公开(公告)号：US20240054616A1

公开(公告)日：2024-02-15

申请号：US18253607

申请日：2021-11-18

Applicant: LEICA MICROSYSTEMS INC.

Inventor： Hansford HENDARGO

IPC: G06T5/00 ,  G06T5/10 ,  G06T11/00

CPC classification number: G06T5/002 ,  G06T5/10 ,  G06T11/008 ,  G06T2207/10101 ,  G06T2207/20056 ,  G06T2207/30041

Abstract: The invention relates to a control system for controlling optical coherence tomography imaging means for imaging a subject, the control system being configured to perform the following steps of an imaging process: receiving (212) a scan data set from the subject being acquired by means of optical coherence tomography, the scan data set including one or several spectra (270), performing (214) data processing on the spectrum or on each of the several spectra of the scan data set (122), including per spectrum: determining (216) a scaling factor (274) for the spectrum (270, 370, 372, 374), scaling (218) a baseline spectrum (272) with a scaling factor (274), and removing (220) the scaled baseline spectrum (276) from the spectrum (270); and providing (224) a baseline corrected image data set of the subject for an image of the subject to be displayed, to an optical coherence tomography imaging system and to a corresponding method.

公开(公告)号：US20030127992A1

公开(公告)日：2003-07-10

申请号：US10041055

申请日：2002-01-07

Applicant: Leica Microsystems Inc.

Inventor： David J. Cash

IPC: H05B037/02

CPC classification number: H05B39/02

Abstract: An apparatus for gradually supplying power to a source of illumination in a microscope, including a power transistor operatively arranged to provide a varying applied voltage to the source of illumination, and, means for biasing the power transistor with a pulse width modulated signal to incrementally increase the applied voltage to the source of illumination in a plurality of discrete steps. The invention also includes a method for gradually supplying power to a source of illumination in a microscope by biasing a power transistor with a pulse width modulated signal to incrementally increase the applied voltage to the source of illumination in a plurality of discrete steps.

Abstract translation: 一种用于在显微镜中逐渐向照明源供电的装置，包括可操作地布置成向照明源提供变化的施加电压的功率晶体管，以及用于以脉冲宽度调制信号偏置功率晶体管以逐渐增加的装置 在多个离散步骤中施加到照明源的电压。 本发明还包括一种用于通过利用脉冲宽度调制信号偏置功率晶体管来逐渐向显微镜中的照明源供电的方法，以在多个离散步骤中逐渐增加施加到照明源的电压。

公开(公告)号：US20030127991A1

公开(公告)日：2003-07-10

申请号：US10040566

申请日：2002-01-07

Applicant: Leica Microsystems Inc.

Inventor： David J. Cash ,  VINCENT VACCARELLI

IPC: G05F001/00

CPC classification number: G02B21/06

Abstract: An apparatus for automatically turning off a source of illumination in a microscope, comprising a switch operatively arranged to control the illumination source, and means for sensing inactivity of the switch and for turning off the illumination source after a predetermined time period of inactivity. The invention also includes a method for automatically turning off a source of illumination in a microscope, comprising the steps of monitoring activity of a switch operatively arranged to control the illumination source, and, turning off the illumination source after a predetermined time period of inactivity.

Abstract translation: 一种用于在显微镜中自动关闭照明源的装置，包括可操作地布置成控制照明源的开关，以及用于感测开关的不活动并且在预定时间段不活动之后关闭照明源的装置。 本发明还包括一种用于在显微镜中自动关闭照明源的方法，包括以下步骤：监测可操作地布置成控制照明源的开关的活动，以及在预定的不活动时间段之后关闭照明源。

公开(公告)号：US20030088170A1

公开(公告)日：2003-05-08

申请号：US09993281

申请日：2001-11-06

Applicant: Leica Microsystems Inc.

Inventor： Bruce Siskowski ,  David A. Luce

IPC: A61B003/16

CPC classification number: A61B3/165

Abstract: A non-contact tonometer comprises a fluid pump system configured and mounted to dissipate vibration energy to reduce the effect of vibrations on measurement components caused by the stroke of a piston with respect to a cylinder in the fuid pump system. In a preferred embodiment, a compression chamber receiving a piston and plenum chamber containing a pressure sensing device are spaced apart from one another and connected by a flow tube formed of a vibration damping material, and at least one vibration damping element is provided between the cylinder and a support frame of the non-contact tonometer.

