公开(公告)号：US11287423B2

公开(公告)日：2022-03-29

申请号：US16594843

申请日：2019-10-07

Applicant: Biogen MA Inc.

Inventor： Leonid Gorelik ,  Kenneth J. Simon ,  Meena Subramanyam ,  Mia Marie Rushe

IPC: G01N33/543

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

公开(公告)号：US20160187337A1

公开(公告)日：2016-06-30

申请号：US15063777

申请日：2016-03-08

Applicant: Biogen MA Inc.

Inventor： Leonid Gorelik ,  Kenneth J. Simon ,  Meena Subramanyam ,  Mia Marie Rushe

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/025 ,  G01N2469/20 ,  G01N2800/50

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

Abstract translation: 本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。 公开了一种方法，其包括从适合于JCV抗体结合的条件下获得来自受试者（例如血浆，血清，血液，尿液或脑脊液）的生物样品，使样品与高度纯化的病毒样颗粒HPVLP接触） 在样品中检测HPVLP，并检测样品中JCV抗体与HPVLP结合的水平。在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。

公开(公告)号：US10444234B2

公开(公告)日：2019-10-15

申请号：US15063777

申请日：2016-03-08

Applicant: Biogen MA Inc.

Inventor： Leonid Gorelik ,  Kenneth J. Simon ,  Meena Subramanyam ,  Mia Marie Rushe

IPC: C12Q1/70 ,  G01N33/569

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

公开(公告)号：US20160151390A1

公开(公告)日：2016-06-02

申请号：US14957745

申请日：2015-12-03

Applicant: Biogen MA Inc.

Inventor： Leonid Gorelik ,  Margot Brickelmaier ,  Alexey Lugovskoy

IPC: A61K31/575 ,  C07K16/28 ,  A61K39/395

CPC classification number: A61K31/575 ,  A61K31/196 ,  A61K31/352 ,  A61K31/437 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/554 ,  A61K31/573 ,  A61K31/58 ,  A61K31/69 ,  A61K31/7048 ,  A61K38/12 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/38 ,  C07K16/2839 ,  Y02A50/467 ,  A61K2300/00

Abstract: The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are useful to prevent or treat DNA virus associated conditions (e.g., PML) in subjects that are immuno-compromised. Compositions are provided that inhibit intracellular replication of DNA viruses.

Abstract translation: 本发明涉及用于治疗受DNA病毒（例如JC病毒或BK病毒）感染或有感染风险的受试者的组合物，方法和试剂盒。 本发明的方面可用于预防或治疗免疫缺陷受试者中的DNA病毒相关病症（例如，PML）。 提供了抑制细胞内DNA病毒复制的组合物。

公开(公告)号：US10955422B2

公开(公告)日：2021-03-23

申请号：US15120573

申请日：2015-02-27

Applicant: Biogen MA Inc.

Inventor： Tatiana Plavina ,  John P. Carulli ,  Leonid Gorelik ,  Teresa Compton

IPC: G01N33/53 ,  G01N33/68 ,  C12Q1/6883

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive Multifocal Leukoencephalopathy (PML).

公开(公告)号：US20170016919A1

公开(公告)日：2017-01-19

申请号：US15120573

申请日：2015-02-27

Applicant: Biogen MA Inc.

Inventor： Tatiana Plavina ,  John P. Carulli ,  Leonid Gorelik ,  Teresa Compton

IPC: G01N33/68 ,  C12Q1/68

CPC classification number: G01N33/6896 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/025 ,  G01N2800/28 ,  G01N2800/50

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive Multifocal Leukoencephalopathy (PML).

Abstract translation: 本发明涉及评估患者进展性多灶性脑白质病（PML）风险的方法。