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    Esters of {65 -glutamyl amide of dopamine
    1.
    发明授权
    Esters of {65 -glutamyl amide of dopamine 失效
    多巴胺{65-谷氨酰胺的酯类

    公开(公告)号：US3910988A

    公开(公告)日：1975-10-07

    申请号：US40890173

    申请日：1973-10-23

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

    IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

    CPC classification number: A01N37/44 ,  Y10S514/929

    Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of

    where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

    Abstract translation: 包括选自-CH 2 -CH 2 -NH 2 |平行C-CH 2 -CH 2 -CH-C-OR PARALLEL | ONH 2的多巴胺的γ-谷氨酰胺的酯，其中R是C 1 -C 20烷基， 其药学上可接受的酸加成盐。 还涵盖使用所述多巴胺的γ-谷氨酰胺的酯通过临床上可接受的给药途径（例如口服，胃肠外，直肠等）将所述酰胺施用于温血哺乳动物来增加肾血流量。

    4{41 -Deoxy-4{41 -oxoerythromycin B derivatives
    2.
    发明授权
    4{41 -Deoxy-4{41 -oxoerythromycin B derivatives 失效
    4 {41-脱氧-4 {41-氧红霉素B衍生物

    公开(公告)号：US3884903A

    公开(公告)日：1975-05-20

    申请号：US50441774

    申请日：1974-09-09

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY ,  MARTIN JERRY ROY ,  MCALPINE JAMES BRUCE ,  PAUVLIK JEANNE MARIE ,  TADANIER JOHN SOLOMAN

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: Covers a 4''''-deoxy-4''''-oxoerythromycin compounds and derivatives thereof which are useful as antibiotics having a formula selected from the group consisting of:

    WHERE R is -CH2SR3, R2 is hydrogen or loweralkyl, R3 is loweralkyl, and R1 is hydrogen or loweralkanoyl;

    WHERE R1 and R2 are as before defined;

    WHERE R is hydrogen or CH3CO;

    where R1 is hydrogen or RCO, R is loweralkyl, R2 is hydrogen, CH3CO or RCO where R is loweralkyl; and

    WHERE R3 is hydrogen or RCO where R is loweralkyl.

    Abstract translation: 包含4' - 脱氧-4'-氧代红霉素化合物及其衍生物，其可用作具有选自以下的式的抗生素：

    2'-o-alkanoyl-4'-alkanoyloxy derivatives of erythromycin
    5.
    发明授权
    2'-o-alkanoyl-4'-alkanoyloxy derivatives of erythromycin 失效
    红霉素的2'-O-烷基-4'-烷氧基衍生物

    公开(公告)号：US3629232A

    公开(公告)日：1971-12-21

    申请号：US3629232D

    申请日：1969-08-19

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY

    IPC: C07H17/08 ,  C07C47/18

    CPC classification number: C07H17/08

    Abstract: THE 2''-O-ALKANOYL-4''-ALKANOYLOXY DERIVATIVES OF ERYTHROMYCIN A AND B ARE PREPARED BY REACTING 4''-HYDROXYERYTHROMYCIN A OR B WITH AN APPROPRIATE ACID ANHYDRIDE. THE RESULTING PRODCUTS HAVE ANTIBIOTIC ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS SMITH.

    Cyclic hydroxamic acids as antihypertensive agents
    6.
    发明授权
    Cyclic hydroxamic acids as antihypertensive agents 失效
    环状异羟肟酸作为抗高血压药

    公开(公告)号：US3895114A

    公开(公告)日：1975-07-15

    申请号：US33360073

    申请日：1973-02-20

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY ,  MARTIN YVONNE CONNOLLY

    IPC: A61K31/445 ,  A61K27/00

    CPC classification number: A61K31/445

    Abstract: Method of treating hypertension by administering to a hypertensive patient a therapeutically effective amount of a compound of the Formula

    WHEREIN R1, R2, and R3 each are hydrogen, alkyl, cycloalkyl or aryl.

    Abstract translation: 通过向高血压患者施用治疗有效量的式WHEREIN R1，R2和R3的化合物各自为氢，烷基，环烷基或芳基的治疗高血压的方法。

    11-Substituted erythromycin B derivatives
    7.
    发明授权
    11-Substituted erythromycin B derivatives 失效
    11-取代的红霉素B衍生物

    公开(公告)号：US3884904A

    公开(公告)日：1975-05-20

    申请号：US37238673

    申请日：1973-06-21

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY ,  MCALPINE JAMES BRUCE ,  PAUVLIK JEANNE MARIE ,  PERUN THOMAS JOHN

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: Covers 11-substituted erythromycin B derivatives having a formula selected from the group consisting of:

    WHERE R is selected from the group consisting of lower alkyl and -CHR3SR4 where R3 and R4 are loweralkyl, and R1 and R2 are hydrogen or loweralkyl and;

    WHERE R1, R2 and R3 are as before defined. Said erythromycin derivatives are useful as antibiotics or as intermediates useful in preparing other useful antibiotic compounds.

    Abstract translation: 覆盖具有选自以下的式的11-取代的红霉素B衍生物：

    Erythromycin ester derivatives
    9.
    发明授权
    Erythromycin ester derivatives 失效
    红霉素酯衍生物

    公开(公告)号：US3598805A

    公开(公告)日：1971-08-10

    申请号：US3598805D

    申请日：1970-02-26

    Applicant: ABBOTT LAB

    Inventor： JONES PETER HADLEY

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: THE 4''-HYDROXYVERYTHROMYCIN A AND B DERIVATIVES TOGETHER WITH ITS ACID-ADDITION SALTS HAVE BEEN FOUND TO HAVE ANTIBIOTIC ACTIVITY. THE COMPOUND HAS BEEN MADE BY OXIDATION OF ERYTHROMYCIN A OR B TO THE N OXIDE, FOLLOWED BY PYROLYSIS TO 3-(DEDIMETHYLAMINO)-$2''4''-ERYTHROMYCIN. THE UNSATURATE IS THEN EPOXIDIZED AND 3''-(DEDIMETHYLAMINO) - 3''-AZIDO-4''-HYDROXYVERYTHROMYCIN FORMED BY OPENING THE EPOXY RING WITH AN AZIDE. THE AZIDE IS THEN REDUCED TO 3''-(DEDIMETHYLAMINO)-3''-AMINO-4''-HYDROXYVERYTHROMYCIN, WHICH IS FURTHER REDUCED IN THE PRESENCE OF FORMALDEHYDE TO 4''-HYDROXYERYTHROMYCIN.

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