公开(公告)号：US20110003999A1

公开(公告)日：2011-01-06

申请号：US12919362

申请日：2009-02-17

Applicant: Michael DOCKNER

Inventor： Michael DOCKNER

IPC: C07D213/56 ,  C07D231/10

CPC classification number: G01B11/2441 ,  G01B9/0201 ,  G01B9/02057 ,  G01B9/0209 ,  G01B2290/70 ,  G01N21/95 ,  G01N2021/9513

Abstract: The present invention relates to a process for preparing substituted biphenylanilides of the formula I which comprises reacting a compound of formula II in the presence of a base and of a palladium catalyst selected from the group of: a) palladium-triarylpliosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid according to formula (III)

Abstract translation: 本发明涉及一种制备式I取代的联苯酰苯胺的方法，其包括在碱存在下与式Ⅱ化合物与钯催化剂反应，所述钯催化剂选自：a）钯 - 三芳基叉膦或三烷基膦配合物与 b）在三芳基膦或三烷基膦作为络合配体的存在下钯的盐，或c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与二苯基硼酸 根据式（III）

公开(公告)号：US07821647B2

公开(公告)日：2010-10-26

申请号：US12070844

申请日：2008-02-21

Applicant: Philip Robert LeBlanc ,  Vitor Marino Schneider ,  James Patrick Trice

Inventor： Philip Robert LeBlanc ,  Vitor Marino Schneider ,  James Patrick Trice

IPC: G01B11/02

CPC classification number: G01B11/2441 ,  G01B9/0201 ,  G01B9/02057 ,  G01B9/0209 ,  G01B2290/70 ,  G01N21/95 ,  G01N2021/9513

Abstract: An apparatus for measuring surface topography of an object includes an optical arrangement capable of directing a first light beam at a surface of the object, providing a second light beam coherent with and spatially phase-shifted relative to the first light beam, and generating an interference beam from the second light beam and a reflection of the first light beam from the surface of the object. The apparatus further includes at least one line scan sensor for detecting and measuring the interference beam.

Abstract translation: 一种用于测量物体的表面形貌的装置包括能够将第一光束引导到物体表面的光学装置，提供与第一光束相干并在空间上相对于第一光束的第二光束，并产生干涉 来自第二光束的光束和来自物体表面的第一光束的反射。 该装置还包括用于检测和测量干涉光束的至少一个线扫描传感器。

公开(公告)号：US07797119B2

公开(公告)日：2010-09-14

申请号：US11956129

申请日：2007-12-13

Applicant: Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

Inventor： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

IPC: G01R35/00

CPC classification number: G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

Abstract: Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

Abstract translation: 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

公开(公告)号：US07697145B2

公开(公告)日：2010-04-13

申请号：US10854426

申请日：2004-05-27

Applicant: Joseph A. Izatt

Inventor： Joseph A. Izatt

IPC: G01B9/02

CPC classification number: G01B9/02007 ,  G01B9/02004 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02079 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/40 ,  G01B2290/45 ,  G01B2290/70

Abstract: Optical coherence tomography (OCT) is an imaging method which can image with micrometer-scale resolution up to a few millimeters deep into, for example, living biological tissues and preserved tissue samples. An improved apparatus and image reconstruction algorithm for parallel Fourier Domain OCT which greatly eases requirements for interferometer stability and also allows for more efficient parallel image acquisition is provided. The apparatuses and algorithms reconstruct images from interfered, low-coherence, multiwave length signals having a π radian phase difference relative to one another. Other numbers of signals and other phase differences may be alternatively used, with some combinations resulting in higher resolution and image stability. The apparatus also eliminates a need for bulk optics to modulate a phase delay in a reference arm of the optical path. Images may be reconstructed using two spectrometers, where each is coupled to a detector array such as a photodiode array.

