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    PROCESSES FOR PRODUCING PHARMACEUTICAL EXCIPIENTS FROM LIGNOCELLULOSIC BIOMASS, AND PHARMACEUTICAL EXCIPIENTS OBTAINED THEREFROM
    4.
    发明申请
    PROCESSES FOR PRODUCING PHARMACEUTICAL EXCIPIENTS FROM LIGNOCELLULOSIC BIOMASS, AND PHARMACEUTICAL EXCIPIENTS OBTAINED THEREFROM 审中-公开

    公开(公告)号：US20190298838A1

    公开(公告)日：2019-10-03

    申请号：US16272526

    申请日：2019-02-11

    Applicant: API Intellectual Property Holdings, LLC

    Inventor： Kimberly NELSON ,  Theodora RETSINA ,  Vesa PYLKKANEN

    IPC: A61K47/38 ,  C08H8/00 ,  C08B37/00 ,  C08H7/00

    Abstract: In some variations, the invention provides a process for producing a microcrystalline cellulose material, comprising: fractionating lignocellulosic biomass feedstock in the presence of an acid, a solvent for lignin, and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; chemically and/or mechanically treating the cellulose-rich solids to form microcrystalline cellulose having an average crystallinity of at least 60%; and recovering the microcrystalline cellulose as a pharmaceutical excipient. The pharmaceutical excipient may function as an antiadherent, a binder, a coating, or a disintegrant. In some embodiments, the pharmaceutical excipient further comprises a lignin-derived lubricant, glidant, sorbent, preservative, or other component. The pharmaceutical excipient may be present in a pill, tablet, capsule, powder, slurry, or other pharmaceutically effective and acceptable form.

    NANOCELLULOSE-POLYMER COMPOSITES, AND PROCESSES FOR PRODUCING THEM
    7.
    发明申请
    NANOCELLULOSE-POLYMER COMPOSITES, AND PROCESSES FOR PRODUCING THEM 审中-公开
    纳米纤维素聚合物复合材料及其生产工艺

    公开(公告)号：US20160168363A1

    公开(公告)日：2016-06-16

    申请号：US14750961

    申请日：2015-06-25

    Applicant: API Intellectual Property Holdings, LLC

    Inventor： Kimberly NELSON ,  Ryan P. O'CONNOR ,  Theodora RETSINA

    IPC: C08L1/04 ,  D21B1/02 ,  C08J3/00 ,  C12P19/02 ,  C12P7/10 ,  C08B15/08 ,  D21C5/00

    CPC classification number: C08L1/04 ,  B82Y30/00 ,  C08B15/08 ,  C08H8/00 ,  C08J3/005 ,  C08J2301/04 ,  C08J2400/12 ,  C08J2497/00 ,  C08L1/02 ,  C08L2205/03 ,  C12P7/10 ,  C12P7/40 ,  C12P19/02 ,  D21B1/021 ,  D21C5/00 ,  D21C9/007 ,  D21C11/0007 ,  D21H11/18 ,  Y02E50/16 ,  Y02P40/44 ,  C08L97/005 ,  C08L67/04

    Abstract: A polymer-nanocellulose-lignin composite as disclosed comprises a polymer, nanocellulose, and lignin, wherein lignin forms a hydrophobic interface between the polymer and the nanocellulose. In some variations, a process is disclosed for producing a polymer-nanocellulose-lignin composite material, comprising: fractionating lignocellulosic biomass in the presence of an acid, a solvent for lignin, and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin, wherein lignin deposits onto fiber surfaces or into fiber pores; mechanically treating the cellulose-rich solids to form a hydrophobic nanocellulose material comprising cellulose fibrils and/or cellulose crystals; hydrolyzing the hemicellulose to generate fermentable hemicellulosic sugars; fermenting the fermentable hemicellulosic sugars to generate a monomer or monomer precursor; polymerizing the monomer to produce a polymer; and combining the polymer with the lignin-coated nanocellulose to generate a polymer-nanocellulose-lignin composite material for use in a wide variety of products.

    Abstract translation: 所公开的聚合物 - 纳米纤维素 - 木质素复合材料包括聚合物，纳米纤维素和木质素，其中木质素在聚合物和纳米纤维素之间形成疏水界面。 在一些变型中，公开了一种用于生产聚合物 - 纳米纤维素 - 木质素复合材料的方法，其包括：在酸，木质素和水的溶剂存在下分解木质纤维素生物质，以产生富含纤维素的固体和含有半纤维素的液体 和木质素，其中木质素沉积到纤维表面或纤维孔中; 机械处理富含纤维素的固体以形成包含纤维素原纤维和/或纤维素晶体的疏水性纳米纤维素材料; 水解半纤维素以产生可发酵的半纤维素糖; 发酵可发酵的半纤维素糖以产生单体或单体前体; 聚合单体以产生聚合物; 并将聚合物与木质素包被的纳米纤维素组合以产生用于各种产品的聚合物 - 纳米纤维素 - 木质素复合材料。

