公开(公告)号：US07560036B2

公开(公告)日：2009-07-14

申请号：US11133245

申请日：2005-05-20

Applicant: Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

Inventor： Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

IPC: A61B17/20

CPC classification number: B81C1/00111 ,  A61B17/205 ,  A61B2017/00526 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

Abstract: The invention relates to a method of fabricating a microneedle array in a substrate, a drug delivery device comprising one or more microneedles extending upwards from the front surface of the substrate, the microneedles having a generally conical-shaped body defined by a plurality of surfaces sloping upwards from a relatively broad base to a tip, and one or more substances coating the microneedles, the one or more substances being operable to be administered to a patient, wherein the tips of the one or more microneedles are sufficiently sharp to penetrate an outer layer of the skin of the patient, and a method of administering one or more substances to a patient using the device.

Abstract translation: 本发明涉及一种在衬底中制造微针阵列的方法，药物递送装置包括从衬底的前表面向上延伸的一个或多个微针，所述微针具有由倾斜的多个表面限定的大致圆锥形体 从相对宽的基部向上延伸至尖端，以及一种或多种涂覆微针的物质，所述一种或多种物质可操作地施用于患者，其中所述一个或多个微针的尖端足够锋利以穿透外层 的患者皮肤，以及使用该装置向患者施用一种或多种物质的方法。

公开(公告)号：US20090162798A1

公开(公告)日：2009-06-25

申请号：US12379308

申请日：2009-02-18

Applicant: Takao Tomono

Inventor： Takao Tomono

IPC: G03F7/20 ,  B32B3/10 ,  B29C33/00 ,  G03B27/52

CPC classification number: B81C1/00111 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B81B2201/055 ,  G03F7/201 ,  G03F7/2022 ,  Y10T428/24479

Abstract: A method of manufacturing a master plate includes the steps of forming a photoresist film on a substrate, disposing a photomask having a plurality of island radiation shields on the photoresist film followed by integrating the photomask and the photoresist film, applying light from a light source to the photoresist film through the photomask for selectively exposing the photoresist film, and developing the photoresist film to form a master plate, in which the method includes irradiating the photoresist film with the light from plural directions through the photomask to selectively expose the photoresist film from the respective directions.

Abstract translation: 制造母板的方法包括以下步骤：在衬底上形成光致抗蚀剂膜，将具有多个岛状辐射屏蔽的光掩模设置在光致抗蚀剂膜上，然后将光掩模和光致抗蚀剂膜整合，将来自光源的光施加到 所述光致抗蚀剂膜通过所述光掩模用于选择性地暴露所述光致抗蚀剂膜，以及显影所述光致抗蚀剂膜以形成母板，其中所述方法包括用来自多个方向的光照射所述光致抗蚀剂膜通过所述光掩模，以选择性地将所述光致抗蚀剂膜从 各自的方向。

公开(公告)号：US20090131905A1

公开(公告)日：2009-05-21

申请号：US12150945

申请日：2008-05-01

Applicant: Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

Inventor： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC: A61M5/32 ,  A61N1/32 ,  B29C45/00 ,  G03F7/20 ,  B22D23/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B33Y80/00 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

公开(公告)号：US20090093776A1

公开(公告)日：2009-04-09

申请号：US12296672

申请日：2006-08-25

Applicant: Ruifeng Yue ,  Yan Wang ,  Litian Liu

Inventor： Ruifeng Yue ,  Yan Wang ,  Litian Liu

IPC: A61M5/32 ,  A61B17/32 ,  B44C1/22

CPC classification number: A61B17/3211 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B10/0045 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2205/0244 ,  B81B1/008 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention discloses a linear-edged 3D solid or hollow microneedle or microknife. A tip edge of the microneedle or microknife is a linear edge parallel to a group of (111) oriented facets of monocrystalline silicon. The linear edge extends along a straight or curved line and has a narrow width. An opening is formed on one or each side adjoining the linear tip edge, or is formed at the middle of the linear tip edge. The opening is communicated with a channel formed from the bottom surface of the microneedle or microknife, so as to form a through hole from the tip to the bottom of the microneedle or microknife. The triangular channel has six side walls of (111) oriented facets. The microneedle or microknife is used for transdermal drug delivery, body fluid withdrawing or the like. Methods for producing a microneedle or microknife are also disclosed.

