公开(公告)号：US3189606A

公开(公告)日：1965-06-15

申请号：US29845963

申请日：1963-07-29

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  COLE JOHN WAYNE

IPC: C07J53/00 ,  C07J75/00

CPC classification number: C07J53/00 ,  C07J75/00

公开(公告)号：US3450725A

公开(公告)日：1969-06-17

申请号：US3450725D

申请日：1966-10-24

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN

IPC: C07J31/00 ,  C07J53/00 ,  C07J75/00 ,  C07C169/20 ,  C07C167/00 ,  C07C169/24

CPC classification number: C07J53/00 ,  C07J31/00 ,  C07J75/00

公开(公告)号：US3884903A

公开(公告)日：1975-05-20

申请号：US50441774

申请日：1974-09-09

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  MARTIN JERRY ROY ,  MCALPINE JAMES BRUCE ,  PAUVLIK JEANNE MARIE ,  TADANIER JOHN SOLOMAN

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: Covers a 4''''-deoxy-4''''-oxoerythromycin compounds and derivatives thereof which are useful as antibiotics having a formula selected from the group consisting of:

WHERE R is -CH2SR3, R2 is hydrogen or loweralkyl, R3 is loweralkyl, and R1 is hydrogen or loweralkanoyl;

WHERE R1 and R2 are as before defined;

WHERE R is hydrogen or CH3CO;

where R1 is hydrogen or RCO, R is loweralkyl, R2 is hydrogen, CH3CO or RCO where R is loweralkyl; and

WHERE R3 is hydrogen or RCO where R is loweralkyl.

Abstract translation: 包含4' - 脱氧-4'-氧代红霉素化合物及其衍生物，其可用作具有选自以下的式的抗生素：

公开(公告)号：US3869445A

公开(公告)日：1975-03-04

申请号：US42365273

申请日：1973-12-10

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN SOLOMAN ,  VONESCH ANNE MARY

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Covers sulfonyl derivatives of erythromycin A, B and C falling within the following structural formula:

WHERE R is selected from the group consisting of amino, monoalkyl amino, dialkyl amino, alkoxy, morpholino, substituted morpholino, piperazino, substituted piperazino, piperidino, substituted piperidino, alkylthio, alkylsulfonyl, arylthio, substituted arylthio, arylsulfonyl, substituted arylsulfonyl, thiamorpholino, aziridino, substituted aziridino, benzylthio, substituted benzylthio, thiamorpholinosulfone, substituted thiamorpholinosulfone, benzylsulfinyl, substituted benzylsulfinyl, arylsulfinyl, substituted arylsulfinyl, benzylsulfonyl, substituted benzylsulfonyl, cyanoalkyl, halocyanoalkyl, haloalkanoate, dialkanoate, ketaolkyl, ketoalkanoate, benzylamino, substituted benzylamino, benzoxy, substituted benzoxy, phenoxy, substituted phenoxy, benzycyano, and substituted benzylcyano; R1 is hydrogen or mmethyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxy, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, subtituted cycloalkyl, aryl, substituted aryl, benzyl, and substituted benzyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.

Abstract translation: 涵盖红霉素A，B和C的磺酰基衍生物，其结构式如下：