公开(公告)号：US20170107160A1

公开(公告)日：2017-04-20

申请号：US15298172

申请日：2016-10-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dianne K. NEWMAN ,  Gargi KULKARNI ,  Brittany Jo BELIN

IPC: C05F11/08 ,  C12N1/20 ,  G01N33/92

CPC classification number: C05F11/08 ,  A01N63/00 ,  C12N1/14 ,  C12N1/20 ,  C12N15/52 ,  C12N15/82 ,  C12Y402/01084

Abstract: Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with hopanoid-producing nitrogen-fixing bacteria can be used as biofertilizer to stimulate plant growth and yield with enhanced tolerance to diverse stresses found in plant-microbe symbiotic microenvironments.

公开(公告)号：US20170275597A1

公开(公告)日：2017-09-28

申请号：US15466839

申请日：2017-03-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dianne K. NEWMAN ,  Kyle C. COSTA

IPC: C12N9/06 ,  A61K45/06 ,  C12Q1/26 ,  A61K38/44

CPC classification number: C12N9/0032 ,  A61K38/44 ,  A61K45/06 ,  C12Q1/26 ,  C12Y105/03 ,  G01N2500/04 ,  G01N2500/10

Abstract: Provided herein are phenazine degrading agents, methods and systems for interfering with viability of bacteria and related antimicrobial and compositions.

公开(公告)号：US20170283763A1

公开(公告)日：2017-10-05

申请号：US15420022

申请日：2017-01-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dianne K. NEWMAN ,  Ryan C. HUNTER

IPC: C12N1/20 ,  C12N1/36

Abstract: Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.

公开(公告)号：US20250058002A1

公开(公告)日：2025-02-20

申请号：US18646571

申请日：2024-04-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  NAVAL RESEARCH LABORATORY

Inventor： Dianne K. NEWMAN ,  Leonard TENDER

IPC: A61L2/03 ,  A61K31/7036 ,  A61N1/04 ,  A61P31/04

Abstract: Provided herein are methods and systems and related devices and compositions for electrochemical control of viability of redox active bacteria. The electrochemical control is performed by applying to a working electrode contacting a medium known or suspected to comprise the redox active bacteria, a reducing potential which is lower of the midpoint potential of a redox active compound produced by the redox active bacteria.

公开(公告)号：US20240141326A1

公开(公告)日：2024-05-02

申请号：US18278586

申请日：2022-02-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Daniel DAR ,  Dianne K. NEWMAN ,  Kirsten FRIEDA ,  Long CAI

IPC: C12N15/10

CPC classification number: C12N15/1065 ,  C12N15/1055 ,  C12N15/1058

Abstract: Method for detecting and barcoding the molecular changes occurring in two or more samples upon exposure to different stimuli. This disclosure herein sets for methods that allow a targeted transcriptome-imaging approach that records both gene-expression and spatial context within microscale assemblies at a single-cell and molecule resolution on biological samples. This disclosure herein sets for methods that allows the application to a variety of biological samples for the study of cellular processes, growth, and interactions between biological samples.

公开(公告)号：US20160058843A1

公开(公告)日：2016-03-03

申请号：US14830673

申请日：2015-08-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Dianne K. NEWMAN ,  Ryan C. HUNTER ,  George A. O'TOOLE

IPC: A61K38/38 ,  A61K31/53 ,  A01N43/707 ,  A01N37/18

CPC classification number: A61K38/38 ,  A01N37/18 ,  A01N43/707 ,  A61K31/53 ,  C12N1/20 ,  C12N1/36

Abstract: Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.

公开(公告)号：US20210322462A1

公开(公告)日：2021-10-21

申请号：US17234656

申请日：2021-04-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dianne K. NEWMAN ,  Melanie A. SPERO ,  Manuela MARTINS-GREEN ,  John D. COATES

IPC: A61K33/00 ,  A61K31/43 ,  A61K31/424 ,  A61K31/7056 ,  A61K31/545 ,  A61K31/496 ,  A61K31/4164 ,  A61K31/7036 ,  A61K31/431 ,  A61K31/546 ,  A61K31/427 ,  A61K33/14 ,  A61K33/18 ,  A61K38/48 ,  A61K38/18 ,  A61K31/355 ,  A61K31/198 ,  A61K9/06 ,  A61K9/00 ,  A61P31/02 ,  A61P17/02

Abstract: Wound healing matrices, compounds, compositions, methods and systems comprising one or more chlorates, one or more chlorites, one or more antibiotics, one or more other antimicrobials, and/or one or more wound healing agents.

公开(公告)号：US20210032603A1

公开(公告)日：2021-02-04

申请号：US17027587

申请日：2020-09-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dianne K. NEWMAN ,  Kyle C. COSTA

IPC: C12N9/06 ,  A61K38/44 ,  A61K45/06 ,  C12Q1/26

Abstract: Provided herein are phenazine degrading agents, methods and systems for interfering with viability of bacteria and related antimicrobial and compositions.

公开(公告)号：US20190142864A1

公开(公告)日：2019-05-16

申请号：US16157885

申请日：2018-10-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dianne K. NEWMAN ,  John COATES ,  Melanie A. SPERO

IPC: A61K33/20 ,  A61P31/04 ,  A61K31/7036

Abstract: Provided herein are methods, systems, and related compounds and compositions suitable for reducing antibiotic resistance and/or the survivability of Nar (cytoplasmic nitrate reductase)-and/or Nap (periplasmic nitrate reductase)-containing bacteria.

公开(公告)号：US20190119178A1

公开(公告)日：2019-04-25

申请号：US16155719

申请日：2018-10-09

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dianne K. NEWMAN ,  Gargi Kulkarni ,  Brittany Jo. Belin ,  Eric Giraud ,  Antonio Molinaro ,  Alba Silipo

IPC: C05F11/08 ,  C12N1/20

CPC classification number: C05F11/08 ,  A01N63/00 ,  C12N1/14 ,  C12N1/20 ,  C12N15/52 ,  C12N15/82 ,  C12Y402/01084

Abstract: Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with hopanoid-producing nitrogen-fixing bacteria can be used as biofertilizer to stimulate plant growth and yield with enhanced tolerance to diverse stresses found in plant-microbe symbiotic microenvironments.