公开(公告)号：US10254204B2

公开(公告)日：2019-04-09

申请号：US15586132

申请日：2017-05-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： Landon Prisbrey ,  Elise Blackmore ,  Kenneth R. Hance ,  Steven W. Metzger ,  Kevin Marshall

IPC: A61K39/12 ,  G01N1/40 ,  B03C5/00 ,  C12N13/00 ,  G01N33/49 ,  C12M1/00 ,  C12Q1/02 ,  C12Q1/24 ,  G01N1/34 ,  G02B21/36 ,  C12N7/00

Abstract: Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface. In some examples, a biological sample containing contaminants and one or more microbial cells is introduced to a well disposed in a porous filter medium, wherein the porous filter medium includes pores smaller than the one or more microbial cells, thereby preventing the one or more microbial cells from entering the porous filter medium.

公开(公告)号：USD799056S1

公开(公告)日：2017-10-03

申请号：US29583756

申请日：2016-11-08

Applicant: Accelerate Diagnostics, Inc.

Designer： Solene Bourgeois ,  Phillip C. Halbert ,  Kyle A. Koning ,  Kevin Marshall ,  Austin Ashby ,  Matthew Ketterer ,  Josh Harrison

公开(公告)号：USD773685S1

公开(公告)日：2016-12-06

申请号：US29525007

申请日：2015-04-24

Applicant: ACCELERATE DIAGNOSTICS, INC.

Designer： Solene Bourgeois ,  Phillip C. Halbert ,  Kyle A. Koning ,  Kevin Marshall ,  Austin Ashby ,  Matthew Ketterer ,  Josh Harrison

公开(公告)号：US20210008541A1

公开(公告)日：2021-01-14

申请号：US16908516

申请日：2020-06-22

Applicant: Accelerate Diagnostics, Inc.

Inventor： Kevin Marshall ,  Austin Ashby ,  Josh Harrison ,  Steven W. Metzger ,  Wayne Showalter ,  Erik Molina ,  Jamie Roberson

IPC: B01L3/02

Abstract: Systems and methods for automated biological sample preparation for use in rapid identification and antimicrobial susceptibility testing of microorganisms, such as bacteria and fungi, are provided.

公开(公告)号：US10669566B2

公开(公告)日：2020-06-02

申请号：US16007071

申请日：2018-06-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt ,  Phillip C. Halbert ,  Solene Bourgeois

IPC: C12Q1/02 ,  G02B7/28 ,  G01N15/06 ,  G01N21/64 ,  B01L3/00 ,  C12Q1/04 ,  G01N1/38 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G01N35/04 ,  G01N35/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US10253355B2

公开(公告)日：2019-04-09

申请号：US15283922

申请日：2016-10-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: C12Q1/6841 ,  C12Q1/02 ,  G02B7/28 ,  G01N21/64 ,  G01N35/02 ,  H04N5/232 ,  G01N35/00 ,  C12M1/34 ,  G01N35/10 ,  B01L3/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.

公开(公告)号：US20180291419A1

公开(公告)日：2018-10-11

申请号：US16007071

申请日：2018-06-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt ,  Phillip C. Halbert ,  Solene Bourgeois

IPC: C12Q1/02 ,  G02B7/28 ,  C12Q1/04 ,  G01N1/38 ,  G01N15/06 ,  B01L3/00 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G01N21/64 ,  G01N35/00 ,  G01N35/04

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US10023895B2

公开(公告)日：2018-07-17

申请号：US15085953

申请日：2016-03-30

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: C12Q1/18 ,  C12Q1/02 ,  B01L3/00 ,  C12Q1/04 ,  G01N1/38 ,  G01N35/02 ,  G01N35/10 ,  H04N5/232 ,  G02B7/28 ,  G01N15/06 ,  G01N21/64 ,  G01N35/04 ,  G01N35/00

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

公开(公告)号：US20170234781A1

公开(公告)日：2017-08-17

申请号：US15586132

申请日：2017-05-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： Landon Prisbrey ,  Elise Blackmore ,  Kenneth R. Hance ,  Steven W. Metzger ,  Kevin Marshall

IPC: G01N1/40 ,  C12N13/00 ,  B03C5/00

CPC classification number: G01N1/40 ,  B03C5/005 ,  B03C2201/26 ,  C12M47/12 ,  C12N7/00 ,  C12N13/00 ,  C12N2710/00051 ,  C12Q1/02 ,  C12Q1/24 ,  G01N1/34 ,  G01N33/491 ,  G01N2001/4038 ,  G02B21/367

Abstract: Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface. In some examples, a biological sample containing contaminants and one or more microbial cells is introduced to a well disposed in a porous filter medium, wherein the porous filter medium includes pores smaller than the one or more microbial cells, thereby preventing the one or more microbial cells from entering the porous filter medium.

公开(公告)号：US20170023599A1

公开(公告)日：2017-01-26

申请号：US15283922

申请日：2016-10-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: G01N35/00 ,  C12Q1/68

CPC classification number: C12Q1/6841 ,  B01L3/545 ,  C12Q1/025 ,  G01N21/6458 ,  G01N35/00069 ,  G01N35/025 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2035/00158 ,  G01N2035/00346 ,  G01N2035/1032 ,  G02B7/28

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.

Abstract translation: 公开了一种用于自动化微生物鉴定和抗生素敏感性测试的系统，其包括试剂盒，试剂台，盒式磁带，载物台，移液器组件，光学检测系统和控制器。 该系统旨在动态调整电机怠速转矩以控制热负荷，并采用快速聚焦过程来确定单个微生物的真实聚焦位置。 该系统还可以使用动态稀释来量化样品中活的微生物的相对丰度，并促进微生物在定制培养基中的生长以用于快速，准确的抗微生物敏感性测试。 还公开了自动质量控制测试组件及其使用方法。