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公开(公告)号：US20200277296A1
公开(公告)日：2020-09-03
申请号：US16758892
申请日：2018-10-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael E. Mertzman , Carolyn Diane Dzierba , Jason M. Guernon , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Jianliang Shi , Steven H. Spergel
IPC: C07D487/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US09675571B2
公开(公告)日：2017-06-13
申请号：US14776035
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Steven P. Seitz , Amy C. Hart , Jay A. Markwalder
IPC: A61K31/135 , A61K31/196 , C07C255/44 , C07C255/57 , C07D213/84 , C07C275/42 , C07D317/66 , C07C311/51 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07C233/55 , C07D261/14 , C07C235/38 , C07D271/12 , C07D213/56 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07C69/743 , C07C271/28 , C07C311/47 , C07D213/75
CPC classification number: A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US12172975B2
公开(公告)日：2024-12-24
申请号：US17274220
申请日：2019-09-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Jie Chen , Carolyn Diane Dzierba , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Sing-Yuen Sit
IPC: C07D401/04 , C07D401/14 , C07D405/14
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US20220119388A1
公开(公告)日：2022-04-21
申请号：US17503516
申请日：2021-10-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael C. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US20210309633A1
公开(公告)日：2021-10-07
申请号：US17274227
申请日：2019-09-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Carolyn Diane Dzierba , Amy C. Hart , John E. Macor , William J. Pitts
IPC: C07D401/04 , C07D403/04 , C07D413/04 , C07D401/14 , C07D413/14
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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Patent Agency Ranking
公开(公告)号：US20190389859A1
公开(公告)日：2019-12-26
申请号：US16484604
申请日：2018-02-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).
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公开(公告)号：US09765018B2
公开(公告)日：2017-09-19
申请号：US14897668
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , David K. Williams , Amy C. Hart , Jennifer Inghrim
IPC: C07C275/42 , C07C311/51 , C07D213/75 , C07D257/04 , C07D401/04 , A61K31/18 , A61K31/41 , A61K31/44 , C07D213/79 , C07D307/86 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07D307/79
CPC classification number: C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160137595A1
公开(公告)日：2016-05-19
申请号：US14897668
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , David K. William , Amy C. Hart , Jennifer Inghrim
IPC: C07C275/42 , C07D213/79 , C07D257/04 , C07C311/51 , C07C311/09 , C07D307/79 , A61K45/06 , A61K31/196 , A61K31/4418 , A61K31/444 , A61K31/41 , A61K31/18 , A61K31/343 , A61K31/277 , C07D213/75
CPC classification number: C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-二加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或 使用本发明化合物的炎症性疾病。
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公开(公告)号：US20240425505A1
公开(公告)日：2024-12-26
申请号：US18817352
申请日：2024-08-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US12157733B2
公开(公告)日：2024-12-03
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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