    PRODUCTION OF SUGARS AND CO-PRODUCTS FROM CELLULOSIC WASTE STREAMS
    8.
    发明申请
    PRODUCTION OF SUGARS AND CO-PRODUCTS FROM CELLULOSIC WASTE STREAMS 审中-公开
    从蜂窝状废物流中生产糖和副产品

    公开(公告)号：US20140370551A1

    公开(公告)日：2014-12-18

    申请号：US14305076

    申请日：2014-06-16

    Applicant: API Intellectual Property Holdings, LLC

    Inventor： Theodora RETSINA ,  Kimberly NELSON

    IPC: C13K1/02 ,  C12P19/14 ,  C12P19/02

    CPC classification number: C13K1/02 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14

    Abstract: This disclosure provides a business method and system for generating sugars and recycling a non-biomass component from a waste stream. In some embodiments, a waste stream comprising cellulose and a non-biomass component is saccharified to produce glucose, followed by recovery of the glucose and non-biomass component, which may be recycled to another site associated with production of a cellulose-containing product that contains the non-biomass component. In certain scenarios, the waste stream is generated at a first location, cellulose pretreatment (if desired) and hydrolysis are conducted at a second location, and the non-biomass component is recycled to the first location or a third location. The non-biomass component may include metals, metal oxides, salts, organic compounds, inorganic compounds, oligomers, or polymers, for example.

    Abstract translation: 本公开提供了一种用于产生糖并从废物流再循环非生物量组分的商业方法和系统。 在一些实施方案中，包含纤维素和非生物量组分的废物流被糖化以产生葡萄糖，然后回收葡萄糖和非生物量组分，其可以再循环到与生产含纤维素的产品相关的另一位点， 含有非生物量成分。 在某些情况下，在第一位置处产生废物流，在第二位置进行纤维素预处理（如果需要）和水解，并且将非生物质成分再循环到第一位置或第三位置。 非生物质成分可以包括例如金属，金属氧化物，盐，有机化合物，无机化合物，低聚物或聚合物。

    PROCESSES AND APPARATUS FOR PRODUCING FURFURAL, LEVULINIC ACID, AND OTHER SUGAR-DERIVED PRODUCTS FROM BIOMASS
    9.
    发明申请
    PROCESSES AND APPARATUS FOR PRODUCING FURFURAL, LEVULINIC ACID, AND OTHER SUGAR-DERIVED PRODUCTS FROM BIOMASS 审中-公开
    用于从生物量生产糠醛，橄榄酸和其他衍生产品的方法和装置

    公开(公告)号：US20140186903A1

    公开(公告)日：2014-07-03

    申请号：US14083115

    申请日：2013-11-18

    Applicant: API Intellectual Property Holdings, LLC

    Inventor： Theodora RETSINA ,  Vesa PYLKKANEN ,  Kimberly NELSON ,  Ryan O'CONNOR

    IPC: C07C51/09 ,  C12P17/04 ,  C07D307/50 ,  C12P7/40

    CPC classification number: C07D307/50 ,  C07C51/09 ,  C07C51/16 ,  C12P7/40 ,  C12P17/04 ,  Y02E50/16 ,  C07C59/76 ,  C07C53/02

    Abstract: In some variations, the invention provides a process for producing furfural, 5-hydroxymethylfurfural, and/or levulinic acid from cellulosic biomass, comprising: fractionating the feedstock in the presence of a solvent for lignin, sulfur dioxide, and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose contained in the liquor, to produce hemicellulosic monomers; dehydrating the hemicellulose to convert at least a portion of C5 hemicelluloses to furfural and to convert at least a portion of C6 hemicelluloses to 5-hydroxymethylfurfural; converting at least some of the 5-hydroxymethylfurfural to levulinic acid and formic acid; and recovering at least one of the furfural, the 5-hydroxymethylfurfural, or the levulinic acid. Other embodiments provide a process for dehydrating hemicellulose to convert oligomeric C5 hemicelluloses to furfural and to convert oligomeric C6 hemicelluloses to 5-hydroxymethylfurfural. The furfural may be converted to succinic acid, or to levulinic acid, for example.

    Abstract translation: 在一些变型中，本发明提供了一种从纤维素生物质产生糠醛，5-羟甲基糠醛和/或乙酰丙酸的方法，包括：在木素，二氧化硫和水的溶剂存在下，将原料分馏，以产生液体 含有半纤维素，富含纤维素的固体和木质素; 水解液体中所含的半纤维素，以产生半纤维素单体; 使半纤维素脱水以将至少一部分C5半纤维素转化为糠醛并将至少一部分C6半纤维素转化为5-羟甲基糠醛; 将至少一些5-羟甲基糠醛转化成乙酰丙酸和甲酸; 并回收至少一种糠醛，5-羟甲基糠醛或乙酰丙酸。 其它实施方案提供了使半纤维素脱水以将低聚C5半纤维素转化为糠醛并将低聚C6半纤维素转化为5-羟甲基糠醛的方法。 例如，糠醛可以转化为琥珀酸或乙酰丙酸。

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