公开(公告)号：US11940757B2

公开(公告)日：2024-03-26

申请号：US17353943

申请日：2021-06-22

Applicant: Accelerate Diagnostics, Inc.

Inventor： Oleg Gusyatin

IPC: G03H1/10 ,  C12M1/34 ,  G01N15/02 ,  G01N15/0227 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1434 ,  G01N23/20 ,  G02B21/00 ,  G02B21/36 ,  G03H1/00 ,  G03H1/04 ,  G03H1/08 ,  G03H1/26

CPC classification number: G03H1/10 ,  C12M41/36 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1475 ,  G01N23/20 ,  G02B21/0008 ,  G02B21/365 ,  G03H1/0443 ,  G01N2015/0233 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2015/1493 ,  G01N2015/1497 ,  G03H2001/0033 ,  G03H2001/0447 ,  G03H1/0866 ,  G03H2001/2655 ,  G03H2222/13 ,  G03H2222/52 ,  G03H2226/13 ,  G03H2227/03

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

公开(公告)号：US20240385099A1

公开(公告)日：2024-11-21

申请号：US18692433

申请日：2022-09-15

Applicant: Accelerate Diagnostics, Inc.

Inventor： Landon Prisbey ,  Steven W. Metzger ,  Oleg Gusyatin

IPC: G01N15/0227 ,  C12Q1/04 ,  C12Q1/18 ,  G01N15/02 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1433 ,  G01N15/1434

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

公开(公告)号：US10669566B2

公开(公告)日：2020-06-02

申请号：US16007071

申请日：2018-06-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt ,  Phillip C. Halbert ,  Solene Bourgeois

IPC: C12Q1/02 ,  G02B7/28 ,  G01N15/06 ,  G01N21/64 ,  B01L3/00 ,  C12Q1/04 ,  G01N1/38 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G01N35/04 ,  G01N35/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US10253355B2

公开(公告)日：2019-04-09

申请号：US15283922

申请日：2016-10-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: C12Q1/6841 ,  C12Q1/02 ,  G02B7/28 ,  G01N21/64 ,  G01N35/02 ,  H04N5/232 ,  G01N35/00 ,  C12M1/34 ,  G01N35/10 ,  B01L3/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.

公开(公告)号：US20220011722A1

公开(公告)日：2022-01-13

申请号：US17353943

申请日：2021-06-22

Applicant: Accelerate Diagnostics, Inc.

Inventor： Oleg Gusyatin

IPC: G03H1/10 ,  G03H1/04 ,  G02B21/00 ,  G02B21/36 ,  G01N23/20 ,  C12M1/34 ,  G01N15/14 ,  G01N15/02

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

公开(公告)号：US11079719B2

公开(公告)日：2021-08-03

申请号：US16028287

申请日：2018-07-05

Applicant: Accelerate Diagnostics, Inc.

Inventor： Oleg Gusyatin

IPC: G03H1/10 ,  G03H1/04 ,  G02B21/00 ,  G02B21/36 ,  G01N23/20 ,  C12M1/34 ,  G01N15/14 ,  G01N15/02 ,  G03H1/08 ,  G03H1/00 ,  G03H1/26 ,  G01N15/10

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

公开(公告)号：US20180291419A1

公开(公告)日：2018-10-11

申请号：US16007071

申请日：2018-06-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt ,  Phillip C. Halbert ,  Solene Bourgeois

IPC: C12Q1/02 ,  G02B7/28 ,  C12Q1/04 ,  G01N1/38 ,  G01N15/06 ,  B01L3/00 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G01N21/64 ,  G01N35/00 ,  G01N35/04

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US10023895B2

公开(公告)日：2018-07-17

申请号：US15085953

申请日：2016-03-30

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: C12Q1/18 ,  C12Q1/02 ,  B01L3/00 ,  C12Q1/04 ,  G01N1/38 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G02B7/28 ,  G01N15/06 ,  G01N21/64 ,  G01N35/04 ,  G01N35/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US20220066390A1

公开(公告)日：2022-03-03

申请号：US17474005

申请日：2021-09-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： Oleg Gusyatin

IPC: G03H1/10 ,  G03H1/04 ,  G02B21/00 ,  G02B21/36 ,  G01N23/20 ,  C12M1/34 ,  G01N15/14 ,  G01N15/02

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

公开(公告)号：US20170023599A1

公开(公告)日：2017-01-26

申请号：US15283922

申请日：2016-10-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: G01N35/00 ,  C12Q1/68

CPC classification number: C12Q1/6841 ,  B01L3/545 ,  C12Q1/025 ,  G01N21/6458 ,  G01N35/00069 ,  G01N35/025 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2035/00158 ,  G01N2035/00346 ,  G01N2035/1032 ,  G02B7/28

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.

Abstract translation: 公开了一种用于自动化微生物鉴定和抗生素敏感性测试的系统，其包括试剂盒，试剂台，盒式磁带，载物台，移液器组件，光学检测系统和控制器。 该系统旨在动态调整电机怠速转矩以控制热负荷，并采用快速聚焦过程来确定单个微生物的真实聚焦位置。 该系统还可以使用动态稀释来量化样品中活的微生物的相对丰度，并促进微生物在定制培养基中的生长以用于快速，准确的抗微生物敏感性测试。 还公开了自动质量控制测试组件及其使用方法。