公开(公告)号：US20240099612A1

公开(公告)日：2024-03-28

申请号：US18368296

申请日：2023-09-14

Applicant: ABBOTT DIABETES CARE INC. ,  Abbott Diabetes Care Inc.

Inventor： Erwin S. Budiman ,  Hyun Cho

IPC: A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14546 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  A61B2560/045 ,  A61B2560/0462 ,  A61B2560/06

Abstract: Systems, devices, and methods for a dual analyte sensor using glucose history from a glucose sensor in combination with data from a ketone sensor to control operation of a user interface device or insulin pump are provided. In some embodiments, the systems, apparatus or methods may make use of combination of glucose history and a β-hydroxybutyrate physiological model to better predict diabetic ketoacidosis (DKA), in comparison to a prediction based on a simple high glucose threshold. In other embodiments, the systems, apparatus or method may include features for generating an estimate of the patient's medication state and/or knowledge of medication information, such as a patient with T1 diabetes mellitus (DM) using an SGLT-2 inhibitor.

公开(公告)号：US12290359B2

公开(公告)日：2025-05-06

申请号：US17138477

申请日：2020-12-30

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Yi Wang ,  Hyun Cho ,  Benjamin J. Feldman ,  Kuan-Chou Chen ,  Lam N. Tran ,  Stephen Oja ,  Tianmei Ouyang

IPC: A61B5/1486 ,  A61B5/145

Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

公开(公告)号：US12268496B2

公开(公告)日：2025-04-08

申请号：US17357090

申请日：2021-06-24

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Vivek S. Rao ,  Louis G. Pace ,  Hyun Cho ,  Benjamin Jay Feldman ,  Yi Wang ,  Tuan Nguyen

IPC: A61B5/145 ,  A61B5/00 ,  A61B17/34

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

公开(公告)号：US20220386910A1

公开(公告)日：2022-12-08

申请号：US17819099

申请日：2022-08-11

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Stephen OJA ,  Tianmei Ouyang ,  Hyun Cho ,  Lam N. Tran ,  Benjamin J. Feldman ,  Mark K. Sloan ,  AShwin Kumar ,  Namvar Kiaie ,  Michael R. Love

IPC: A61B5/1486 ,  A61B5/145 ,  C12Q1/00

Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.

公开(公告)号：US20220007973A1

公开(公告)日：2022-01-13

申请号：US17357090

申请日：2021-06-24

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Vivek S. Rao ,  Louis G. Pace ,  Hyun Cho ,  Benjamin Jay Feldman ,  Yi Wang ,  Tuan Nguyen

IPC: A61B5/145 ,  A61B17/34 ,  A61B5/00

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

公开(公告)号：US20200241015A1

公开(公告)日：2020-07-30

申请号：US16582583

申请日：2019-09-25

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Benjamin J. Feldman ,  Hyun Cho

IPC: G01N33/70 ,  C12Q1/34 ,  C12Q1/00 ,  C12Q1/26 ,  G01N27/327

Abstract: Creatinine levels may be monitored as a measure of kidney function. Conventionally, blood and/or urine tests are used for this purpose. Analyte sensors capable of monitoring creatinine in vivo may comprise: a sensor tail comprising at least a first working electrode, a creatinine-responsive active area disposed upon a surface of the first working electrode, a first membrane that is permeable to creatinine and overcoats the creatinine-responsive active area, and an oxygen scavenger located upon the sensor tail in proximity to the creatinine-responsive active area. The creatinine-responsive active area comprises a first electron transfer agent, a first polymer, and an enzyme system comprising multiple enzymes, particularly creatinine amidohydrolase, creatine amidohydrolase, and sarcosine oxidase, that are capable of acting in concert to facilitate detection of creatinine. An oxidase enzyme may serve as the oxygen scavenger, particularly glucose oxidase when detecting creatinine in fluids also containing glucose.

公开(公告)号：US10398363B2

公开(公告)日：2019-09-03

申请号：US15873464

申请日：2018-01-17

Applicant: Abbott Diabetes Care Inc.

Inventor： Gary A. Hayter ,  Daniel M. Bernstein ,  Martin J. Fennell ,  Michael R. Love ,  Kenneth J. Doniger ,  Songbiao Zhang ,  Mark K. Sloan ,  Hyun Cho ,  Theodore J. Kunich ,  Jean-Pierre Cole ,  Christopher A. Thomas ,  Erwin S. Budiman ,  David L. Li ,  Royce Cheng ,  Udo Hoss

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/01 ,  A61B5/00 ,  A61B5/1473

Abstract: Methods of compensating for ambient temperature using a single temperature sensor, the method comprising detecting a first temperature measurement from a temperature sensor; and determining, with a processor, an ambient-compensated temperature from the first temperature measurement using an offset term. The method may also include receiving a sensor signal from an in vivo analyte sensor; and determining, with a processor, a temperature-compensated analyte sensor signal with the ambient-compensated temperature.

公开(公告)号：US10285632B2

公开(公告)日：2019-05-14

申请号：US15659480

申请日：2017-07-25

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Udo Hoss ,  Benjamin J. Feldman ,  Zenghe Liu ,  Hyun Cho ,  Benjamin M. Rush

IPC: A61B5/1473 ,  A61B5/1468 ,  A61B5/145 ,  A61B5/00

Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

公开(公告)号：US10219728B2

公开(公告)日：2019-03-05

申请号：US14445750

申请日：2014-07-29

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Zenghe Liu ,  Hyun Cho ,  Benjamin J. Feldman

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/00

Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.

公开(公告)号：US20180289295A1

公开(公告)日：2018-10-11

申请号：US15945636

申请日：2018-04-04

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Udo Hoss ,  Craig W. Sharp ,  Hyun Cho ,  Todd Winkler ,  Paul Legg

IPC: A61B5/145

Abstract: An analyte monitoring system comprising: an on-body housing; an analyte sensor coupled to the housing; an electrical output interface disposed on an outer surface of the housing; and a removable adaptor coupled to the housing. In one embodiment, a portion of the analyte sensor extends from the housing for implantation into a patient's body. The electrical output interface is electrically coupled to the analyte sensor. The removable adaptor is mechanically coupled to the housing and electrically coupled to the electrical output interface. The removable adaptor serves as a data conduit between the analyte sensor and a remote device.