公开(公告)号：US20240203720A1

公开(公告)日：2024-06-20

申请号：US18287357

申请日：2022-04-15

Applicant: Purdue Research Foundation

Inventor： Julia Laskin ,  Pei Su ,  Carlos Larriba ,  Xi Chen

IPC: H01J49/06 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16

CPC classification number: H01J49/066 ,  H01J49/0468 ,  H01J49/107 ,  H01J49/165

Abstract: The invention generally relates to systems and methods for systems and methods for multiplexed electrospray ionization. In certain embodiments, electrospray ionization sources orthogonally inject ions into an ion funnel with at least two of the sources injecting on the same side of the ion funnel.

公开(公告)号：US20190244799A1

公开(公告)日：2019-08-08

申请号：US16209130

申请日：2018-12-04

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Ruth Merrifield

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Certain configurations of systems comprising a cell analyzer and a mass spectrometer are described. In some embodiments, the system can be used to determine both a cell phenotype or cellular response and an amount of at least one elemental species in the cell. The phenotype or other cellular characteristic and elemental content of each cell in a cell population can be determined and correlated.

公开(公告)号：US10304667B1

公开(公告)日：2019-05-28

申请号：US15842729

申请日：2017-12-14

Applicant: Thermo Finnigan LLC

Inventor： Steven L. Reeber ,  Cornelia L. Boeser

IPC: H01J49/04 ,  H01J37/32 ,  H01J49/26 ,  H01J49/10

CPC classification number: H01J37/32862 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/107 ,  H01J49/24 ,  H01J49/26

Abstract: A method of removing sample residue from a surface of a mass spectrometer inlet, with the surface being adjacent to an ion passageway, is provided. A pendent droplet of a cleaning solvent is formed at a tip of a capillary, with the tip being spaced apart from the surface. The pendent droplet detaches from the tip and contacts the surface. The surface is heated to a temperature T at least 50° C. above the boiling point of the least volatile component of the cleaning solvent.

公开(公告)号：US20180372696A1

公开(公告)日：2018-12-27

申请号：US15780829

申请日：2015-12-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC classification number: G01N30/724 ,  G01N27/62 ,  G01N30/72 ,  G01N30/7273 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/107 ,  H01J49/165

Abstract: A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

公开(公告)号：US20180190478A1

公开(公告)日：2018-07-05

申请号：US15845419

申请日：2017-12-18

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong ,  Hamid Badiei ,  William Fisher

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/42

CPC classification number: H01J49/009 ,  H01J49/107 ,  H01J49/4225

Abstract: Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.

公开(公告)号：US09852897B2

公开(公告)日：2017-12-26

申请号：US14442199

申请日：2013-11-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hideki Hasegawa ,  Hiroyuki Satake ,  Masao Suga ,  Yuichiro Hashimoto

IPC: H01J49/10 ,  G01N27/62 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N27/62 ,  H01J49/165 ,  H01J49/168

Abstract: Provided is an ion source achieving high sensitivity and high robustness while executing a plurality of types of ionization schemes. To this end, a hybrid ion source (1) includes: a chamber (24); a first ion source (2) to spray a sample solution (5) for ionization; a second ion source (3) to ionize droplets and/or a gas component sprayed from the first ion source (2); a first electrode (11) to introduce a first ion (7) generated by the first ion source (2), and a second ion generated by the second ion source (3); and an exhaust pump (27) that generates air flow (26) in a direction from a first space area (23) where the first ion (7) is generated to a second space area (19) in the second ion source (3) where the second ion is generated.

公开(公告)号：US20170309463A1

公开(公告)日：2017-10-26

申请号：US15135679

申请日：2016-04-22

Applicant: Morpho Detection, LLC

Inventor： Andrey N. Vilkov

IPC: H01J49/16 ,  G01N27/62 ,  H01J49/04 ,  H01J49/26

CPC classification number: H01J49/161 ,  G01N27/622 ,  G01N27/628 ,  H01J49/0409 ,  H01J49/107 ,  H01J49/162 ,  H01J49/26

Abstract: A dual source ionizer is provided. The dual source ionizer includes a first photoionization source configured to emit low flux ultraviolet (UV) light to generate primarily NO3− ions, and a second photoionization source configured to emit high flux UV light to generate primarily ions other than NO3− ions.

公开(公告)号：US20170191962A9

公开(公告)日：2017-07-06

申请号：US14666856

申请日：2015-03-24

Applicant: MORPHO DETECTION, LLC

Inventor： Andrey N. Vilkov ,  Jack A. Syage

IPC: G01N27/62 ,  G01N33/00 ,  G01N33/22 ,  H01J37/08 ,  H01J49/10

CPC classification number: G01N27/622 ,  G01N33/0036 ,  G01N33/227 ,  H01J37/08 ,  H01J49/107

Abstract: A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx− ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx− ions.

公开(公告)号：US09666422B2

公开(公告)日：2017-05-30

申请号：US14891123

申请日：2014-08-29

Applicant: ATONARP INC.

Inventor： Prakash Sreedhar Murthy

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/14 ,  H01J49/10

CPC classification number: H01J49/0031 ,  H01J49/025 ,  H01J49/06 ,  H01J49/107 ,  H01J49/147

Abstract: There is provided an analyzer including: an ionizer unit that ionizes molecules to be analyzed; a filter unit that selectively passes ions generated by the ionizer unit; and a detection unit that detects ions that have passed the filter unit. The detection unit includes a plurality of detection elements disposed in a matrix, and the analyzer further includes a first reconfiguration unit that switches between detection patterns including detection elements to be enabled for detection out of the plurality of detection elements. The ionizer unit includes a plurality of ion sources, and the analyzer further includes a driving control unit that switches the connections of the plurality of ion sources based on changes in characteristics of the ion sources.

公开(公告)号：US09589776B2

公开(公告)日：2017-03-07

申请号：US15070433

申请日：2016-03-15

Applicant: SRI INTERNATIONAL

Inventor： Ashish Chaudhary ,  Friso Van Amerom ,  R. Timothy Short

IPC: H01J49/00 ,  H01J49/24

CPC classification number: H01J49/0027 ,  H01J49/0013 ,  H01J49/004 ,  H01J49/0054 ,  H01J49/0059 ,  H01J49/107 ,  H01J49/24

Abstract: A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry.

Abstract translation: 双电离质谱仪包括形成硬电离质谱仪的第一质谱模块，形成软电离质谱仪的第二质谱仪，位于第一和第二模块之间的真空紫外光源，包含第一和第二 一组板和光源，以及定位成接收分析物样品并将其提供给至少一组板的入口。 检测物质的方法包括通过入口将分析物的样品接收到壳体中，通过壳体中的软质电离质谱仪对样品进行软质电离质谱分析，用硬质电离光谱仪对样品进行硬质离子化分光光度法 如果需要，在壳体中，并且从至少一种软电离光谱法和硬质电离光谱法产生检测结果。