公开(公告)号：US20160003823A1

公开(公告)日：2016-01-07

申请号：US14829572

申请日：2015-08-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes

IPC: G01N33/569

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20150368717A1

公开(公告)日：2015-12-24

申请号：US14789930

申请日：2015-07-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Surekha Gangakhedkar ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Paul Patel ,  Joy Roy ,  Timothy Smith ,  Daniel Young ,  Ian Gibbons

IPC: C12Q1/68 ,  B01L7/00 ,  C12Q1/70

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20150362431A1

公开(公告)日：2015-12-17

申请号：US14761048

申请日：2014-01-16

Applicant: MAST GROUP LIMITED

Inventor： Ken JIN WONG ,  David Hugh WILLIAMS ,  Iain MCELARNEY ,  Elizabeth GILLIES

IPC: G01N21/64 ,  G01N35/04 ,  G01N33/487 ,  G01N35/00

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/545 ,  B01L2300/021 ,  B01L2300/0803 ,  G01J3/46 ,  G01J5/605 ,  G01J2003/466 ,  G01N33/487 ,  G01N35/00 ,  G01N35/00871 ,  G01N35/04 ,  G01N2021/6439 ,  G01N2035/00158 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0441 ,  G01N2201/024 ,  G01N2201/0256 ,  G01N2201/0407

Abstract: A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.

Abstract translation: 用于进行测定的系统包括电源（16），用于控制测定的控制器（13）和可操作地彼此连接的多个测定单元（14），使得控制器可以与测定单元和系统 能够进行测定。 测定装置包括具有流体连接的多个腔室的基本上圆形的本体（24），使得流体可以在所述室之间通过，并且具有设置在其中的用于接收样品的样品入口（202）的中心毂（200）。

公开(公告)号：US20150338428A1

公开(公告)日：2015-11-26

申请号：US14789920

申请日：2015-07-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Surekha Gangakhedkar ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Paul Patel ,  Joy Roy ,  Timothy Smith ,  Daniel Young ,  Ian Gibbons

IPC: G01N35/02 ,  G01N35/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract translation: 提供系统和方法用于样品处理。 可以提供能够接收样品并执行样品制备，样品测定和检测步骤中的一种或多种的装置。 该装置可能能够进行多个测定。 该装置可以包括一个或多个可以执行样品制备，样品测定和检测步骤中的一个或多个的模块。 该装置可以能够使用小体积的样品来执行步骤。

公开(公告)号：US08881580B2

公开(公告)日：2014-11-11

申请号：US13392098

申请日：2010-07-28

Applicant: Ulrich Lundgreen ,  Aria Farjam

Inventor： Ulrich Lundgreen ,  Aria Farjam

IPC: G01N33/00 ,  G01N21/11 ,  F04B43/12 ,  B01L3/00 ,  G01N35/10 ,  G01N21/85 ,  F04B43/08 ,  G01N21/84 ,  G01N21/03 ,  G01N33/18 ,  G01N21/78 ,  G01N21/05 ,  G01N1/40

CPC classification number: G01N21/8507 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2400/0481 ,  F04B43/082 ,  F04B43/12 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/18 ,  G01N35/1095 ,  G01N2001/4016 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/054 ,  G01N2021/8411 ,  G01N2201/0218 ,  G01N2201/024

Abstract: A process analysis unit includes a base module and an exchangeable cartridge module. The base module comprises at least one independent pump drive, and an analyte sensor without a fluidic measuring section. The cartridge module comprises a liquid reservoir tank, a sample taking device, at least one drive-less pump mechanism configured as a peristaltic membrane pump, a fluidic measuring section for the analyte sensor, and a plastic material plate with groove-like microfluidic channels configured to connect the liquid reservoir tank, the at least one drive-less pump mechanism, and a measuring section. The drive-less pump mechanism is driven pneumatically and pumps a liquid from the liquid reservoir tank. When the cartridge module is connected to the base module, the at least one drive-less pump mechanism is connected to and is driven by the at least one independent pump drive, and the fluidic measuring section is connected to the analyte sensor.

Abstract translation: 过程分析单元包括基本模块和可更换盒式模块。 基本模块包括至少一个独立的泵驱动器和不具有流体测量部分的分析物传感器。 盒式模块包括液体储存罐，取样装置，配置为蠕动膜泵的至少一个无驱动泵机构，用于分析物传感器的流体测量部分，以及配置有凹槽状微流体通道的塑料材料板 连接储液箱，至少一个无驱动泵机构和测量部。 无驱动泵机构被气动地驱动，并从液体储存罐泵送液体。 当墨盒模块连接到基座模块时，至少一个无驱动泵机构连接到并由至少一个独立泵驱动器驱动，并且流体测量部分连接到分析物传感器。

公开(公告)号：US20140118745A1

公开(公告)日：2014-05-01

申请号：US14125093

申请日：2012-06-25

Applicant: Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

Inventor： Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

IPC: G01N21/59

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1′) is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2′) are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2′) are detected by a single image sensor (155).

