公开(公告)号：US3686187A

公开(公告)日：1972-08-22

申请号：US3686187D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： COLE JOHN WAYNE ,  HALLAS ROBERT

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A NEW SERIES OF PIPERDINE DERIVATIVES HAS BEEN DISCOVERED; THEY ARE COMPOUNDS CARRYING, IN THE 4-POSITION OF THE PIPERIDINE RING, A SUBSTITUTED ANILINO GROUP AND IN THE 1-POSITION, A P-FLUOROPHENYL RING SEPARATED FROM THE PIPERIDINE RING BY A CARBON CHAIN OF 4. THESE NEW COMPOUNDS AND THEIR NON-TOXIC ACID ADDITION SALTS ARE HIGHLY EFFECTIVE ANALGEICES OF LOW TOXICITY.

公开(公告)号：US3691176A

公开(公告)日：1972-09-12

申请号：US3691176D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  COLE JOHN WAYNE

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A new series of piperidine derivatives has been discovered; they are the N-(3-(p-fluorophenoxy)propyl)piperidines carrying in the 4-position of the piperidine ring a substituted anilino group. These new compounds and their non-toxic acid addition salts are highly effective analgesics of low toxicity.

公开(公告)号：US3884902A

公开(公告)日：1975-05-20

申请号：US35712473

申请日：1973-05-04

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  MARTIN JERRY ROY ,  SOLOMAN JOHN

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: Covers erythromycin sulfonyl derivatives which are useful as antibiotics when administered to warm blooded animals.

Abstract translation: 涵盖红霉素磺酰基衍生物，当向温血动物施用时可用作抗生素。

公开(公告)号：US3869445A

公开(公告)日：1975-03-04

申请号：US42365273

申请日：1973-12-10

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN SOLOMAN ,  VONESCH ANNE MARY

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Covers sulfonyl derivatives of erythromycin A, B and C falling within the following structural formula:

WHERE R is selected from the group consisting of amino, monoalkyl amino, dialkyl amino, alkoxy, morpholino, substituted morpholino, piperazino, substituted piperazino, piperidino, substituted piperidino, alkylthio, alkylsulfonyl, arylthio, substituted arylthio, arylsulfonyl, substituted arylsulfonyl, thiamorpholino, aziridino, substituted aziridino, benzylthio, substituted benzylthio, thiamorpholinosulfone, substituted thiamorpholinosulfone, benzylsulfinyl, substituted benzylsulfinyl, arylsulfinyl, substituted arylsulfinyl, benzylsulfonyl, substituted benzylsulfonyl, cyanoalkyl, halocyanoalkyl, haloalkanoate, dialkanoate, ketaolkyl, ketoalkanoate, benzylamino, substituted benzylamino, benzoxy, substituted benzoxy, phenoxy, substituted phenoxy, benzycyano, and substituted benzylcyano; R1 is hydrogen or mmethyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxy, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, subtituted cycloalkyl, aryl, substituted aryl, benzyl, and substituted benzyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.

Abstract translation: 涵盖红霉素A，B和C的磺酰基衍生物，其结构式如下：