公开(公告)号：US3869445A

公开(公告)日：1975-03-04

申请号：US42365273

申请日：1973-12-10

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN SOLOMAN ,  VONESCH ANNE MARY

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Covers sulfonyl derivatives of erythromycin A, B and C falling within the following structural formula:

WHERE R is selected from the group consisting of amino, monoalkyl amino, dialkyl amino, alkoxy, morpholino, substituted morpholino, piperazino, substituted piperazino, piperidino, substituted piperidino, alkylthio, alkylsulfonyl, arylthio, substituted arylthio, arylsulfonyl, substituted arylsulfonyl, thiamorpholino, aziridino, substituted aziridino, benzylthio, substituted benzylthio, thiamorpholinosulfone, substituted thiamorpholinosulfone, benzylsulfinyl, substituted benzylsulfinyl, arylsulfinyl, substituted arylsulfinyl, benzylsulfonyl, substituted benzylsulfonyl, cyanoalkyl, halocyanoalkyl, haloalkanoate, dialkanoate, ketaolkyl, ketoalkanoate, benzylamino, substituted benzylamino, benzoxy, substituted benzoxy, phenoxy, substituted phenoxy, benzycyano, and substituted benzylcyano; R1 is hydrogen or mmethyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxy, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, subtituted cycloalkyl, aryl, substituted aryl, benzyl, and substituted benzyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.

Abstract translation: 涵盖红霉素A，B和C的磺酰基衍生物，其结构式如下：