Abstract translation: 光学相干断层扫描（OCT）是一种成像方法，可以将尺寸分辨率高达几毫米的微米尺度分辨率成像到例如活的生物组织和保留的组织样本中。 提供了一种用于并行傅里叶域OCT的改进的装置和图像重建算法，其大大减轻了干涉仪稳定性的要求，并且还提供了更有效的并行图像采集。 这些装置和算法从具有＆pgr的干扰，低相干，多波长信号重构图像。 弧度相位差相对于彼此。 可以替代地使用其他数量的信号和其它相位差，其中一些组合导致更高的分辨率和图像稳定性。 该装置还消除了对光学路径的参考臂中的相位延迟调制体光学器件的需要。 可以使用两个光谱仪重建图像，其中每个光谱仪耦合到诸如光电二极管阵列的检测器阵列。

公开(公告)号：US07630083B2

公开(公告)日：2009-12-08

申请号：US11955834

申请日：2007-12-13

Applicant: Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

Inventor： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

IPC: G01B11/02 ,  G01B9/02

CPC classification number: G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

Abstract: Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

Abstract translation: 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

公开(公告)号：US07535577B2

公开(公告)日：2009-05-19

申请号：US11828764

申请日：2007-07-26

Applicant: Adrian Gh. Podoleanu ,  David A. Jackson ,  John A. Rogers ,  George M. Dobre ,  Radu G. Cucu

Inventor： Adrian Gh. Podoleanu ,  David A. Jackson ,  John A. Rogers ,  George M. Dobre ,  Radu G. Cucu

IPC: G01B9/02 ,  G01B11/02

CPC classification number: A61B3/102 ,  A61B5/0066 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/4795

Abstract: OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

Abstract translation: OCT设备包括具有输入分束器和50/50输出分离器的干涉仪。 输入分路器的分频比可以根据光源的功率和平衡接收机的不匹配进行优化。 输入分路器是平板分光器，以最小化干涉仪中的杂散反射光，并允许在OCT或共聚焦状态下对装置的顺序操作。 两种方案之间的切换可以是随意的，或者与进行准同时OCT /共聚焦成像或替代帧，共聚焦和OCT的en-face扫描同步。 通过使用极化敏感元件，在每个方案中提供了两个通道，OCT和共聚焦。 两个共焦极化敏感通道可以允许在OCT测量或OCT成像之前调整补偿器。

公开(公告)号：US07508523B2

公开(公告)日：2009-03-24

申请号：US11779962

申请日：2007-07-19

Applicant: Shoude Chang ,  Costel P. Flueraru ,  Sherif S. Sherif

Inventor： Shoude Chang ,  Costel P. Flueraru ,  Sherif S. Sherif

IPC: G01B9/02

CPC classification number: G01N21/4795 ,  G01B9/0201 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45

Abstract: The invention provides an interferometric system and method for quadrature detection of optical characteristics of a sample. The system includes a Mach-Zehnder interferometer providing a variable optical delay between light collected from the sample and reference light. The Mach-Zehnder interferometer has an output M×N coupler with N≧3 output ports. Two differential detectors, each having two input ports coupled to a different two of the N output ports of the M×N coupler, produce first and second electrical signals having an interferometric phase shift. A processor is provided for computing real and imaginary parts of a complex refractive index of the sample from the first and second electrical signals by using complex deconvolution.

Abstract translation: 本发明提供一种用于正交检测样品的光学特性的干涉系统和方法。 该系统包括马赫 - 曾德尔干涉仪，其在从样品收集的光和参考光之间提供可变的光学延迟。 Mach-Zehnder干涉仪具有输出MxN耦合器，N> 3个输出端口。 两个差分检测器各自具有耦合到MxN耦合器的N个输出端口中的不同两个的两个输入端口产生具有干涉相移的第一和第二电信号。 提供了一种处理器，用于通过使用复数去卷积来从第一和第二电信号计算样本的复折射率的实部和虚部。

公开(公告)号：US07474407B2

公开(公告)日：2009-01-06

申请号：US10546421

申请日：2004-02-17

Applicant: Mikhail Gutin

Inventor： Mikhail Gutin

IPC: G01B9/02

CPC classification number: G01B9/02007 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/411 ,  A61B5/7203 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02012 ,  G01B9/02027 ,  G01B9/02034 ,  G01B9/02091 ,  G01B2290/65 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2021/458 ,  G01N2021/4709 ,  G01N2021/4742 ,  G01N2201/0691 ,  G01N2201/08

Abstract: Optical coherence tomography with 3D coherence scanning is disclosed, using at least three fibers (201, 202, 203) for object illumination and collection of backscattered light. Fiber tips (1, 2, 3) are located in a fiber tip plane (71) normal to the optical axis (72). Light beams emerging from the fibers overlap at an object (122) plane, a subset of intersections of the beams with the plane defining field of view (266) of the optical coherence tomography apparatus. Interference of light emitted and collected by the fibers creates a 3D fringe pattern. The 3D fringe pattern is scanned dynamically over the object by phase shift delays (102, 104) controlled remotely, near ends of the fibers opposite the tips of the fibers, and combined with light modulation. The dynamic fringe pattern is backscattered by the object, transmitted to a light processing system (108) such as a photo detector, and produces an AC signal on the output of the light processing system (108). Phase demodulation of the AC signal at selected frequencies and signal processing produce a measurement of a 3D profile of the object.

