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公开(公告)号：US09696258B2
公开(公告)日：2017-07-04
申请号：US15261724
申请日：2016-09-09
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Keith G. Fife , David Boisvert
IPC: H01L27/00 , G01N21/64 , H01L27/146 , H01L27/148 , C12Q1/68 , G01S7/486
CPC classification number: G01N21/6428 , C12Q1/6869 , G01N21/6408 , G01N21/645 , G01N21/6458 , G01N2021/6439 , G01N2021/6441 , G01N2201/06113 , G01N2201/0697 , G01S7/4863 , G01S7/4865 , H01L27/14603 , H01L27/14687 , H01L27/14812
Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
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公开(公告)号：US20170184504A1
公开(公告)日：2017-06-29
申请号：US15313420
申请日：2015-08-13
Applicant: Canon Kabushiki Kaisha
Inventor： Naoki KOHARA
CPC classification number: G01N21/65 , G01J3/10 , G01N2021/655 , G01N2201/06113 , G01N2201/0697 , G01N2201/105 , G02B21/0032 , G02B21/0076 , G02F1/3534 , H01S3/13 , H01S3/2391
Abstract: A pulsed light synchronizer synchronizes a first pulsed light having a first period and a second pulsed light and having a second period equal to the first period with each other. A third pulsed light is acquired by providing a first delay time between two pulsed lights acquired by dividing the first pulsed light, and by multiplexing the pulsed lights acquired from the first pulsed light. A fourth pulsed light is acquired by providing a second delay time between two pulsed lights acquired by dividing the second pulsed light, and by multiplexing the pulsed lights acquired from the second pulsed light. The pulsed light synchronizer detects, through a detector, a pulsed light acquired by multiplexing the third and fourth pulsed lights, and adjusts at least one of the first and second periods based on a timing difference between the third and fourth pulsed lights acquired from the detector.
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公开(公告)号：US09682376B2
公开(公告)日：2017-06-20
申请号：US14266894
申请日：2014-05-01
Applicant: OPKO Diagnostics, LLC
Inventor： Vincent Linder , David Steinmiller , Jason Taylor
IPC: B01L3/00 , G01N21/59 , G01N33/543 , G01N33/574 , B01L7/00
CPC classification number: B01L3/502746 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0673 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2200/147 , B01L2300/021 , B01L2300/023 , B01L2300/027 , B01L2300/04 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/12 , B01L2300/14 , B01L2300/16 , B01L2300/168 , B01L2300/1827 , B01L2300/1894 , B01L2400/0475 , B01L2400/049 , B01L2400/0666 , B01L2400/082 , G01N21/05 , G01N21/59 , G01N21/64 , G01N21/76 , G01N33/54313 , G01N33/54366 , G01N33/57434 , G01N2201/02 , G01N2201/0612 , G01N2201/062 , G01N2201/0621 , G01N2201/0697 , G01N2333/96433 , Y10T137/0324 , Y10T436/12
Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.
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公开(公告)号：US20170167974A1
公开(公告)日：2017-06-15
申请号：US15039364
申请日：2014-11-12
Applicant: CANON KABUSHIKI KAISHA
Inventor： Takayuki Koizumi
IPC: G01N21/3586 , G01N21/95
CPC classification number: G01N21/3586 , G01N21/9508 , G01N2201/06113 , G01N2201/0697
Abstract: The present invention relates to an information obtaining apparatus that obtains information of a sample, the information obtaining apparatus including an irradiation unit configured to irradiate the sample with a terahertz wave, a detection unit configured to detect the terahertz wave reflected by the sample, a spectrum obtaining unit configured to obtain a spectrum from a temporal waveform obtained by using a detection result of the detection unit, an angle information obtaining unit configured to obtain information related to an incident angle of the terahertz wave from the irradiation unit with respect to the sample by using the spectrum, and a control unit configured to adjust the incident angle by referring to the information related to the incident angle.
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公开(公告)号：US20170135582A1
公开(公告)日：2017-05-18
申请号：US15353198
申请日：2016-11-16
Inventor： Seongho Cho , Gajendra Singh , Juneyoung Lee
CPC classification number: A61B5/0075 , A61B5/725 , G01J3/0232 , G01J3/027 , G01J3/10 , G01J3/14 , G01J3/18 , G01J3/2803 , G01J3/36 , G01J3/44 , G01J2003/1217 , G01J2003/1234 , G01J2003/2806 , G01J2003/4424 , G01N21/65 , G01N2201/06113 , G01N2201/068 , G01N2201/0697 , G01N2201/12
Abstract: Provided are a Raman signal measuring method and apparatus which use a difference in a time scale between Raman scattered light and fluorescence. Thus, after exciting light is incident upon a target object, light scattered from the target object may be detected before the target object generates fluorescence in response to the exciting light. As a result, a Raman signal in which background fluorescence is reduced may be obtained.
