公开(公告)号：US3910988A

公开(公告)日：1975-10-07

申请号：US40890173

申请日：1973-10-23

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

CPC classification number: A01N37/44 ,  Y10S514/929

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of

where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

Abstract translation: 包括选自-CH 2 -CH 2 -NH 2 |平行C-CH 2 -CH 2 -CH-C-OR PARALLEL | ONH 2的多巴胺的γ-谷氨酰胺的酯，其中R是C 1 -C 20烷基， 其药学上可接受的酸加成盐。 还涵盖使用所述多巴胺的γ-谷氨酰胺的酯通过临床上可接受的给药途径（例如口服，胃肠外，直肠等）将所述酰胺施用于温血哺乳动物来增加肾血流量。

公开(公告)号：US3906107A

公开(公告)日：1975-09-16

申请号：US28730472

申请日：1972-09-08

Applicant: ABBOTT LAB

Inventor： SOMANI PITAMBAR ,  MARTIN DONALD LYONS

IPC: A61K20060101 ,  A61K31/00 ,  A61K31/185 ,  A61K31/255 ,  C07C20060101

CPC classification number: A61K31/185 ,  Y10S514/869

Abstract: The present invention is directed to the provision of a therapeutically active composition having diuretic and renal vasodialator properties. The composition contains as its active ingredient a (substituted) aminoalkylsulfate ester. Such an ester is of extremely low toxicity and has a high therapeutic index.

Abstract translation: 本发明涉及提供具有利尿和肾血管扩张剂性质的治疗活性组合物。 该组合物含有（取代的）氨基烷基硫酸酯作为其活性成分。 这种酯的毒性极低，治疗指数高。