公开(公告)号：US10609500B2

公开(公告)日：2020-03-31

申请号：US16292836

申请日：2019-03-05

Applicant: THE UNIVERSITY OF ROCHESTER

Inventor： Mark F. Bocko

IPC: H04S7/00 ,  H04R7/04 ,  H04R1/28 ,  H04R3/00 ,  H04R5/04

Abstract: A loudspeaker system composed of a flexible panel with an affixed array of force actuators, a signal processing system, and interface electronic circuits is described. The system described is capable of creating a pattern of standing bending waves at any location on the panel and the instantaneous amplitude, velocity, or acceleration of the standing waves can be controlled by an audio signal to create localized acoustic sources at the selected locations in the plane of the panel.

公开(公告)号：US20200054217A1

公开(公告)日：2020-02-20

申请号：US16346327

申请日：2017-11-03

Applicant: University of Rochester

Inventor： Kevin PARKER

IPC: A61B5/00

Abstract: A reverberant shear wave field in an object such as a patient's body or organ causes deformations in one or more selected directions measured with an imaging modality such as ultrasound or MR equipment or other imaging equipment, to estimate displacements in one or more selected directions over time increments and then viscoelastic properties such as stiffness or other parameters of the ROI.

公开(公告)号：US10544159B2

公开(公告)日：2020-01-28

申请号：US15492180

申请日：2017-04-20

Applicant: University of Rochester

Inventor： Rudi Fasan ,  Kai-Dong Zhang

IPC: C07D493/18 ,  C07D491/18 ,  C12N9/02 ,  C12P17/18

Abstract: Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.

公开(公告)号：US10450546B2

公开(公告)日：2019-10-22

申请号：US14764507

申请日：2014-02-06

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. Goldman ,  Su Wang

IPC: C12N5/071 ,  A01N63/00 ,  C12N5/079 ,  A61K9/00 ,  A61K35/30

Abstract: The present disclosure relates to a preparation of CD140a/PDGFRα positive cells that comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFRα. The preparation of cells is derived from pluripotent cells that were derived from skin cells, fibroblasts, umbilical cord blood, peripheral blood, bone marrow, or other somatic cells. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5+/PSA-NCAM−sorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of making, isolating and using the disclosed cell preparation are also described.

公开(公告)号：US20190319152A1

公开(公告)日：2019-10-17

申请号：US16456226

申请日：2019-06-28

Applicant: University of Rochester

Inventor： Chunlei Guo ,  Anatoliy Y. Vorobyev

IPC: H01L31/054 ,  B23K26/0622 ,  B23K26/352 ,  C22F3/00 ,  H01L31/0232 ,  B23K26/00 ,  B23K26/082

Abstract: A metal or metal alloy including a region with hierarchical micro-scale and nano-scale structure shapes, the surface region is super-hydrophobic and has a spectral reflectance of less than 30% for at least some wavelengths of electromagnetic radiation in the range of 0.1 μm to 10 μm. Methods for forming the hierarchical micro-scale and nano-scale structure shapes on the metal or metal alloy are also described.

公开(公告)号：US20190290695A1

公开(公告)日：2019-09-26

申请号：US16302734

申请日：2017-05-19

Applicant: University of Rochester

Inventor： Richard Waugh ,  Julia M. Kuebel ,  Yingye Fang ,  Greg Palis

IPC: A61K35/18 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42 ,  C12M1/26

Abstract: The present disclosure relates to devices for producing mature red blood cells and methods for using the same. The devices comprise micro-slit filters that mechanically stimulate cells in custom cell medium to impart the cells with physical characteristics that enable the cells to pass through and survive human vasculature.

公开(公告)号：US20190249143A1

公开(公告)日：2019-08-15

申请号：US16395625

申请日：2019-04-26

Applicant: University of Rochester

Inventor： James Palis ,  Samantha England ,  Ah Ram Kim

IPC: C12N5/078 ,  A61K35/18

CPC classification number: C12N5/0641 ,  A61K35/18 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2506/02 ,  C12N2510/00

Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.

公开(公告)号：US10376535B2

公开(公告)日：2019-08-13

申请号：US15561466

申请日：2016-03-28

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Richard G. Moore ,  Rakesh K. Singh ,  Naohiro Yano

IPC: A61K48/00 ,  C07H21/02 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/5025 ,  A61K31/58 ,  A61K31/713 ,  A61P35/00 ,  A61K33/24 ,  A61K45/00 ,  G01N33/574

Abstract: Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

公开(公告)号：US20190200152A1

公开(公告)日：2019-06-27

申请号：US16292836

申请日：2019-03-05

Applicant: THE UNIVERSITY OF ROCHESTER

Inventor： Mark F. Bocko

IPC: H04S7/00 ,  H04R7/04 ,  H04R3/00 ,  H04R5/04 ,  H04R1/28

CPC classification number: H04S7/30 ,  H04R1/2811 ,  H04R3/00 ,  H04R5/04 ,  H04R7/045 ,  H04R2440/01 ,  H04R2440/05 ,  H04R2440/07 ,  H04R2499/15

Abstract: A loudspeaker system composed of a flexible panel with an affixed array of force actuators, a signal processing system, and interface electronic circuits is described. The system described is capable of creating a pattern of standing bending waves at any location on the panel and the instantaneous amplitude, velocity, or acceleration of the standing waves can be controlled by an audio signal to create localized acoustic sources at the selected locations in the plane of the panel.

公开(公告)号：US20190175550A1

公开(公告)日：2019-06-13

申请号：US16325752

申请日：2017-08-16

Applicant: University of Rochester

Inventor： Paul M. Dunman ,  Rachel Wozniak

IPC: A61K31/395 ,  A61K31/505 ,  A61K31/496 ,  A61P31/04 ,  A61P27/02 ,  A61P27/06 ,  A61P27/12

Abstract: The present invention features an antibacterial composition comprising 1) a composition A comprising polymyxin B and trimethoprim; and 2) an antibiotic agent selected from the group consisting of rifampicin, rifabutin, rifapentine, rifaximin, pefloxacin mesylate, sparfloxacin, sarafloxacin HCl, tobramycin, lomefloxacin, besifloxacin, danofloxacin mesylate, enrofloxacin, nadifloxacin and clinafloxacin, a topical pharmaceutical thereof, and a method of treating bacterial infections using mixtures of 1 and 2.