公开(公告)号：US20210292788A1

公开(公告)日：2021-09-23

申请号：US17047843

申请日：2019-04-24

Applicant: Cytiva BioProcess R&D AB

Inventor： Asa Hagner McWhirter ,  Anna Akerblom

IPC: C12N15/86 ,  C12N7/00

Abstract: The present invention relates to a method for virus purification. The present invention provides downstream processes for purification of adenovirus from cell culture harvest. More closely, it relates to a method for adenovirus purification using a virus capture and a virus polishing step.

公开(公告)号：US20240261705A1

公开(公告)日：2024-08-08

申请号：US18566551

申请日：2022-06-27

Applicant: Cytiva BioProcess R&D AB

Inventor： Jean-Luc Maloisel ,  Asa Hagner McWhirter ,  Ola Lind ,  Frederic Leroux

IPC: B01D15/36 ,  B01J41/20 ,  C12N7/02

CPC classification number: B01D15/363 ,  B01J41/20 ,  C12N7/02

Abstract: An anion exchange chromatography medium (1) for use in purification of enveloped virus particles or exosomes from a feed, the anion exchange chromatography medium comprising a support material being functionalized with a ligand comprising a diamine functionality generating at least one weak anion exchange group to an ionic capacity of 10-500 μmol/mL.

公开(公告)号：US20250034593A1

公开(公告)日：2025-01-30

申请号：US18913493

申请日：2024-10-11

Applicant: Cytiva BioProcess R&D AB

Inventor： Asa Hagner McWhirter ,  Anna Akerblom

IPC: C12N15/86 ,  C12N7/00 ,  C12N15/861

Abstract: The present invention relates to a method for virus purification. The present invention provides downstream processes for purification of adenovirus from cell culture harvest. More closely, it relates to a method for adenovirus purification using a virus capture and a virus polishing step.

公开(公告)号：US12146149B2

公开(公告)日：2024-11-19

申请号：US17047843

申请日：2019-04-24

Applicant: Cytiva BioProcess R&D AB

Inventor： Asa Hagner McWhirter ,  Anna Akerblom

IPC: C12N15/86 ,  C12N7/00 ,  C12N15/861

Abstract: The present invention relates to a method for virus purification. The present invention provides downstream processes for purification of adenovirus from cell culture harvest. More closely, it relates to a method for adenovirus purification using a virus capture and a virus polishing step.