公告)日：2022-08-11

申请号：US17721690

申请日：2022-04-15

Applicant: University of Utah Research Foundation

Inventor： Tara L. Deans

IPC: C12N5/078 ,  C12N5/0789 ,  C12N15/85

Abstract: Disclosed herein are methods of producing platelets and red blood cells using synthetic biology and uses thereof. The methods disclosed herein can also be used to produce platelets and red blood cells comprising a therapeutic agent. The cells produced by the methods disclosed herein can be used to treat, manage, prevent and diagnosis various diseases and disorders and be used as a research tool.

公开(公告)号：US11339173B2

公开(公告)日：2022-05-24

申请号：US17023323

申请日：2020-09-16

Applicant: University of Utah Research Foundation

Inventor： Darrell Davis ,  Shuanghu Liu

IPC: C07D491/147 ,  C07D487/04 ,  C07D235/30 ,  C07D491/048 ,  C07D491/052 ,  C07D495/14

Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20220151950A1

公开(公告)日：2022-05-19

申请号：US17099224

申请日：2020-11-16

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Robert Z. Tashjian ,  Peter N. Chalmers ,  T. Wade Fallin ,  James M. Hotaling

IPC: A61K31/05 ,  A61P21/00 ,  A61P19/00 ,  A61K45/06 ,  A61L17/00 ,  A61K9/70

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

公开(公告)号：US11324801B2

公开(公告)日：2022-05-10

申请号：US16908250

申请日：2020-06-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Christian Con Yost ,  Guy A. Zimmerman ,  Andrew S. Weyrich ,  Joshua Schiffman

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/47 ,  A61P29/00 ,  A61P35/04

Abstract: Neonatal NET-inhibitory Factor (nNIF) and nNIF-Related Peptides (NRPs) are provided. Methods for the treatment of and prophylaxis against inflammatory disorders and cancer are also provided. Additionally, methods for the inhibition of metastasis in patients having cancer are provided. The methods can include administering nNIF and/or a NRP to patients having, or at risk of developing, an inflammatory disorder or a cancer.

公开(公告)号：US20220112268A1

公开(公告)日：2022-04-14

申请号：US17549367

申请日：2021-12-13

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao

IPC: C07K14/78 ,  A61K38/16 ,  A61K39/395 ,  A61K9/51 ,  A61K39/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/39 ,  A61K9/107 ,  A61K9/00 ,  A61K47/34 ,  A61K38/39 ,  C07K14/36

Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.

公开(公告)号：US20220104724A1

公开(公告)日：2022-04-07

申请号：US17419133

申请日：2020-01-07

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Lara M. Brewer CATES ,  Robert J. FARNEY ,  Sean C. ERMER ,  Joseph A. ORR

IPC: A61B5/08 ,  A61B5/00 ,  G16H50/30 ,  G16H50/20

Abstract: A computer system receives sensor measurements from a respiration sensor. The computer system generates a particular set of data features from the sensor measurements. The computer system then processes the particular set of data features through a computer-based ataxic breathing rating algorithm. The computer system displays on a user interface an ataxic breathing rating that is calculated from the computer-based ataxic breathing rating algorithm.

公开(公告)号：US11293028B2

公开(公告)日：2022-04-05

申请号：US15765132

申请日：2016-10-03

Applicant: University of Utah Research Foundation

Inventor： Kelly T. Hughes ,  Fabienne Chevance

IPC: C12N15/00 ,  C12N15/74 ,  C07K14/62 ,  C07K14/245

Abstract: The present invention relates to the effects of codon context and synonymous codon changes on mRNA translation and methods of increasing protein production.

公开(公告)号：US11266801B2

公开(公告)日：2022-03-08

申请号：US15767094

申请日：2016-10-07

Applicant: University of Utah Research Foundation

Inventor： Michael Fogarty ,  Joseph Orr ,  Kai Kuck

IPC: A61M16/00 ,  A61M16/06 ,  A61M16/01 ,  A61M16/12

Abstract: A ventilation system having a mask, a blowing assembly, and a processor. The mask has a mask body and a pressure sensor operatively associated with the mask body and configured to measure pressure within the mask. The mask body defines an inlet opening and a plurality of leak openings. The blowing assembly is positioned in fluid communication with the inlet opening of the mask body and configured to direct air to the inlet opening of the mask body. The processor is positioned in operative communication with the blowing assembly and the pressure sensor of the mask. The processor is configured to selectively control the blowing assembly based upon at least the measured pressure within the mask.

公开(公告)号：US20220054662A1

公开(公告)日：2022-02-24

申请号：US17379402

申请日：2021-07-19

Applicant: University of Utah Research Foundation

Inventor： Leonard F. Pease ,  Hedieh Saffari ,  Gerald J. Gleich ,  Kristin M. Leiferman ,  Kathryn A. Peterson ,  Russell Morris Condie

IPC: A61K51/04 ,  A61K51/08

Abstract: Also disclosed are methods