System and method for detecting target materials using a VIS-NIR detector

    公开(公告)号:US10317282B2

    公开(公告)日:2019-06-11

    申请号:US15401716

    申请日:2017-01-09

    Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

    Increased processing efficiency for optical spectral analyzers

    公开(公告)号:US10295406B2

    公开(公告)日:2019-05-21

    申请号:US15638829

    申请日:2017-06-30

    Abstract: An optical spectral analyzer for measuring an optical multi-channel signal by separating the multi-channel signal and measuring a plurality of single-channel signals simultaneously. The spectral analyzer can include a demultiplexer configured to receive the multi-channel signal. The multi-channel signal can be a multi-channel wavelength range. The demultiplexer can separate the multi-channel signal into the plurality of single-channel signals including a first single-channel signal and a second single-channel signal. The spectral analyzer can include a plurality of optical paths. The plurality of optical paths can include a plurality of respective detectors for measuring an optical power of the respective single-channel signals. The detectors can convert the optical power of the respective single-channel signals to corresponding electrical signals. In some examples, the spectral analyzer includes a controller configured to obtain the plurality of respective electrical signals simultaneously to correspondingly detect the optical power of the multi-channel signal across the multi-channel wavelength range.

    Quantum yield calculation method, spectrophotofluorometer, and quantum yield calculation program

    公开(公告)号:US10267681B2

    公开(公告)日:2019-04-23

    申请号:US15951885

    申请日:2018-04-12

    Abstract: A quantum yield calculation method uses a quantum yield calculation program for a spectrophotofluorometer. When a quantum yield is calculated using a spectrophotofluorometer 1, a calibration processing unit executes the processing to calibrate a photon number A2 that is a photon number of the fluorescence in a blank measurement state based on a photon number A1 that is the photon number of an excitation light in the blank measurement state and a photon number B1 that is the photon number of an excitation light in the sample measurement state. A quantum yield calculation processing unit calculates a first quantum yield based on a background photon number A2′ after a calibration in addition to the photon number A1 of the excitation light in the blank measurement state and the photon number B2 of the fluorescence in the sample measurement state.

    Fluorescence microscope light source apparatus and fluorescence microscope

    公开(公告)号:US10209503B2

    公开(公告)日:2019-02-19

    申请号:US15695464

    申请日:2017-09-05

    Abstract: Disclosed are a fluorescence microscope light source apparatus and a fluorescence microscope capable of obtaining high-luminance light in a wavelength of 500 to 550 nm and having reduced background noise when a sample is observed. The fluorescence microscope light source apparatus to be installed in a fluorescence microscope including an illumination light bandpass filter includes: a laser diode that emits blue light as excitation light; a phosphor that converts the excitation light from the laser diode into illumination fluorescence with a wavelength region of 500 to 550 nm; an optical system that extracts the illumination fluorescence from the phosphor; a first condenser lens that condenses the excitation light onto the phosphor; a light guide body having one end face on which the illumination fluorescence is incident and the other end face from which the illumination fluorescence exits; and a second condenser lens that condenses the illumination fluorescence onto the one end face of the light guide body. A band-elimination filter that blocks or attenuates light, out of the illumination fluorescence, in a wavelength region including a transmission maximum wavelength and including no transmission minimum wavelength in the illumination light bandpass filter is provided on a light path of the illumination fluorescence.

    ON-CHIP SPECTROMETER EMPLOYING PIXEL-COUNT-MODULATED SPECTRAL CHANNELS AND METHOD OF MANUFACTURING THE SAME

    公开(公告)号:US20190041263A1

    公开(公告)日:2019-02-07

    申请号:US16051834

    申请日:2018-08-01

    Inventor: Byung IL CHOI

    Abstract: An array of sensor pixels is formed on a substrate, and a signal processing unit is connected to the array of sensor pixels. The signal processing unit includes multiple spectral channels that are defined by a respective transmission curve of each optical filter of at least one associated sensor pixel. Each of the sensor pixels includes a stack of a respective photodetector and a respective optical filter. Each spectral channel receives an output signal from one or more sensor pixels including an optical filter having the same transmission curve. At least one spectral channel has a greater number of sensor pixels than another spectral channel among the multiple spectral channels. The different number of pixels for the spectral channels can be employed to compensate for variations of sensor efficiency as a function of wavelength. Adjustment to sensor gain can be minimized through use of different number of pixels for different spectral channels.

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