公开(公告)号：US20040013569A1

公开(公告)日：2004-01-22

申请号：US10079635

申请日：2002-02-19

Inventor： Kenneth J. Balkus JR. ,  Paul Pantano ,  Claudia C. Meek ,  Decio H. Coutinho

IPC: G01N021/76

CPC classification number: G01N21/6452 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/00502 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00702 ,  B01J2219/0072 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0846

Abstract: A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into wells etched in an optical fiber bundle. The chemical functionalities are encoded on separate shaped molecular sieve particles using luminescent dyes and/or molecular sieve particle shapes and thus, a single sensor array may carry thousands of chemistries. Such encoded molecular sieve particles can provide at least a five-fold enhancement in tunable parameters for increasing the encoding possibilities of high throughput screening assays relative to the present dye-modified polymeric microsphere standard.

公开(公告)号：US5673341A

公开(公告)日：1997-09-30

申请号：US584777

申请日：1996-01-11

Applicant: Hiroto Takesue ,  Tsugio Shimono

Inventor： Hiroto Takesue ,  Tsugio Shimono

IPC: G01N21/15 ,  G01N21/17 ,  G01N21/77 ,  G02B6/02 ,  G02B6/032 ,  G02B6/00

CPC classification number: G02B6/032 ,  G01N21/03 ,  G01N21/05 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An intra-liquid optical measuring sensor is provided having an optical fiber including a cladding in the form of a hollow tube, and a core. The core includes both a solid portion, and a liquid portion at an end of the core, which latter portion serves as the sensing portion of the fiber. The liquid portion has a light transmitting liquid substance therein.

Abstract translation: 提供一种液晶内光学测量传感器，其具有包括中空管形式的包层的光纤和芯。 芯部包括固体部分和在芯部的端部处的液体部分，后者部分用作纤维的感测部分。 液体部分在其中具有透光液体物质。

公开(公告)号：US11656179B2

公开(公告)日：2023-05-23

申请号：US17380459

申请日：2021-07-20

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji Tajima

IPC: G01N21/64 ,  G01N35/04 ,  G01N35/02 ,  G02B21/00 ,  G01N21/76 ,  G01N21/25 ,  C12Q1/686 ,  G01N21/11 ,  G01N35/10 ,  G01N21/27

CPC classification number: G01N21/6428 ,  C12Q1/686 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/02 ,  G01N35/04 ,  G02B21/002 ,  G01N21/11 ,  G01N21/276 ,  G01N21/6456 ,  G01N35/026 ,  G01N35/028 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2021/6484 ,  G01N2035/0403 ,  G01N2201/0846 ,  G01N2201/0853

Abstract: An optical measurement device is provided. The device includes first and second optical fibers; first and second reaction vessels, and a light guide stage coupled to the first and second optical fibers. The light guide stage is driven to simultaneously optically connect the first and second optical fibers with the first and second reaction vessels. The device includes a measurement device for receiving emissions from the first and second reaction vessels, and a connecting end arranging body that supports the first and second optical fibers along a path. The arranging body is driven along the path between a first position, in which the first optical fiber is optically connected with the measurement device so that light is transmittable from the first reaction vessel, and a second position, in which the second optical fiber is optically connected with the measurement device so that light is transmittable from the second reaction vessel.

公开(公告)号：US20180306827A1

公开(公告)日：2018-10-25

申请号：US15961626

申请日：2018-04-24

Applicant: Lightwave Science, Inc.

Inventor： William Bryan Pierce, III ,  Jason D. Pierce

IPC: G01N33/94 ,  G01N21/84 ,  G01J3/28 ,  G01N21/25 ,  G01N21/35 ,  G01N21/3563

CPC classification number: G01N33/948 ,  G01J3/0218 ,  G01J3/2803 ,  G01N21/255 ,  G01N21/35 ,  G01N21/3554 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/84 ,  G01N33/5097 ,  G01N2021/4742 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0692 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/129

Abstract: A system including a light source, sampling tray, and a plurality of fiber optics positioned to achieve high contrast to improve accuracy and eliminate the need to rotate the sample. A composite light image from the fiber optics is fed to a spectrometer which converts the reflected light into a fingerprint corresponding to the concentration of at least one substance in the sample. The fingerprint is processed by a statistical model to determine concentration level of the at least one substance in the sample and the concentration level is then displayed.

公开(公告)号：US20180257077A1

公开(公告)日：2018-09-13

申请号：US15867450

申请日：2018-01-10

Applicant: BioAccel

Inventor： Frederic ZENHAUSERN ,  Alan NORDQUIST ,  Ralf LENIGK ,  Cedric HURTH ,  Jianing YANG ,  Xiaojia CHEN ,  John LEE-EDGHILL ,  Nina MORAN ,  Andrew HOPWOOD ,  Pieris KOUMI

IPC: B01L3/00 ,  G01N27/447 ,  B01L7/00 ,  C25B9/00 ,  G01N21/64 ,  G01N21/01 ,  G01N1/10 ,  C12Q1/6806

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.

公开(公告)号：US09921164B2

公开(公告)日：2018-03-20

申请号：US15418350

申请日：2017-01-27

Applicant: UVic Industry Partnerships Inc.

