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公开(公告)号：US11767322B2
公开(公告)日：2023-09-26
申请号：US17503516
申请日：2021-10-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael C. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
公开(公告)号：US20220315580A1
公开(公告)日：2022-10-06
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US20200347071A1
公开(公告)日：2020-11-05
申请号：US16963886
申请日：2019-01-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Carolyn Diane Dzierba , Hua Gong , Jason M. Guernon , Junqing Guo , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Jianliang Shi , Brian Lee Venables , Carolyn A. Weigelt , Yong-Jin Wu , Zhizhen Barbara Zheng , Sing-Yuen Sit , Jie Chen
IPC: C07D487/04
Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.
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公开(公告)号：US20190117638A1
公开(公告)日：2019-04-25
申请号：US16225850
申请日：2018-12-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC: A61K31/454 , C07D403/04 , C07D401/04
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20180000807A1
公开(公告)日：2018-01-04
申请号：US15706172
申请日：2017-09-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC: A61K31/454 , C07D403/04 , C07D401/04
CPC classification number: A61K31/454 , C07D401/04 , C07D403/04
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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Patent Agency Ranking
公开(公告)号：US09221796B2
公开(公告)日：2015-12-29
申请号：US14589205
申请日：2015-01-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC: C07D403/04 , C07D401/04
CPC classification number: A61K31/454 , C07D401/04 , C07D403/04
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是NR2B受体的配体，可用于治疗中枢神经系统的各种疾病。
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公开(公告)号：US20150191452A1
公开(公告)日：2015-07-09
申请号：US14589205
申请日：2015-01-05
Applicant: Bristol-Myers Squibb Company
Inventor： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC: C07D403/04 , C07D401/04
CPC classification number: A61K31/454 , C07D401/04 , C07D403/04
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是NR2B受体的配体，可用于治疗中枢神经系统的各种疾病。
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公开(公告)号：US20250074909A1
公开(公告)日：2025-03-06
申请号：US18928275
申请日：2024-10-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US12110290B2
公开(公告)日：2024-10-08
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
公开(公告)号：US20240109888A1
公开(公告)日：2024-04-04
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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