公开(公告)号：US20230149000A1

公开(公告)日：2023-05-18

申请号：US17995865

申请日：2021-04-09

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. MILNER ,  Jason B. KING ,  Nitesh KATTA ,  James W. TUNNELL

IPC: A61B10/02 ,  A61B18/22

CPC classification number: A61B10/02 ,  A61B18/22 ,  A61B2018/2266 ,  A61B2018/2205 ,  A61B2018/00761

Abstract: Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue.

公开(公告)号：US20160146730A1

公开(公告)日：2016-05-26

申请号：US14939044

申请日：2015-11-12

Applicant: Board of Regents, the University of Texas System

Inventor： James W. TUNNELL

IPC: G01N21/47 ,  G01N21/64 ,  G01N21/65 ,  G01J3/42

CPC classification number: G01N21/474 ,  A61B5/0075 ,  A61B5/444 ,  G01J3/42 ,  G01N21/31 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/1736 ,  G01N2021/174 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/06146 ,  G01N2201/0833

Abstract: Systems comprising an optical fiber switch connected to a light source and an optical fiber probe, the optical fiber probe comprising a first optical fiber connected to the optical fiber switch and a second optical fiber connected to a spectrophotometer. Methods for determining one or more tissue parameters comprising: emitting light from a first optical fiber into a tissue; collecting the light reemitted from the tissue with a second optical fiber; generating a spectra of the light reemitted from the tissue with a spectrophotometer; and utilizing a look-up table based algorithm to determine one or more tissue parameters, wherein the lookup-table based algorithm comprises the steps of: generating a look-up table by measuring the functional form of a reflectance measured by the spectrophotometer using one or more calibration standards with known optical properties; and implementing an iterative fitting routine based on the lookup-table.

Abstract translation: 包括连接到光源的光纤开关和光纤探针的系统，所述光纤探针包括连接到光纤开关的第一光纤和连接到分光光度计的第二光纤。 用于确定一个或多个组织参数的方法，包括：将光从第一光纤发射到组织中; 用第二光纤收集从组织再发射的光; 用分光光度计产生从组织再发射的光的光谱; 以及利用基于查找表的算法来确定一个或多个组织参数，其中所述基于查找表的算法包括以下步骤：通过测量由所述分光光度计测量的反射率的函数形式来生成查找表，使用一个或多个 具有已知光学性能的更多校准标准; 并且基于查找表来实现迭代拟合例程。