Inventor： Tao Lu

IPC: G01N21/65 ,  G02B6/032 ,  G02B6/255

CPC classification number: G01N21/658 ,  G01N21/65 ,  G01N2201/0612 ,  G01N2201/08 ,  G01N2201/0846 ,  G02B6/032 ,  G02B6/2551 ,  G02B6/2821 ,  G02B6/2856

Abstract: A system and a method for optical sensing of single molecule or molecules in various concentrations are provided. The optical sensor system comprises a first fiber, a second fiber, a light source and a detection device. The first fiber and the second fiber are fused together to form an optical coupler. The first fiber serves as the passageway for the analyte, while the second fiber serves as the waveguide for the light that will interact with the said analyte. One end of the second fiber is connected to the light source (e.g. laser), and the opposite end is connected to the detection device (e.g. spectrometer). The analyte is introduced into the first fiber through one of its ends, and is allowed to flow through inside the hollow core of the said first fiber. When light is delivered through the input end of the second fiber, the evanescent light is formed in the optical coupler and is allowed to interact with the analyte in the first fiber. One scenario in this analyte-light interaction results in, for example, the generation of Raman emission that is used as the probing signal. The spectrum of the Raman emission is analyzed by the detection device to determine the presence of target molecule.

公开(公告)号：US20170328770A1

公开(公告)日：2017-11-16

申请号：US15592274

申请日：2017-05-11

Applicant: OCEAN OPTICS, INC.

Inventor： THOMAS HOPKINS ,  DIETER BINGEMANN ,  DAVID CREASEY

IPC: G01J3/02 ,  G01N33/02

CPC classification number: G01J3/0218 ,  G01N21/49 ,  G01N21/55 ,  G01N21/8806 ,  G01N33/02 ,  G01N2201/0846

Abstract: A food integrity probe design comprising two illumination fiber rings, allowing for two different simultaneous measurements wherein the inner illumination ring generates a surface reflectance signal on the central detection fibers and the outer illumination ring allows for an additional interactance measurement, probing deeper into the sample than the surface reflectance alone while partially eliminating specular reflection, which reduces the signal quality, through the addition of a ring-shaped diffusor onto the inner illumination ring is disclosed.

公开(公告)号：US20170176320A1

公开(公告)日：2017-06-22

申请号：US15379546

申请日：2016-12-15

Applicant: rap.ID Particle Systems GMBH

Inventor： Karsten GOEDE ,  Lothar HOLZ ,  Markus LANKERS ,  Oliver K. VALET

IPC: G01N21/03 ,  G01N33/483 ,  G01N21/65

CPC classification number: G01N21/03 ,  G01J3/44 ,  G01N21/65 ,  G01N33/483 ,  G01N2021/0385 ,  G01N2021/0389 ,  G01N2201/0846 ,  G01N2201/10

Abstract: The invention relates to a system (1) for confocal Raman-spectroscopic measurements, comprising at least the following components: a sample chamber (10), wherein said sample chamber (10) is configured to house a sample (2) in a closed chamber volume (12) of the sample chamber (10), an excitation light source (3), an objective lens (4), configured to focus excitation light (32) of the excitation light source (3) through a ceiling portion (11) of the sample chamber (10) in a focal volume (31) in the chamber volume (12) and to collect inelastically scattered light (33) stemming from the focal volume (31), a confocal detection arrangement (20), comprising means for a confocal detection (22, 23) of a Raman signal comprised in the inelastically scattered light (33) from the focal volume (31), and a detector (21) that is configured to detect and to record said Raman signal, wherein the distance (5) between the ceiling portion (11) of the sample chamber (10) and the focal volume (31) is greater than one millimetre during operation of the system (1).

公开(公告)号：US20170087553A1

公开(公告)日：2017-03-30

申请号：US15255406

申请日：2016-09-02

Applicant: WHITESPACE ENTERPRISE CORPORATION

Inventor： Frederic ZENHAUSERN ,  Alan NORDQUIST ,  Ralf LENIGK ,  Cedric HURTH ,  Jianing YANG ,  Xiaojia CHEN ,  Matthew ESTES ,  John LEE-EDGHILL ,  Nina MORAN ,  Andrew HOPWOOD ,  Pieris KOUMI ,  Zhi CAI

IPC: B01L3/00 ,  G01N21/64 ,  B01L7/00 ,  G01N27/447 ,  C12Q1/68 ,  G01N1/10

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

公开(公告)号：US09540701B2

公开(公告)日：2017-01-10

申请号：US14631917

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Jonathon Todd Olesberg ,  Mark Allen Arnold ,  Gary Wray Small ,  Edwin John Koerperick ,  Christine Esther Evans

IPC: C12Q3/00 ,  G01N21/359 ,  G01N21/39 ,  G01N21/3577 ,  G01N21/31 ,  G01N21/51 ,  G01N21/64 ,  G01N21/65

CPC classification number: C12Q3/00 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/51 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/399 ,  G01N2201/067 ,  G01N2201/0846

Abstract: A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Abstract translation: 通过近红外（NIR）光谱进行连续，实时过程监测和控制的系统和方法提供了静态或流动的流体流的分析，其可以从清楚到高度光密度，包括主要是含水组成的流体。 NIR源通过波长选择器以选择一个或多个光谱段，其在流体采样接口处通过流体流并在传感器处接收。 波长参考材料位于用于校准的光路中。 可以对包含在其中的流体和悬浮固体或细胞的多个特征或参数进行定量。 光学系统的全固态实现确保了实验室和工业环境中的高稳定性。