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    IMPLANTABLE MEDICAL DEVICE COATING FOR WETTING AND MICROBIAL RESISTANCE
    3.
    发明申请
    IMPLANTABLE MEDICAL DEVICE COATING FOR WETTING AND MICROBIAL RESISTANCE 审中-公开
    可浸入式医疗器械用于湿润和微生物耐受性

    公开(公告)号：US20160038743A1

    公开(公告)日：2016-02-11

    申请号：US14822779

    申请日：2015-08-10

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Arthur J. Foster ,  Mathew L. Gilk ,  Keith R. Maile ,  Joseph T. Delaney, JR. ,  Michael Eppihimer ,  Gary T. Seim

    IPC: A61N1/375 ,  C09D171/02

    CPC classification number: A61N1/375 ,  A61N1/05 ,  A61N1/3968 ,  C09D171/02

    Abstract: The present invention relates generally to the materials and methods for improving the wettability of an implantable medical device. More specifically, the invention relates to devices and methods for coating at least a portion of a medical device to improve wettability and reduce electrical impedance. Given the challenges of maintaining consistent and predictable electrical characteristics as implantable medical devices become smaller in size, there remains a continual need to improve wettability in an effort to improve medical outcomes.

    Abstract translation: 本发明一般涉及用于改善可植入医疗装置的润湿性的材料和方法。 更具体地，本发明涉及用于涂覆医疗装置的至少一部分以改善润湿性并降低电阻抗的装置和方法。 考虑到随着可植入医疗器械的尺寸变小，维持一致和可预测的电气特性的挑战，仍然需要持续改善润湿性，以改善医疗结果。

    MEDICAL ELECTRICAL LEAD WITH BIOSTABLE PVDF-BASED MATERIALS
    7.
    发明申请
    MEDICAL ELECTRICAL LEAD WITH BIOSTABLE PVDF-BASED MATERIALS 有权
    医用电导铅与基于PVDF的生物材料

    公开(公告)号：US20170021160A1

    公开(公告)日：2017-01-26

    申请号：US15217178

    申请日：2016-07-22

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Joseph T. Delaney, JR. ,  David R. Wulfman ,  Adeniyi O. Aremu ,  Adegbola O. Adenusi

    IPC: A61N1/05 ,  D01D5/24

    CPC classification number: A61N1/05 ,  A61N1/056 ,  D01D5/24

    Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.

    Abstract translation: 医疗用电线包括从远端区域延伸到近端区域的绝缘引线体，设置在绝缘引线主体内并从近端区域延伸到远端区域的导体，设置在绝缘引线体上并与电接触的电极 与导体和设置在电极的至少一部分上的纤维矩阵。 纤维基质包括纤维。 纤维包括聚偏二氟乙烯（PVDF）聚合物和晶体改性添加剂。 PVDF基聚合物包括非晶PVDF相和结晶PVDF相。 结晶PVDF相包括在结晶PVDF相中超过任何其它结晶结构形式的β型晶体结构。

    PHOTOCROSSLINKED POLYMERS FOR ENHANCED DURABILITY
    8.
    发明申请
    PHOTOCROSSLINKED POLYMERS FOR ENHANCED DURABILITY 审中-公开

    公开(公告)号：US20190054204A1

    公开(公告)日：2019-02-21

    申请号：US16104069

    申请日：2018-08-16

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Joseph T. Delaney, JR. ,  David R. Wulfman ,  Patrick Willoughby ,  Andrew J. Ro

    IPC: A61L27/18 ,  C08J3/24 ,  C08G81/02

    Abstract: A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric chains. The plurality of polymeric chains forms a plurality of hard domains and a plurality of soft domains. Each polymeric chain includes a plurality of soft segments and a plurality of hard segments. The plurality of soft segments includes a polyisobutylene diol or diamine residue. The plurality of soft segments forms the plurality of soft domains. The plurality of hard segments including a diisocyanate residue. The plurality of hard segments forms the plurality of hard domains. The cross-linking compound residues link together the hard segments of the plurality of polymeric chains.

    HYDROBORATION/OXIDATION OF ALLYL-TERMINATED POLYISOBUTYLENE
    9.
    发明申请
    HYDROBORATION/OXIDATION OF ALLYL-TERMINATED POLYISOBUTYLENE 审中-公开

    公开(公告)号：US20180258196A1

    公开(公告)日：2018-09-13

    申请号：US15914409

    申请日：2018-03-07

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Joseph T. Delaney, JR. ,  Andrew J. Ro ,  Patrick Willoughby ,  Niraj Gurung

    IPC: C08F8/06 ,  C08F8/42

    Abstract: A method for making a polyisobutylene diol from a polyisobutylene diallyl. The method includes hydroborating the polyisobutylene diallyl to produce a polyisobutylene dialkyl borane, and oxidizing the polyisobutylene dialkyl borane to form the polyisobutylene diol. The polyisobutylene diallyl is hydroborated by combining in situ the polyisobutylene diallyl with a borane-coordinating solvent, an alkaline metal salt of borohydride, and an acid. The alkaline metal salt of borohydride is combined with the polyisobutylene diallyl before the acid is combined with the polyisobutylene diallyl.

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