Abstract translation: 非接触式眼压计包括流体泵系统，其被构造和安装成消散振动能量，以减少由活塞相对于引导泵系统中的气缸引起的对测量部件的振动的影响。 在优选实施例中，容纳具有压力感测装置的活塞和增压室的压缩室彼此隔开并通过由减振材料形成的流动管连接，并且至少一个减振元件设置在气缸 和非接触眼压计的支撑框架。

公开(公告)号：US20030086059A1

公开(公告)日：2003-05-08

申请号：US09992756

申请日：2001-11-06

Applicant: Leica Microsystems Inc.

Inventor： Christopher J. Percival ,  Douglas H. Hoover

IPC: A61B003/14

CPC classification number: A61B3/113 ,  A61B3/1208 ,  A61B3/165

Abstract: An alignment system for an ophthalmic instrument comprises an optical axis along which an operator can directly view the patient's eye and the patient can fixate on a dark fixation target surrounded by a bright background that helps to illuminate the eye for operator viewing. A position detection system utilizing stored geometrical relationships determined by multiple regression during instrument calibration computes X-Y-Z alignment status of the instrument relative to a patient's eye based on local x-y position information from a pair of lateral detectors receiving corneally reflected light from a corresponding pair of lateral light sources. A heads-up display image is provided along an optical axis of the instrument for supplying instructive cues to an operator for moving the instrument to achieve alignment based on signal information from the position detection system, whereby the operator sees both a direct macro-image of the patient's eye and the display image. The alignment system is particularly suitable for use in handheld ophthalmic instruments.

Abstract translation: 用于眼科器械的对准系统包括光轴，操作者可沿着该轴线直接观察患者的眼睛，并且患者可以固定在由明亮背景围绕的暗固定目标上，该暗视觉目标有助于照亮眼睛以供操作者观察。 利用在仪器校准中由多重回归确定的存储的几何关系的位置检测系统基于来自一对横向检测器的局部xy位置信息来计算仪器相对于患者眼睛的XYZ对准状态，所述横向检测器接收来自相应的一对侧向光的角膜反射光 来源。 沿着仪器的光轴提供平视显示图像，用于向操作者提供用于移动仪器的指示线索，以基于来自位置检测系统的信号信息来实现对准，由此操作者同时看到直接的宏观图像 患者的眼睛和显示图像。 对准系统特别适用于手持式眼科仪器。

公开(公告)号：US20220125301A1

公开(公告)日：2022-04-28

申请号：US17424056

申请日：2020-03-19

Applicant: Leica Microsystems Inc.

Inventor： Robert H. Hart ,  Dorothy M. Branco ,  Eric L. Buckland ,  Micaela R. Mendlow

IPC: A61B3/10 ,  A61B3/00 ,  G06T7/33

Abstract: Systems for determining an apex of curvature In an image, obtained from, a sample are provided. The systems include—an imaging system configured to obtain a plurality of scans of a sample using a radial pattern; and a processor associated with the imaging system. The processor is configured to segment and curve fit each of the plurality of scans to a surface of the sample; determine an apex. for each curve associated with each of the plurality of scans; determine a true apex, among all determined apexes using a derivative of least value; calculate an XY offset based on the determined true apex; map the true apex to an origin where X and Y are equal to zero; and adjust the coordinates associated with remaining apexes not determined to be the true apex based on the calculated offset.

公开(公告)号：US20040109238A1

公开(公告)日：2004-06-10

申请号：US10313721

申请日：2002-12-05

Applicant: Leica Microsystems Inc.

Inventor： Keshav D. Sharma

IPC: G02B021/02 ,  G02B009/60

CPC classification number: G02B9/34 ,  G02B21/02

Abstract: This invention relates to a microscope having an infinity-corrected objective and providing a flat field of view. The present invention is an optical arrangement that broadly comprises a first lens element having positive power and comprising at least one lens, a second lens element having negative power and comprising at least one lens, a third lens element having positive power and comprising at least one lens, a fourth lens element having positive power and comprising at least one lens, and a fifth lens element comprising at least one lens and having positive power, and, in addition comprising a configuration in which the radius of curvature of the surface of the fifth lens element proximate to the object plane is less than the radius of curvature of the surface of the fifth lens element distal to the object plane, with the optical arrangement arrayed such that the distance from the first lens element to the second lens element is sufficient to reduce a ray height of a light ray entering the second lens element from the ray height of the same light ray entering said first lens element.

