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1.发明申请MULTIPLEX LABELING OF MOLECULES BY SEQUENTIAL HYBRIDIZATION BARCODING USING PROBES WITH CLEAVABLE LINKERS 审中-公开通过使用具有可清除链接的探针进行序列杂交化修饰分子的多重标记公开(公告)号：US20160369329A1
公开(公告)日：2016-12-22
申请号：US15225820
申请日：2016-08-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Long CAI , Chee Huat Eng , Eric Lubeck
CPC classification number: C12Q1/6841 , C12Q2537/143 , C12Q2563/107
Abstract: The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci. In some embodiments, nucleic acid probes include a signal moiety connected with a binding sequence via a cleavable linker.
Abstract translation: 本发明尤其提供了用于在细胞，组织，器官或生物体中检测和/或定量核酸的技术。 通过顺序条码，本发明提供了用于大量目标（例如转录物和/或DNA基因座）的高通量分析的方法。 在一些实施方案中，核酸探针包括通过可切割接头与结合序列连接的信号部分。
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