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公开(公告)号：US09492670B2
公开(公告)日：2016-11-15
申请号：US11923933
申请日：2007-10-25
Applicant: Brian Mech , Robert J. Greenberg , Honggang Jiang
Inventor： Brian Mech , Robert J. Greenberg , Honggang Jiang
CPC classification number: A61N1/37205 , A61N1/05 , A61N1/372 , A61N1/375 , C23C14/081 , C23C14/28
Abstract: An implantable micro-miniature device is disclosed. The device comprises a thin hermetic insulating coating and at least one thin polymer or metal secondary coating over the hermetic insulating layer in order to protect the insulating layer from the erosive action of body fluids or the like. In one embodiment the insulating layer is ion beam assisted deposited (IBAD) alumina and the secondary coating is a parylene polymer. The device may be a small electronic device such as a silicon integrated circuit chip. The thickness of the insulating layer may be ten microns or less and the thickness of the secondary layer may be between about 0.1 and about 15 microns.
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公开(公告)号：US09095722B2
公开(公告)日：2015-08-04
申请号：US11343170
申请日：2006-01-30
Applicant: Brian Mech , Robert J. Greenberg , Honggang Jiang
Inventor： Brian Mech , Robert J. Greenberg , Honggang Jiang
CPC classification number: A61N1/37205 , A61N1/05 , A61N1/372 , A61N1/375 , C23C14/081 , C23C14/28
Abstract: An implantable micro-miniature device is disclosed. The device comprises a thin hermetic insulating coating and at least one thin polymer or metal secondary coating over the hermetic insulating layer in order to protect the insulating layer from the erosive action of body fluids or the like. In one embodiment the insulating layer is ion beam assisted deposited (IBAD) alumina and the secondary coating is a parylene polymer. The device may be a small electronic device such as a silicon integrated circuit chip. The thickness of the insulating layer may be ten microns or less and the thickness of the secondary layer may be between about 0.1 and about 15 microns.
Abstract translation: 公开了一种可植入微型装置。 该装置包括薄的气密绝缘涂层和在密封绝缘层上的至少一个薄聚合物或金属二次涂层，以保护绝缘层免受体液等的侵蚀作用。 在一个实施例中，绝缘层是离子束辅助沉积（IBAD）氧化铝，第二涂层是聚对二甲苯聚合物。 该器件可以是诸如硅集成电路芯片的小型电子器件。 绝缘层的厚度可以为10微米或更小，并且第二层的厚度可以在约0.1至约15微米之间。
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公开(公告)号：US20080051862A1
公开(公告)日：2008-02-28
申请号：US11923933
申请日：2007-10-25
Applicant: Brian Mech , Robert Greenberg , Honggang Jiang
Inventor： Brian Mech , Robert Greenberg , Honggang Jiang
CPC classification number: A61N1/37205 , A61N1/05 , A61N1/372 , A61N1/375 , C23C14/081 , C23C14/28
Abstract: An implantable micro-miniature device is disclosed. The device comprises a thin hermetic insulating coating and at least one thin polymer or metal secondary coating over the hermetic insulating layer in order to protect the insulating layer from the erosive action of body fluids or the like. In one embodiment the insulating layer is ion beam assisted deposited (IBAD) alumina and the secondary coating is a parylene polymer. The device may be a small electronic device such as a silicon integrated circuit chip. The thickness of the insulating layer may be ten microns or less and the thickness of the secondary layer may be between about 0.1 and about 15 microns.
Abstract translation: 公开了一种可植入微型装置。 该装置包括薄的气密绝缘涂层和在密封绝缘层上的至少一个薄聚合物或金属二次涂层，以保护绝缘层免受体液等的侵蚀作用。 在一个实施例中，绝缘层是离子束辅助沉积（IBAD）氧化铝，第二涂层是聚对二甲苯聚合物。 该器件可以是诸如硅集成电路芯片的小型电子器件。 绝缘层的厚度可以为10微米或更小，并且第二层的厚度可以在约0.1至约15微米之间。
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公开(公告)号：US20070265665A1
公开(公告)日：2007-11-15
申请号：US11821328
申请日：2007-06-21
Applicant: Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech
Inventor： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech
IPC: A61N1/18
CPC classification number: A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.
Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。
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公开(公告)号：US20060271124A1
公开(公告)日：2006-11-30
申请号：US11499536
申请日：2006-08-04
Applicant: Robert Greenberg , Neil Talbot , Brian Mech , James Little
Inventor： Robert Greenberg , Neil Talbot , Brian Mech , James Little
CPC classification number: A61N1/0543 , A61N1/36046
Abstract: The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.
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Patent Agency Ranking
公开(公告)号：US20060259112A1
公开(公告)日：2006-11-16
申请号：US11413689
申请日：2006-04-28
Applicant: Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Ann Ripley
Inventor： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Ann Ripley
IPC: A61N1/05
CPC classification number: H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
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公开(公告)号：US10667404B2
公开(公告)日：2020-05-26
申请号：US11926046
申请日：2007-10-28
Applicant: Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
Inventor： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
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8.发明申请Method of forming an implantable electronic device chip level hermetic and biocompatible electronics package using SOI wafers 审中-公开使用SOI晶片形成可植入电子器件芯片级密封和生物兼容电子封装的方法公开(公告)号：US20080090322A1
公开(公告)日：2008-04-17
申请号：US11893153
申请日：2007-08-15
Applicant: Brian Mech , Robert Greenberg , Gregory Delmain
Inventor： Brian Mech , Robert Greenberg , Gregory Delmain
IPC: H01L31/00
CPC classification number: H01L21/76251 , H01L21/84 , H01L27/1203
Abstract: The invention is directed to a hermetically packaged and implantable integrated circuit for electronics that is made my producing streets in silicon-on-insulator chips that are subsequently coated with a selected electrically insulating thin film prior to completing the dicing process to yield an individual chip. A thin-layered circuit may transmit light, allowing a photodetector to respond to transmitted light to stimulate a retina, for example. Discrete electronic components may be placed in the three-dimensional street area of the integrated circuit package, yielding a completely integrated hermetic package that is implantable in living tissue.
Abstract translation: 本发明涉及一种用于电子设备的气密封装和可植入集成电路，其使得我的绝缘体上硅芯片中的生产街道随后在完成切割过程之前涂覆选定的电绝缘薄膜以产生单个芯片。 薄层电路可以透射光，例如允许光电检测器响应透射光以刺激视网膜。 离散电子部件可以放置在集成电路封装的三维街区中，产生可植入生物体组织中的完全集成的密封包装。
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公开(公告)号：US20070270919A1
公开(公告)日：2007-11-22
申请号：US11880009
申请日：2007-07-19
Applicant: Robert Greenberg , Neil Talbot , Brian Mech , James Little
Inventor： Robert Greenberg , Neil Talbot , Brian Mech , James Little
IPC: A61N1/05
CPC classification number: A61N1/0543 , A61N1/36046
Abstract: The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.
Abstract translation: 本发明是具有改进的构造的视网膜假体，其将眼睛内部和周围的必要部件安装。 本发明更好地允许在精细的眼睛结构内植入电子装置。 本发明通过使用巩膜外部的多路复用器和巩膜内部的解复用器进一步限制穿过巩膜的薄膜导体的必要宽度。
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公开(公告)号：US20060247754A1
公开(公告)日：2006-11-02
申请号：US11207644
申请日：2005-08-19
Applicant: Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
Inventor： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC: A61N1/05
CPC classification number: H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
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