公开(公告)号：US10526429B2

公开(公告)日：2020-01-07

申请号：US15914409

申请日：2018-03-07

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  Patrick Willoughby ,  Niraj Gurung

IPC: C08F8/06 ,  C08F8/42

Abstract: A method for making a polyisobutylene diol from a polyisobutylene diallyl. The method includes hydroborating the polyisobutylene diallyl to produce a polyisobutylene dialkyl borane, and oxidizing the polyisobutylene dialkyl borane to form the polyisobutylene diol. The polyisobutylene diallyl is hydroborated by combining in situ the polyisobutylene diallyl with a borane-coordinating solvent, an alkaline metal salt of borohydride, and an acid. The alkaline metal salt of borohydride is combined with the polyisobutylene diallyl before the acid is combined with the polyisobutylene diallyl.

公开(公告)号：US20190218334A1

公开(公告)日：2019-07-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/62 ,  C08G18/48 ,  C08G18/40 ,  C08G18/76 ,  A61L31/12 ,  A61L31/14

CPC classification number: C08G18/6208 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  A61L31/129 ,  A61L31/143 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/4063 ,  C08G18/4808 ,  C08G18/4854 ,  C08G18/6204 ,  C08G18/7671 ,  C08G18/833 ,  C08G18/3206 ,  C08L53/00

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US11851522B2

公开(公告)日：2023-12-26

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/12 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

CPC classification number: C08G18/6208 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  A61L31/129 ,  A61L31/143 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/4063 ,  C08G18/4808 ,  C08G18/4854 ,  C08G18/6204 ,  C08G18/7671 ,  C08G18/833 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/12 ,  C08G18/2865 ,  A61L27/16 ,  C08L53/00 ,  A61L31/048 ,  C08L53/00 ,  A61L29/041 ,  C08L53/00

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US20230018482A1

公开(公告)日：2023-01-19

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  C08G18/28 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US11472911B2

公开(公告)日：2022-10-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US20190054204A1

公开(公告)日：2019-02-21

申请号：US16104069

申请日：2018-08-16

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  David R. Wulfman ,  Patrick Willoughby ,  Andrew J. Ro

IPC: A61L27/18 ,  C08J3/24 ,  C08G81/02

Abstract: A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric chains. The plurality of polymeric chains forms a plurality of hard domains and a plurality of soft domains. Each polymeric chain includes a plurality of soft segments and a plurality of hard segments. The plurality of soft segments includes a polyisobutylene diol or diamine residue. The plurality of soft segments forms the plurality of soft domains. The plurality of hard segments including a diisocyanate residue. The plurality of hard segments forms the plurality of hard domains. The cross-linking compound residues link together the hard segments of the plurality of polymeric chains.

公开(公告)号：US20180258196A1

公开(公告)日：2018-09-13

申请号：US15914409

申请日：2018-03-07

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  Andrew J. Ro ,  Patrick Willoughby ,  Niraj Gurung

IPC: C08F8/06 ,  C08F8/42

Abstract: A method for making a polyisobutylene diol from a polyisobutylene diallyl. The method includes hydroborating the polyisobutylene diallyl to produce a polyisobutylene dialkyl borane, and oxidizing the polyisobutylene dialkyl borane to form the polyisobutylene diol. The polyisobutylene diallyl is hydroborated by combining in situ the polyisobutylene diallyl with a borane-coordinating solvent, an alkaline metal salt of borohydride, and an acid. The alkaline metal salt of borohydride is combined with the polyisobutylene diallyl before the acid is combined with the polyisobutylene diallyl.