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    Analyte sensors employing multiple enzymes and methods associated therewith
    2.
    发明授权
    Analyte sensors employing multiple enzymes and methods associated therewith 有权

    公开(公告)号：US12048539B2

    公开(公告)日：2024-07-30

    申请号：US16774841

    申请日：2020-01-28

    Applicant: Abbott Diabetes Care Inc.

    Inventor： Stephen Oja ,  Tianmei Ouyang ,  Hyun Cho ,  Benjamin J. Feldman ,  Namvar Kiaie

    IPC: A61B5/1486 ,  A61B5/145 ,  C12Q1/00

    CPC classification number: A61B5/14865 ,  A61B5/14532 ,  C12Q1/002 ,  C12Q1/005 ,  G01N2333/9029 ,  G01N2333/904 ,  G01N2333/908

    Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.

    SYSTEMS, DEVICES, AND METHODS RELATED TO KETONE SENSORS
    5.
    发明申请
    SYSTEMS, DEVICES, AND METHODS RELATED TO KETONE SENSORS 有权

    公开(公告)号：US20220233116A1

    公开(公告)日：2022-07-28

    申请号：US17585499

    申请日：2022-01-26

    Applicant: ABBOTT DIABETES CARE INC.

    Inventor： Shridhara A. Karinka ,  Stephen Oja

    IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  A61B5/265 ,  A61B5/1473

    Abstract: Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with β-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.

    ANALYTE SENSORS AND SENSING METHODS FEATURING LOW-POTENTIAL DETECTION
    7.
    发明申请
    ANALYTE SENSORS AND SENSING METHODS FEATURING LOW-POTENTIAL DETECTION 有权

    公开(公告)号：US20210190719A1

    公开(公告)日：2021-06-24

    申请号：US17151296

    申请日：2021-01-18

    Applicant: Abbott Diabetes Care Inc.

    Inventor： John V. LaTour ,  Jonathan D. McCanless ,  Stephen Oja ,  Tianmei Ouyang ,  Kevin Paul Wallis ,  Benjamin J. Feldman ,  Udo Hoss ,  Suyue Qian

    IPC: G01N27/327

    Abstract: Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.

    Sensor array systems and methods for detecting multiple analytes
    9.
    发明授权
    Sensor array systems and methods for detecting multiple analytes 有权

    公开(公告)号：US12290359B2

    公开(公告)日：2025-05-06

    申请号：US17138477

    申请日：2020-12-30

    Applicant: ABBOTT DIABETES CARE INC.

    Inventor： Yi Wang ,  Hyun Cho ,  Benjamin J. Feldman ,  Kuan-Chou Chen ,  Lam N. Tran ,  Stephen Oja ,  Tianmei Ouyang

    IPC: A61B5/1486 ,  A61B5/145

    Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

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