Abstract translation: 本发明公开了一种线性边缘3D实心或中空微针或微刀。 微针或微刀的尖端边缘是平行于一组（111）单晶硅定向小面的线性边缘。 线性边缘沿直线或曲线延伸并且具有窄的宽度。 开口形成在与线性末端边缘相邻的一侧或每侧上，或者形成在线状末端边缘的中间。 开口与由微针或微刀的底面形成的通道连通，以形成从微针或微刀的尖端到底部的通孔。 三角形通道具有（111）取向小面的六个侧壁。 微针或微刀用于透皮药物递送，体液抽出等。 还公开了生产微针或微刀的方法。

公开(公告)号：US20090011158A1

公开(公告)日：2009-01-08

申请号：US12050209

申请日：2008-03-18

Applicant: YEHOSHUA YESHURUN

Inventor： YEHOSHUA YESHURUN

IPC: B29D22/00 ,  H01L21/00

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0132 ,  B81C2201/0133 ,  Y10T428/13

Abstract: A method for forming a hollow microneedle structure includes processing the front side of a wafer to form at least one microneedle projecting from a substrate with a first part of a through-bore, formed by a dry etching process, passing through the microneedle and through a part of a thickness of the substrate. The backside of the wafer is also processed to form a second part of the through-bore by a wet etching process.

Abstract translation: 一种用于形成中空微针结构的方法包括处理晶片的前侧，以形成至少一个从基底突出的微针，该微针具有通过干蚀刻工艺形成的通孔的第一部分，穿过微针并通过 基板厚度的一部分。 晶片的背面也被处理以通过湿蚀刻工艺形成通孔的第二部分。

公开(公告)号：US20080299290A1

公开(公告)日：2008-12-04

申请号：US11660341

申请日：2005-08-16

Applicant: Andrew James Kirby

Inventor： Andrew James Kirby

IPC: A61M25/06

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C37/0053 ,  B29C64/135 ,  B29C2035/0827 ,  B29L2031/759 ,  B33Y80/00 ,  B81B2201/055

Abstract: A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles.

Abstract translation: 提供了制造微针的方法，该方法包括（i）将物质沉积到第一表面上，和（ii）从该物质形成固体针状形状。 该物质可以以非固体形式沉积并随后固化。 一种方法提供这种微针的阵列。

公开(公告)号：US20080097352A1

公开(公告)日：2008-04-24

申请号：US11520526

申请日：2006-09-12

Applicant: Patricia A. Beck ,  Ramesh Govinda Raju ,  Xio-An Sean Zhang

Inventor： Patricia A. Beck ,  Ramesh Govinda Raju ,  Xio-An Sean Zhang

IPC: A61M5/32

CPC classification number: B81C1/00111 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/685 ,  A61M37/0015 ,  B81B2201/055 ,  B81C2201/0197 ,  Y10T29/49204

Abstract: A method of fabricating a microneedle is disclosed. The method includes forming at least one recess in a substrate, the at least one recess comprising an apex, forming an electrically seed layer on the substrate including the at least one recess, forming at least one electrically nonconductive pattern on a portion of the seed layer, the at least one nonconductive pattern being a pattern for a sensory area, plating an electrically conductive material on the seed layer to create a plated layer with an opening that exposes a portion of the nonconductive pattern and separating the plated layer from the seed layer and the at least one nonconductive pattern to release a hollow microneedle comprising a tip and at least one sensory area.

Abstract translation: 公开了一种制造微针的方法。 该方法包括在衬底中形成至少一个凹部，所述至少一个凹部包括顶点，在衬底上形成包括所述至少一个凹部的电晶种层，在种子层的一部分上形成至少一个非导电图案 所述至少一个非导电图案是用于感觉区域的图案，在所述种子层上镀覆导电材料以产生具有暴露所述非导电图案的一部分并将所述镀层与所述种子层分离的开口的镀层，以及 所述至少一个非导电图案以释放包括尖端和至少一个感觉区域的中空微针。

公开(公告)号：US20070134829A1

公开(公告)日：2007-06-14

申请号：US11637020

申请日：2006-12-12

Applicant: Nicolle Wilke ,  Anthony Morrissey

Inventor： Nicolle Wilke ,  Anthony Morrissey

IPC: H01L21/00

CPC classification number: A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00626 ,  B81C99/0065 ,  B81C2201/0133 ,  B81C2201/0138

