-
公开(公告)号：US20210020423A1
公开(公告)日：2021-01-21
申请号：US16971436
申请日：2019-02-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
-
公开(公告)号：US20190006165A1
公开(公告)日：2019-01-03
申请号：US16062936
申请日：2016-12-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik
Abstract: Methods and systems are provided for reducing the occurrence of unwanted electrical discharge when operating an electrospray ion source to generate ions for mass spectrometric analysis. In accordance with various aspects of the applicant's teachings, the methods and systems described herein can provide for controlling the ion emission current so as to limit the onset of avalanche of electrical discharge between the electrospray electrode and the counter electrode under ionization conditions that typically tend to increase the likelihood of such discharge (arcing), while nonetheless providing for maximal ionization efficiency. In various aspects, emission currents between the electrospray electrode and the counter electrode through which the ions are transmitted to a downstream mass analyzer can be maintained at elevated levels, below 10 μA, for example, without the electric potential between the electrospray electrode and the counter electrode initiating the electrical discharge avalanche that results from the dielectric break-down of the air gap therebetween, which can cause sputtering and effect the long-term operation of the ESI source.
-
Patent Agency Ranking
公开(公告)号：US11845099B2
公开(公告)日：2023-12-19
申请号：US16977210
申请日：2019-03-01
Inventor： John J. Corr , Thomas Covey , Peter Kovarik , Michael Bailey , Brett Barnett
CPC classification number: B05B5/03 , G01N30/7266 , H01J49/165 , H01J49/167 , G01N2030/027
Abstract: An electrospray ionization emitter according to various aspects described herein can include an emitter body formed using fused silica. The emitter body can comprise a fluid conduit segment that includes a liquid connection end that has been coated with polyetheretherketone (PEEK) on at least one portion thereof. The liquid connection end can have a first outer diameter that is configured to be connected to a sample source to receive a sample liquid for ionization therefrom. The emitter body can further comprise an ionization discharge segment that is fluidly connected to the fluid conduit segment. The ionization discharge segment can have an ionization discharge end that is coated with a conductive material on at least one portion thereof and configured to have a second outer diameter that allows ionization of the liquid sample.
-
公开(公告)号：US11664210B2
公开(公告)日：2023-05-30
申请号：US16971436
申请日：2019-02-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
CPC classification number: H01J49/107 , H01J49/0031 , H01J49/165
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
-
公开(公告)号：US20210008575A1
公开(公告)日：2021-01-14
申请号：US16977210
申请日：2019-03-01
Inventor： John J. Corr , Thomas Covey , Peter Kovarik , Michael Bailey , Brett Barnett
Abstract: An electrospray ionization emitter according to various aspects described herein can include an emitter body formed using fused silica. The emitter body can comprise a fluid conduit segment that includes a liquid connection end that has been coated with polyetheretherketone (PEEK) on at least one portion thereof. The liquid connection end can have a first outer diameter that is configured to be connected to a sample source to receive a sample liquid for ionization therefrom. The emitter body can further comprise an ionization discharge segment that is fluidly connected to the fluid conduit segment. The ionization discharge segment can have an ionization discharge end that is coated with a conductive material on at least one portion thereof and configured to have a second outer diameter that allows ionization of the liquid sample.
-
公开(公告)号：US20230245877A1
公开(公告)日：2023-08-03
申请号：US18298881
申请日：2023-04-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
CPC classification number: H01J49/107 , H01J49/0031 , H01J49/165
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
-
公开(公告)号：US10818486B2
公开(公告)日：2020-10-27
申请号：US16062936
申请日：2016-12-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik
Abstract: Methods and systems are provided for reducing the occurrence of unwanted electrical discharge when operating an electrospray ion source to generate ions for mass spectrometric analysis. In accordance with various aspects of the applicant's teachings, the methods and systems described herein can provide for controlling the ion emission current so as to limit the onset of avalanche of electrical discharge between the electrospray electrode and the counter electrode under ionization conditions that typically tend to increase the likelihood of such discharge (arcing), while nonetheless providing for maximal ionization efficiency. In various aspects, emission currents between the electrospray electrode and the counter electrode through which the ions are transmitted to a downstream mass analyzer can be maintained at elevated levels, below 10 μA, for example, without the electric potential between the electrospray electrode and the counter electrode initiating the electrical discharge avalanche that results from the dielectric breakdown of the air gap therebetween, which can cause sputtering and effect the long-term operation of the ESI source.
-
-
-
-
-
-
Search Results
7
records
(took 0.015 seconds)
