公开(公告)号：US09997340B2

公开(公告)日：2018-06-12

申请号：US15021362

申请日：2014-09-12

Applicant: DH Technologies Development PTE Ltd.

Inventor： James Hager ,  Christopher M Lock

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0036 ,  H01J49/005 ,  H01J49/063 ,  H01J49/4215

Abstract: A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.

公开(公告)号：US20160225593A1

公开(公告)日：2016-08-04

申请号：US15021362

申请日：2014-09-12

Applicant: DH Technologies Development PTE. Ltd.

Inventor： James Hager ,  Christopher M Lock

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0036 ,  H01J49/005 ,  H01J49/063 ,  H01J49/4215

Abstract: A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.

Abstract translation: 用于同时进行MS / MS分析的质谱仪装置和方法，包括：选择具有指定m / z的前体离子的装置; 充气碰撞池; RF仅多极质谱仪，质谱仪具有附接到其上的发生器，用于在仅RF多极质谱仪中产生至少两个辅助AC场; 用于在RF仅多极质谱仪的出口下游提供排斥的DC或AC屏障的门; 离子检测系统位于DC或AC屏障的下游，用于测量源自克服排斥屏障的离子的离子电流。 质谱仪也可以被配置成使得每个辅助AC场是通过引入各个辅助AC频率而产生的，并且每个频率以唯一的频率进行幅度调制。