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Patent Agency Ranking
公开(公告)号：US20170102338A1
公开(公告)日：2017-04-13
申请号：US15299662
申请日：2016-10-21
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Yukihiro SHIBATA , Kei SHIMURA , Sachio UTO , Toshifumi HONDA
IPC: G01N21/88 , G01N21/95 , G01N21/958 , G01N21/956 , G01N21/94
CPC classification number: G01N21/8806 , G01N21/8851 , G01N21/94 , G01N21/9501 , G01N21/956 , G01N21/958 , G01N2021/8822 , G01N2021/8848 , G01N2201/06113 , G01N2201/068 , G01N2201/0697 , G01N2201/12 , G03F7/7065
Abstract: To increase the illumination efficiency by facilitating the change of the incident angle of illumination light with a narrow illumination width according to an inspection object and enabling an illumination region to be effectively irradiated with light, provided is a defect inspection method for obliquely irradiating a sample mounted on a table that is moving continuously in one direction with illumination light, collecting scattered light from the sample obliquely irradiated with the illumination light, detecting an image of the surface of the sample formed by the scattered light, processing a signal obtained by detecting the image formed by the scattered light, and extracting a defect candidate, wherein the oblique irradiation of the light is implemented by linearly collecting light emitted from a light source, and obliquely projecting the collected light onto the surface of the sample, thereby illuminating a linear region on the surface of the sample.
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公开(公告)号：US20160377543A1
公开(公告)日：2016-12-29
申请号：US15261697
申请日：2016-09-09
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Keith G. Fife , David Boisvert
CPC classification number: G01N21/6428 , C12Q1/6869 , G01N21/6408 , G01N21/645 , G01N21/6458 , G01N2021/6439 , G01N2021/6441 , G01N2201/06113 , G01N2201/0697 , G01S7/4863 , G01S7/4865 , H01L27/14603 , H01L27/14687 , H01L27/14812
Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
Abstract translation: 集成电路包括被配置为接收入射光子的光电检测区域。 光检测区域被配置为响应于入射光子而产生多个电荷载流子。 集成电路还包括至少一个电荷载体存储区域。 集成电路还包括电荷载流子分离结构，其被配置为基于产生电荷载流子的时间来选择性地将多个电荷载流子的载流子引导到至少一个电荷载流子存储区域中。
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公开(公告)号：US20160349179A1
公开(公告)日：2016-12-01
申请号：US15232091
申请日：2016-08-09
Inventor： Daniel Rochette , Pascal Gallant , Ozge Mermut , Francois Baribeau , Isabelle Noiseux , Isabelle Gosselin
CPC classification number: G01N21/6428 , A61L2/28 , A61L2202/24 , G01N21/6486 , G01N21/94 , G01N2021/6417 , G01N2021/6439 , G01N2201/06113 , G01N2201/068 , G01N2201/0697 , G01N2201/10 , G01N2201/105
Abstract: A method for optical detection of residual soil on articles (such as medical instruments and equipment), after completion of a washing or a rinsing operation by a washer. A soil detection system provides an indication of soil on the articles by detecting luminescent radiation emanating from the soil in the presence of ambient light.
Abstract translation: 在清洗完成洗涤或漂洗操作之后，用光学检测物品（例如医疗仪器和设备）上的残留土壤的方法。 土壤检测系统通过在环境光的存在下检测从土壤发出的发光辐射来提供物品上的土壤的指示。
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89.发明申请公开(公告)号：US20160285223A1
公开(公告)日：2016-09-29
申请号：US15176346
申请日：2016-06-08
Applicant: KLA-Tencor Corporation
Inventor： Yung-Ho Chuang , J. Joseph Armstrong , Justin Dianhuan Liou , Vladimir Dribinski , David L. Brown
CPC classification number: H01S3/0057 , G01N21/21 , G01N21/9501 , G01N2201/06113 , G01N2201/0683 , G01N2201/0697 , G02B5/0816 , G02B5/3083 , G02B27/281 , G02B27/283 , G02B27/286 , H01S3/083
Abstract: A pulse multiplier includes a polarizing beam splitter, a wave plate, and a set of multi-surface reflecting components (e.g., one or more etalons and one or more mirrors). The polarizing beam splitter passes input laser pulses through the wave plate to the multi-surface reflecting components, which reflect portions of each input laser pulse back through the wave plate to the polarizing beam splitter. The polarizing beam splitter reflects each reflected portion to form an output of the pulse multiplier. The multi-surface reflecting components are configured such that the output pulses exiting the pulse multiplier have an output repetition pulse frequency rate that is at least double the input repetition pulse frequency.
Abstract translation: 脉冲倍增器包括偏振分束器，波片和一组多表面反射分量（例如，一个或多个标准具和一个或多个反射镜）。 偏振分束器将输入的激光脉冲通过波片传递到多表面反射分量，其将每个输入激光脉冲的部分反射通过波片到偏振分束器。 偏振分束器反射每个反射部分以形成脉冲乘法器的输出。 多表面反射部件被配置为使得离开脉冲乘法器的输出脉冲的输出重复脉冲频率至少是输入重复脉冲频率的两倍。
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公开(公告)号：US20160266041A1
公开(公告)日：2016-09-15
申请号：US14929885
申请日：2015-11-02
Applicant: Singulex, Inc.
Inventor： Richard Livingston
CPC classification number: G01N21/6428 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , G01N15/14 , G01N15/1429 , G01N15/1434 , G01N15/1456 , G01N15/1463 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/6458 , G01N33/53 , G01N2015/0038 , G01N2015/1402 , G01N2015/1447 , G01N2015/1452 , G01N2201/02 , G01N2201/06113 , G01N2201/062 , G01N2201/0697
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
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