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公开(公告)号：US10274715B2
公开(公告)日：2019-04-30
申请号：US14812874
申请日：2015-07-29
Applicant: CELLOMICS, INC.
Inventor： Ronald Albert Kuhn , Kim Anthony Ippolito , Dirk John Vandenberg, III
Abstract: Accurate, reliable, and robust laser-based autofocus solutions are presented for through-the-lens microscope applications using slides or micro-titer plates. The laser-based autofocus solutions solve many of the problems that have arisen due to multiple reflective surfaces at varying distances relative to a sample of interest. The laser-based autofocus solutions provide a unique solution to resolve the ambiguity caused by these multiple reflective surfaces by using an image-based approach.
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公开(公告)号：US20150260938A1
公开(公告)日：2015-09-17
申请号：US14728685
申请日：2015-06-02
Applicant: CELLOMICS, INC.
Inventor： Dirk John Vandenberg, III , Keith R. Heffley
CPC classification number: G02B7/003 , G02B21/00 , G02B26/008 , Y10T29/49817 , Y10T29/49826
Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies.
Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。
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公开(公告)号：US09400365B2
公开(公告)日：2016-07-26
申请号：US14728685
申请日：2015-06-02
Applicant: CELLOMICS, INC.
Inventor： Dirk John Vandenberg, III , Keith R. Heffley
CPC classification number: G02B7/003 , G02B21/00 , G02B26/008 , Y10T29/49817 , Y10T29/49826
Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies.
Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。
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Patent Agency Ranking
公开(公告)号：US09128046B2
公开(公告)日：2015-09-08
申请号：US13658263
申请日：2012-10-23
Applicant: Cellomics, Inc.
Inventor： Brent A. Samson , Chandrasekaran Vasudevan , Keith R. Heffley , Joseph M. Zock , Dirk John Vandenberg, III
IPC: G01N27/447 , B01L3/00 , B01L9/00 , G01N27/453
CPC classification number: G01N27/44756 , B01L3/50 , B01L3/5085 , B01L3/50853 , B01L9/00 , G01N27/453
Abstract: A slide holder assembly and method for use in high content screening of a comet assay. The slide holder assembly has an inside surface and is configured to receive a slide holding a plurality of biological cells on a top surface thereof. When the slide is secured within the slide holder assembly, the inside surface of the slide holder assembly and the top surface of the slide combine to form a cavity having an open top end. The cavity is watertight and configured to hold a liquid therein. A method of performing a comet assay using a slide disposed within a slide holder assembly. The method includes performing encapsulation, lysis, electrophoresis, staining, and imaging of cells on the slide while the slide remains secured within the slide holder assembly.
Abstract translation: 用于彗星测定的高含量筛选的载片架组件和方法。 滑动支架组件具有内表面，并且构造成容纳在其顶表面上容纳多个生物细胞的载片。 当滑块固定在滑块保持器组件内时，滑块保持器组件的内表面和滑块的顶表面组合形成具有开放顶端的空腔。 空腔是水密的并且构造成在其中保持液体。 使用设置在载玻片保持器组件内的滑块进行彗星测定的方法。 该方法包括在载玻片保持固定在载玻片保持器组件内时，在载玻片上进行细胞的包封，裂解，电泳，染色和成像。
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公开(公告)号：US20140192404A1
公开(公告)日：2014-07-10
申请号：US13734748
申请日：2013-01-04
Applicant: CELLOMICS, INC.
Inventor： Dirk John Vandenberg, III , Keith R. Heffley
CPC classification number: G02B7/003 , G02B21/00 , G02B26/008 , Y10T29/49817 , Y10T29/49826
Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies. Methods of aligning apertures of optical assemblies with viewing openings of a filter wheel or an optical assembly receiver and securing the optical assemblies to the filter wheel or the optical assembly receiver using a magnetic force.
Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。 将光学组件的孔径与滤光轮或光学组件接收器的观察孔对准的方法，并使用磁力将光学组件固定到滤光轮或光学组件接收器。
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公开(公告)号：US20160041380A1
公开(公告)日：2016-02-11
申请号：US14812874
申请日：2015-07-29
Applicant: CELLOMICS, INC.
Inventor： Ronald Albert Kuhn , Kim Anthony Ippolito , Dirk John Vandenberg, III
CPC classification number: G02B21/365 , G02B7/28 , G02B7/36 , G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245 , G02B21/361 , G02B21/367 , H04N5/23212
Abstract: Accurate, reliable, and robust laser-based autofocus solutions are presented for through-the-lens microscope applications using slides or micro-titer plates. The laser-based autofocus solutions solve many of the problems that have arisen due to multiple reflective surfaces at varying distances relative to a sample of interest. The laser-based autofocus solutions provide a unique solution to resolve the ambiguity caused by these multiple reflective surfaces by using an image-based approach.
Abstract translation: 为使用幻灯片或微滴定板的透镜显微镜应用提出了准确，可靠和强大的基于激光的自动对焦解决方案。 基于激光的自动对焦解决方案解决了由于多个反射表面相对于感兴趣的样品而在不同距离处产生的许多问题。 基于激光的自动对焦解决方案提供了一种独特的解决方案，可以通过使用基于图像的方法来解决由这些多个反射面引起的模糊性。
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公开(公告)号：US09075228B2
公开(公告)日：2015-07-07
申请号：US13734748
申请日：2013-01-04
Applicant: Cellomics, Inc.
Inventor： Dirk John Vandenberg, III , Keith R. Heffley
CPC classification number: G02B7/003 , G02B21/00 , G02B26/008 , Y10T29/49817 , Y10T29/49826
Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies. Methods of aligning apertures of optical assemblies with viewing openings of a filter wheel or an optical assembly receiver and securing the optical assemblies to the filter wheel or the optical assembly receiver using a magnetic force.
Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。 将光学组件的孔径与滤光轮或光学组件接收器的观察孔对准的方法，并使用磁力将光学组件固定到滤光轮或光学组件接收器。
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公开(公告)号：US20130105320A1
公开(公告)日：2013-05-02
申请号：US13658263
申请日：2012-10-23
Applicant: Cellomics, Inc.
Inventor： Brent A. Samson , Chandrasekaran Vasudevan , Keith R. Heffley , Joseph M. Zock , Dirk John Vandenberg, III
IPC: B01L9/00 , G01N27/26 , G01N27/447 , G01N27/453
CPC classification number: G01N27/44756 , B01L3/50 , B01L3/5085 , B01L3/50853 , B01L9/00 , G01N27/453
Abstract: A slide holder assembly and method for use in high content screening of a comet assay. The slide holder assembly has an inside surface and is configured to receive a slide holding a plurality of biological cells on a top surface thereof. When the slide is secured within the slide holder assembly, the inside surface of the slide holder assembly and the top surface of the slide combine to form a cavity having an open top end. The cavity is watertight and configured to hold a liquid therein. A method of performing a comet assay using a slide disposed within a slide holder assembly. The method includes performing encapsulation, lysis, electrophoresis, staining, and imaging of cells on the slide while the slide remains secured within the slide holder assembly.
Abstract translation: 用于彗星测定的高含量筛选的载片架组件和方法。 滑动支架组件具有内表面，并且构造成容纳在其顶表面上容纳多个生物细胞的载片。 当滑块固定在滑块保持器组件内时，滑块保持器组件的内表面和滑块的顶表面组合形成具有开放顶端的空腔。 空腔是水密的并且构造成在其中保持液体。 使用设置在载玻片保持器组件内的滑块进行彗星测定的方法。 该方法包括在载玻片保持固定在载玻片保持器组件内时，在载玻片上进行细胞的包封，裂解，电泳，染色和成像。
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