Abstract translation: 本发明涉及一种用于检查样品的装置，其中第一输入光束（L1）在样品室（111）的检测表面处被全内反射，而第二输入光束（L1'）被透射 样品室（111）。 检测所得到的第一和第二输出光束（L2，L2'），并且可以分别对沮丧的全内反射和光吸收率进行评估。 优选地，两个输出光束（L2，L2'）由单个图像传感器（155）检测。

公开(公告)号：US20120234393A1

公开(公告)日：2012-09-20

申请号：US13457199

申请日：2012-04-26

Applicant: George Maltezos ,  Jeremy Witzens ,  Axel Scherer

Inventor： George Maltezos ,  Jeremy Witzens ,  Axel Scherer

IPC: F03B11/00

CPC classification number: G01N21/6428 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  B81C1/00119 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6456 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2201/024 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/1714 ,  Y10T137/2202 ,  Y10T137/8811

Abstract: An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Abstract translation: 用于分析样品，特别是生物样品的装置。 该装置包含具有管芯的微流体芯片，适于通过生物样品中目标分子的存在而被选择性地活化或失活。 该装置还包含用于发射微流芯片照明的光源和滤光器，以允许通过靶分子的存在激活或去激活来自模具的光的通过。 还公开了一种用于对微流体芯片加压的方法，其中设置有腔室，腔室与微流体芯片连接，并且将压力施加到腔室。

公开(公告)号：US20120077282A1

公开(公告)日：2012-03-29

申请号：US13311164

申请日：2011-12-05

Applicant: Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

Inventor： Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

IPC: G01N21/75

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support of the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges may be a luminescence cartridge that includes an integrated detector that is movable toward and away from a sample carrier of the apparatus, and thus toward and away from a sample located at the sample carrier.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 墨盒以“插入”格式与装置的墨盒支架可拆卸地接合，使得一个墨盒可以从设备中取出，另一墨盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个盒可以是发光盒，其包括集成检测器，该检测器可朝向和远离装置的样品载体移动，并且因此朝向和离开位于样品载体处的样品。

公开(公告)号：US20110304844A1

公开(公告)日：2011-12-15

申请号：US12861942

申请日：2010-08-24

Applicant: Bert WILLING ,  Markus Kohli ,  Andreas Seifert

Inventor： Bert WILLING ,  Markus Kohli ,  Andreas Seifert

IPC: G01N21/61 ,  G01J3/00

CPC classification number: G01N21/39 ,  G01N21/0332 ,  G01N33/004 ,  G01N33/006 ,  G01N2021/158 ,  G01N2021/3129 ,  G01N2021/3144 ,  G01N2021/354 ,  G01N2021/399 ,  G01N2201/024 ,  Y02A50/244

Abstract: An TDLS gas sensor with a measuring pick-up to be arranged outside of the interior chamber of an incubator or a climate chamber of similar design, and with an absorption pick-up to be arranged inside the interior chamber, and also with a window separating the measuring area and absorption area for the atmospheric separation of the laser diode from the interior chamber of the incubator, with the window being arranged at an angle to the axis of the laser beam emitted by a laser diode, and with the optronic components being arranged in a block of material in the measuring pick-up, said block being made of thermally well-conducting material and serving as heat sink, and with a heating system for the window in the measuring pick-up. The TDLS gas sensor is easy to install and remove and permits the measurement of moisture and of the carbon dioxide concentration in one measuring cycle. However, it does not need to be removed for the sterilization. By installing an additional laser diode for measuring oxygen, the TDLS gas sensor can be used to perform a wide bandwidth of measurements. In addition, the invention concerns a process for measuring the moisture and the carbon dioxide concentration.

Abstract translation: 具有测量拾取器的TDLS气体传感器将布置在孵化器或类似设计的气候室的内部室外，并且吸收拾取器布置在内部室内，并且还具有分隔开的窗口 所述测量区域和所述激光二极管与所述培养箱的内部室大气分离的吸收区域，其中所述窗口以与激光二极管发射的激光束的轴线成一定角度布置，并且所述光电子部件被布置 在测量拾取器中的一块材料中，所述块由导热材料制成并用作散热器，并且具有用于测量拾取器中的窗口的加热系统。 TDLS气体传感器易于安装和拆卸，允许在一个测量周期内测量水分和二氧化碳浓度。 但是，不需要去除灭菌。 通过安装用于测量氧气的附加激光二极管，TDLS气体传感器可用于执行宽带宽的测量。 此外，本发明涉及一种测量水分和二氧化碳浓度的方法。

公开(公告)号：US20110299289A1

公开(公告)日：2011-12-08

申请号：US12795501

申请日：2010-06-07

Applicant: William H. Wynn

Inventor： William H. Wynn

IPC: F21V19/00

CPC classification number: G01N21/01 ,  G01N21/31 ,  G01N2201/024

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract translation: 自对准光源和检测器组件，其具有安装在预定的固定位置的传感器支撑件，相对于传感器支撑件安装在预定的固定位置的光源保持器，安装在传感器支架上的固定位置的传感器，以及 灯组件，其可拆卸地安装到光源保持器上，该预定位置由彼此接合的配合表面限定，并且每当灯组件安装在保持器中时将灯组件安置在预定位置。