-
公开(公告)号：US10353130B2
公开(公告)日：2019-07-16
申请号：US15504825
申请日：2015-12-08
Applicant: Cellomics, Inc.
Abstract: An apparatus and method of delivering a precisely sized, homogeneous field of light within an optical system. The apparatus operates equally well over UV, visible, and NIR wavelengths, over a wide range of input beam divergence and regardless of heterogeneity. A tapered or contoured homogenizing rod that creates an evenly distributed illumination at a target area of specific size.
-
公开(公告)号：US20040101912A1
公开(公告)日：2004-05-27
申请号：US10685737
申请日：2003-10-15
Applicant: Cellomics, Inc.
Inventor： Richard A. Rubin , Kenneth A. Giuliano , Albert H. Gough , R. Terry Dunlay , Bruce Ray Conway
IPC: G01N033/53 , G01N033/567 , G06K009/00
CPC classification number: G01N33/582 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B01L3/5085 , B82Y5/00 , B82Y30/00 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N33/5008 , G01N33/5014 , G01N33/5035 , G01N33/5076 , G01N33/5079 , G01N33/533 , G01N33/566 , G01N2015/1472 , G01N2015/1479 , G01N2015/1486 , G01N2015/1488 , G01N2015/1497 , G01N2035/00158 , G01N2035/0424 , G01N2333/43595 , G01N2333/726 , G06K9/0014 , C12Q2525/179
Abstract: The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuclear location.
Abstract translation: 本发明提供用于在单个步骤中测量受体内化的系统，方法和屏幕，具有适当的自动化和生产量。 该方法涉及感兴趣受体的发光标记和受体内化至核周位置的自动测量。
-
公开(公告)号：US20220120664A1
公开(公告)日：2022-04-21
申请号：US17501506
申请日：2021-10-14
Applicant: LIFE TECHNOLOGIES CORPORATION , CELLOMICS, INC.
Inventor： Nicolas ROGNIN , Larry RYSTROM , Ognjen GOLUB , Jonathan PAULLIN , Nicholas DILIANI , Kim IPPOLITO
Abstract: Systems and methods for autofocus using artificial intelligence include (i) capturing a plurality of monochrome images over a nominal focus range, (ii) identifying one or more connected components within each monochrome image, (iii) sorting the identified connected components based on a number of pixels associated with each connected component, (iv) generating a focus quality estimate of at least a portion of the sorted connected components using a machine learning module, and (iv) calculating a target focus position based on the focus quality estimate of the evaluated connected components. The calculated target focus position can be used to perform cell counting using artificial intelligence, such as by (i) generating a seed likelihood image and a whole cell likelihood image based on output—a convolutional neural network and (ii) generating a mask indicative quantity and/or pixel locations of objects based on the seed likelihood image.
-
公开(公告)号：US10274715B2
公开(公告)日：2019-04-30
申请号：US14812874
申请日：2015-07-29
Applicant: CELLOMICS, INC.
Inventor： Ronald Albert Kuhn , Kim Anthony Ippolito , Dirk John Vandenberg, III
Abstract: Accurate, reliable, and robust laser-based autofocus solutions are presented for through-the-lens microscope applications using slides or micro-titer plates. The laser-based autofocus solutions solve many of the problems that have arisen due to multiple reflective surfaces at varying distances relative to a sample of interest. The laser-based autofocus solutions provide a unique solution to resolve the ambiguity caused by these multiple reflective surfaces by using an image-based approach.
-
公开(公告)号：US20170276857A1
公开(公告)日：2017-09-28
申请号：US15504825
申请日：2015-12-08
Applicant: Cellomics, Inc.
CPC classification number: G02B6/0008 , G02B6/0061 , G02B21/08 , G02B21/16 , G02B27/0927 , G02B27/0994
Abstract: An apparatus and method of delivering a precisely sized, homogeneous field of light within an optical system. The apparatus operates equally well over UV, visible, and NIR wavelengths, over a wide range of input beam divergence and regardless of heterogeneity. A tapered or contoured homogenizing rod that creates an evenly distributed illumination at a target area of specific size.
-
Patent Agency Ranking
公开(公告)号：US20150260938A1
公开(公告)日：2015-09-17
申请号：US14728685
申请日：2015-06-02
Applicant: CELLOMICS, INC.
Inventor： Dirk John Vandenberg, III , Keith R. Heffley
CPC classification number: G02B7/003 , G02B21/00 , G02B26/008 , Y10T29/49817 , Y10T29/49826
Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies.
Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。
-
公开(公告)号：US20030204316A1
公开(公告)日：2003-10-30
申请号：US10430534
申请日：2003-05-06
Applicant: Cellomics, Inc. , BioDx, Inc.
Inventor： R. Terry Dunlay , D. Lansing Taylor
IPC: C12Q001/00 , G06F019/00 , G01N033/48 , G01N033/50
CPC classification number: B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B01L3/5085 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5005 , G01N33/5035 , G01N33/582 , G01N2015/1486 , G01N2015/1497 , G01N2021/6419 , G01N2021/6482 , G02B21/16 , G02B21/365 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10S977/795 , Y10S977/881 , Y10S977/92 , Y10S977/941 , Y10S977/942 , C12Q2525/179
Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data
Abstract translation: 本发明涉及用于确定荧光标记的报道分子在细胞中的分布，环境或活性的光学系统，以筛选大量用于特定生物活性的化合物。 本发明涉及在荧光显微镜的阵列中提供含有荧光报告分子的细胞，并用荧光显微镜扫描各个位置的多个细胞，将光学信息转换为数字数据，并利用数字数据确定荧光的分布，环境或活性 标记的细胞中的报告分子。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位置微距阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法
-
公开(公告)号：US10393725B2
公开(公告)日：2019-08-27
申请号：US16259072
申请日：2019-01-28
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N33/487 , G01N21/64 , G02B5/02 , G01N21/31 , G01N21/25 , G02B21/36 , G02B21/16 , G01N35/00 , F21Y105/14 , F21Y105/10
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
-
公开(公告)号：US20170248574A1
公开(公告)日：2017-08-31
申请号：US15594978
申请日：2017-05-15
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G01N2201/0631 , G01N2201/064 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
-
公开(公告)号：US09683939B2
公开(公告)日：2017-06-20
申请号：US14709239
申请日：2015-05-11
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N21/25 , G01N21/64 , G02B5/02 , G01N33/487 , F21Y105/00
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
-
-
-
-
-
-
-
-
-
Search Results
30
records
(took 0.013 seconds)