Abstract: A method of wet etching produces high-precision microneedle arrays for use in medical applications. The method achieves precise process control over microneedle fabrication, at single wafer or batch-level, using wet etching of silicon with potassium hydroxide (KOH) solution by accurately identifying the etch time endpoint. Hence, microneedles of an exactly required height, shape, sharpness and surface quality are achieved. The outcome is a reliable, reproducible, robust and relatively inexpensive microneedle fabrication process. Microneedles formed by KOH wet etching have extremely smooth surfaces and exhibit superior mechanical and structural robustness to their dry etched counterparts. These properties afford extra reliability to such silicon microneedles, making them ideal for medical applications. The needles can also be hollowed. Wet etched silicon microneedles can then be employed as masters to replicate the improved surface and structural properties in other materials (such as polymers) by moulding.

Abstract translation: 湿蚀刻的方法产生用于医疗应用的高精度微针阵列。 该方法通过精确地识别蚀刻时间终点，通过使用氢氧化钾（KOH）溶液对硅进行湿蚀刻，在单晶片或批次水平上实现了微针制造的精确过程控制。 因此，实现了精确要求的高度，形状，锐度和表面质量的微针。 结果是可靠，可重现，稳健且相对便宜的微针制作工艺。 通过KOH湿蚀刻形成的微针具有非常光滑的表面，并且对其干蚀刻的对应物表现出优异的机械和结构坚固性。 这些性能为这种硅微针提供了额外的可靠性，使其成为医疗应用的理想选择。 针也可以是中空的。 湿法蚀刻的硅微针可用作主机，通过模制复制其他材料（如聚合物）中改进的表面和结构性能。

公开(公告)号：US07132054B1

公开(公告)日：2006-11-07

申请号：US10936360

申请日：2004-09-08

Applicant: Stanley H. Kravitz ,  David Ingersoll ,  Carrie Schmidt ,  Jeb Flemming

Inventor： Stanley H. Kravitz ,  David Ingersoll ,  Carrie Schmidt ,  Jeb Flemming

IPC: C03C25/00 ,  C03C25/68 ,  B81C1/00

CPC classification number: C23F1/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  C03C15/00 ,  C03C23/002 ,  C03C23/007

Abstract: An inexpensive and rapid method for fabricating arrays of hollow microneedles uses a photoetchable glass. Furthermore, the glass hollow microneedle array can be used to form a negative mold for replicating microneedles in biocompatible polymers or metals. These microneedle arrays can be used to extract fluids from plants or animals. Glucose transport through these hollow microneedles arrays has been found to be orders of magnitude more rapid than natural diffusion.

Abstract translation: 用于制造中空微针阵列的廉价且快速的方法使用可光取代玻璃。 此外，玻璃中空微针阵列可用于形成用于在生物相容性聚合物或金属中复制微针的负模。 这些微针阵列可用于从植物或动物中提取液体。 已经发现通过这些中空微针阵列的葡萄糖传输比自然扩散更快的数量级。

公开(公告)号：US20060172541A1

公开(公告)日：2006-08-03

申请号：US11327463

申请日：2006-01-09

Applicant: Chang-seung Lee

Inventor： Chang-seung Lee

IPC: H01L21/302 ,  H01L21/311 ,  H01L21/461

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0115

Abstract: A method of fabricating a micro-needle array is provided. The method of fabricating a micro-needle array having a substrate having a first surface and a second surface spaced in a predetermined interval apart from the first surface, includes patterning on the first surface, thereby forming a shape of micro-needle bodies. Further, micro-passageways are formed that penetrate the first surface of the substrate from the second surface by a porous silicon process, and integrates the micro-passageways, thereby forming the bodies and channels of micro-needles.

Abstract translation: 提供一种制造微针阵列的方法。 制造具有第一表面和与第一表面隔开预定间隔的第二表面的基底的微针阵列的方法包括在第一表面上的图案化，从而形成微针体的形状。 此外，通过多孔硅工艺形成从第二表面穿透基板的第一表面的微通道，并且将微通道整合，从而形成微针的主体和通道。