公开(公告)号：US20240391860A1

公开(公告)日：2024-11-28

申请号：US18681328

申请日：2022-08-26

Applicant: API CORPORATION

Inventor： Hirotsugu TANIIKE ,  Shunsuke TSUJI ,  Masaki NAGAHAMA ,  Yurie KOBA

IPC: C07C51/367 ,  C07C51/47

Abstract: Salicylic acid is produced with high productivity by reacting 2-halogenated benzoic acid in an aqueous solvent at a reaction temperature of 155° C. or higher and 300° C. or lower in the presence of a copper source and a ligand. Preferably, the method further includes a purification step A in which the obtained salicylic acid is brought into contact with a styrene-based synthetic adsorbent and/or a purification step B in which the obtained salicylic acid is brought into contact with zeolite. The compound is led to raw materials for various pharmaceuticals or intermediates thereof (for example, acetylsalicylic acid).

公开(公告)号：US20250011278A1

公开(公告)日：2025-01-09

申请号：US18705667

申请日：2022-11-15

Applicant: API CORPORATION

Inventor： Yurie KOBA ,  Hirotsugu TANIIKE ,  Naoyuki WATANABE

IPC: C07C231/10 ,  B01J23/44 ,  B01J35/40 ,  B01J35/56 ,  B01J35/66 ,  C07C231/24

Abstract: A method for producing acetaminophen, the method comprising causing p-nitrophenol to undergo an acetamination reaction to produce the acetaminophen, by passing a solution containing the p-nitrophenol through a column packed with a catalyst while also passing an acetylating agent and hydrogen through the column. The catalyst is a supported metal catalyst in which a metal element is supported on a monolith porous body, and a reaction temperature of the acetamination reaction is 0° C. to 60° C., and a reaction pressure of the acetamination reaction is 0.1 MPa to 1 MPa.

公开(公告)号：US20230192596A1

公开(公告)日：2023-06-22

申请号：US17999152

申请日：2021-05-14

Applicant: API CORPORATION

Inventor： Masato MURAI ,  Hirotsugu TANIIKE ,  Yurie KOBA

IPC: C07C231/10 ,  B01J23/44 ,  B01J31/06 ,  B01J35/02 ,  B01J35/10 ,  B01J35/00

CPC classification number: C07C231/10 ,  B01J23/44 ,  B01J31/06 ,  B01J35/026 ,  B01J35/1038 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1019 ,  B01J35/1023 ,  B01J35/1028 ,  B01J35/1061 ,  B01J35/0066

Abstract: A method for producing acetaminophen may include causing p-nitrophenol to undergo an acetamination reaction to produce the acetaminophen, by passing a solution containing the p-nitrophenol through a column packed with a catalyst while also passing an acetylating agent and hydrogen through the column. The catalyst may be a supported metal catalyst in which a metal element is supported on a synthetic adsorbent, and a reaction temperature of the acetamination reaction is 0° C. to 60° C., and a reaction pressure of the acetamination reaction is 0.1 MPa to 1 MPa. With the method, it is possible to continuously produce acetaminophen safely and inexpensively with high selectivity and good yield, at a low reaction temperature and a low reaction pressure.