Abstract translation: 公开了具有3D相干扫描的光学相干断层摄影，使用至少三个光纤（201,202,203）进行物体照明和收集后向散射光。 纤维尖端（1,2,3）位于垂直于光轴（72）的纤维末端平面（71）中。 从光纤出射的光束在对象（122）平面处重叠，光束与定义光学相干断层摄影装置的视场（266）的平面的交点的子集重叠。 由纤维发出和收集的光的干涉产生3D条纹图案。 通过远程控制的相移延迟（102,104）在物体上动态扫描3D条纹图案，纤维的近端与光纤的尖端相反，并与光调制组合。 动态条纹图案被物体反向散射，传输到诸如光电检测器的光处理系统（108），并在光处理系统（108）的输出上产生AC信号。 所选频率的AC信号的相位解调和信号处理产生对象的3D轮廓的测量。

公开(公告)号：US07359062B2

公开(公告)日：2008-04-15

申请号：US11009717

申请日：2004-12-09

Applicant: Zhongping Chen ,  Jun Zhang ,  J. Stuart Nelson

Inventor： Zhongping Chen ,  Jun Zhang ,  J. Stuart Nelson

IPC: G01B9/02

CPC classification number: A61B5/0066 ,  A61B5/0261 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726 ,  G01B9/02004 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: A system for tomographic imaging includes a source of at least partially coherent radiation, a frequency-swept laser source and an interferometer. The radiation in the interferometer is phase modulated at a modulation frequency for elimination of DC and autocorrelation noises as well as the mirror image. The interference fringes of the radiation backscattered from the sample into the interferometer are detected to obtain a spectral signal. The spectral signal of the detected backscattered interference fringes is transformed to obtain a location dependent signal at each pixel location in a data window. A tomographic image of the fluid flow in the data window is generated for display and of the structure of the scanned fluid flow sample in the data window from the location dependent signal is generated.

Abstract translation: 用于断层成像的系统包括至少部分相干辐射源，频率扫描激光源和干涉仪。 干涉仪中的辐射以调制频率进行相位调制，以消除DC和自相关噪声以及镜像。 检测从样品反向散射到干涉仪中的辐射的干涉条纹以获得光谱信号。 所检测的反向散射干涉条纹的光谱信号被变换以在数据窗口中的每个像素位置处获得与位置相关的信号。 生成数据窗口中的流体流的断层图像，用于显示数据窗口中扫描的流体流动样本的结构，并且从位置相关信号生成。

公开(公告)号：US20080024763A1

公开(公告)日：2008-01-31

申请号：US11768265

申请日：2007-06-26

Applicant: Chian Chiu Li

Inventor： Chian Chiu Li

IPC: G01N21/00

CPC classification number: G01N21/45 ,  G01B9/0201 ,  G01B9/02049 ,  G01B2290/35 ,  G01B2290/45 ,  G01J3/4532

Abstract: Disclosed are compact optical interferometer array, miniature optical interferometer array, and miniature optical interferometer. The interferometer arrays contain a spatial phase modulator array and a detector array. They are used for conducting multiple measurements. The miniature interferometer has only one component—a spatial phase modulator. Without passing through any focus lens, beam portions coming out of the modulator spread and merge together by themselves. Size of the miniature interferometer can reach subwavelength or even nanoscale. The interferometer array and miniature interferometer find applications in miniature spectrometer, color filter, display, adjustable subwavelength grating, etc.

Abstract translation: 公开了紧凑型光学干涉仪阵列，微型光学干涉仪阵列和微型光学干涉仪。 干涉仪阵列包含空间相位调制器阵列和检测器阵列。 它们用于进行多个测量。 微型干涉仪只有一个组件 - 空间相位调制器。 不通过任何聚焦透镜，从调制器出来的光束部分自身扩散并合并在一起。 微型干涉仪的尺寸可达到亚波长甚至纳米级。 干涉仪阵列和微型干涉仪可用于微型光谱仪，滤色片，显示屏，可调式亚波长光栅等。