Abstract translation: 本发明涉及具有无穷远校正物镜并提供平坦视场的显微镜。 本发明是一种光学装置，其广泛地包括具有正功率的第一透镜元件，并且包括至少一个透镜，具有负光焦度并包括至少一个透镜的第二透镜元件，具有正光焦度的第三透镜元件，并且包括至少一个透镜 透镜，具有正功率并且包括至少一个透镜的第四透镜元件和包括至少一个透镜并具有正光焦度的第五透镜元件，并且还包括其中第五透镜的表面的曲率半径 靠近物平面的透镜元件小于远离物面的第五透镜元件的表面的曲率半径，其中光学排列使得从第一透镜元件到第二透镜元件的距离足以 从进入所述第一透镜元件的相同光线的射线高度减小进入第二透镜元件的光线的射线高度。

公开(公告)号：US20030090630A1

公开(公告)日：2003-05-15

申请号：US10037326

申请日：2001-11-09

Applicant: Leica Microsystems Inc.

Inventor： David Biggins ,  Douglas H. Hoover ,  Carl E. Hynes ,  Donald E. Miller

IPC: A61B003/02

CPC classification number: A61B3/0285

Abstract: A subjective ophthalmic refractor is improved for operator visibility in a darkened examination room by forming a cylinder axis scale of the refractor as a light-transmitting component having opaque scale gradations and installing a polar array of illumination sources to project light through the cylinder axis scale, which preferably includes a translucent material for diffuse illumination. In an alternative embodiment, the cylinder axis scale includes a photoluminescent material to which the scale gradations are applied. The refractor is further improved by installing respective illumination sources near a cylinder power readout and a sphere power readout of the refractor. The disclosure additionally relates to a method for retrofitting an ophthalmic refractor to illuminate the cylinder axis scale, cylinder power readout, and sphere power readout.

公开(公告)号：US20230414096A1

公开(公告)日：2023-12-28

申请号：US18253604

申请日：2021-11-18

Applicant: Leica Microsystems Inc.

Inventor： Hansford Hendargo

IPC: A61B3/10 ,  A61B3/15

CPC classification number: A61B3/102 ,  A61B3/152

Abstract: The invention relates to a control system (130) for controlling optical coherence tomography imaging means for imaging a subject (190), the control system being configured to perform the following steps: receiving scan data (122) from the subject (190) being acquired by means of optical coherence tomography, performing data processing on the scan data (122), and obtaining image data (142) for an image (144) of the subject, and the processing system (130) further being configured to adapting, based on a change of a value, the value characterizing an axial position (z) of the subject (190) with respect to the OCT imaging means, between two sets of image data, at least one parameter of the OCT imaging means, to a processing system, to an OCT imaging system (100) and a corresponding method.

公开(公告)号：US20230301507A1

公开(公告)日：2023-09-28

申请号：US18019522

申请日：2021-07-30

Applicant: LEICA MICROSYSTEMS INC.

Inventor： Eric LYNCH ,  John PERNG

IPC: A61B3/10 ,  A61B3/14

CPC classification number: A61B3/102 ,  A61B3/145

Abstract: The invention relates to a control system (130) for an imaging system (100) for real-time imaging of a subject (190), using optical coherence tomography and video imaging, the control system (130) being configured to: control the imaging system (100) to determine, from a video image (152) of the subject (190), a position and/or an orientation (152) of a tissue of interest (192) in the subject (190), control the imaging system (100) to perform a scan of the subject (190) by means of optical coherence tomography, wherein a position and/or an orientation (144) of the scan is determined based on the position and/or orientation (154) of the tissue of interest (192) in the video image (152), and provide an optical coherence tomography image (142) of the subject (190), including the tissue of interest (192), based on the scan, to an imaging system (100) and a corresponding method.