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    A FUNCTIONALISED CHROMATOGRAPHY MEDIUM LACKING SURFACE EXTENDER
    6.
    发明申请
    A FUNCTIONALISED CHROMATOGRAPHY MEDIUM LACKING SURFACE EXTENDER 有权

    公开(公告)号：US20250153140A1

    公开(公告)日：2025-05-15

    申请号：US18839374

    申请日：2023-02-16

    Applicant: Cytiva BioProcess R&D AB

    Inventor： Jean-Luc Maloisel ,  Frederic Leroux ,  Lisa Marx

    IPC: B01J20/289 ,  B01D15/36 ,  B01D15/38 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

    Abstract: A chromatography medium is provided, comprising a matrix of cellulose-based nanofibers, the nanofibers optionally being crosslinked to one another. A ligand coupled to the matrix without any intermediate extender group. Also provided is a method of preparing a functionalised chromatography medium. The method comprises: (i) providing a substrate comprising cellulose acetate; (ii) forming a fibrous matrix/membrane spun of nanofibers from the substrate; (iii) saponification of the nanofibers to form regenerated cellulose nanofibers; (iv) derivatisation of the regenerated cellulose nanofibers with a cross-linker, and (v) coupling of a ligand to the derivatised cellulose nanofibers, wherein the preparation of the functionalised chromatography medium does not comprise any surface extender. The chromatography medium is useful for separation of large analytes, such as viruses.

    SEPARATION MATRIX AND METHODS FOR SEPARATING TARGET MOLECULES
    7.
    发明申请
    SEPARATION MATRIX AND METHODS FOR SEPARATING TARGET MOLECULES 有权

    公开(公告)号：US20250058298A1

    公开(公告)日：2025-02-20

    申请号：US18712580

    申请日：2022-12-06

    Applicant: Cytiva BioProcess R&D AB

    Inventor： Jean-Luc Maloisel ,  Åsa Hagner McWhirter ,  Ola Lind ,  Ida Helena Vestin ,  Erik Tingborn ,  Björn Norén

    IPC: B01J20/28 ,  B01J20/24 ,  B01J20/282 ,  B01J20/32

    Abstract: The present disclosure is directed to a separation matrix comprising a plurality of chromatography particles, each chromatography particle comprising a core and a layer surrounding the core, wherein the core has a first average pore diameter and the layer surrounding the core has a second average pore diameter, wherein the second average pore diameter is at least 1.5 times higher than the first average pore diameter, wherein the first average pore diameter excludes diffusion of a target molecule through the pores of the core and wherein the second average pore diameter at least partly permits diffusion of the target molecule through the pores of the layer surrounding the core. Further disclosed are a method for preparing such a separation matrix, uses of such a separation matrix and methods for separating target molecules by use of such a separation matrix, in particular a method for separating adeno associated virus capsids fully packaged with genetic material from adeno associated virus capsids not fully packaged with genetic material, and compositions obtained by said method.

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