公开(公告)号：US20240112901A1

公开(公告)日：2024-04-04

申请号：US18257611

申请日：2021-12-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Chang LIU ,  Thomas COVEY ,  Peter KOVARIK

IPC: H01J49/06 ,  H01J49/16

CPC classification number: H01J49/068 ,  H01J49/165

Abstract: A method of adjusting a position of an electrode within a nebulizer probe of a mass spectrometry device having an open port interface for receiving a sample includes performing a first analysis of the sample at a first analysis condition including a first position of the electrode and a first flow rate. After performing the first analysis, a second analysis of the sample is performed at a second analysis condition including the first position of the electrode and a second flow rate higher than the first flow rate. Thereafter, a third analysis of the sample is performed at a third analysis condition including a second position of the electrode and the second flow rate.

公开(公告)号：US20230377867A1

公开(公告)日：2023-11-23

申请号：US18031240

申请日：2021-10-11

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas COVEY ,  Peter KOVARIK

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/167

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a specimen may be received within an open port of a sampling probe and continuously delivered via a jet pump assembly to an ion source for subsequent mass spectrometric analysis.

公开(公告)号：US20240395527A1

公开(公告)日：2024-11-28

申请号：US18689467

申请日：2022-09-09

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/24

Abstract: A method of ejecting a sample from a nebulizer nozzle fluidically coupled to a port via a transfer conduit includes receiving at the port a transport liquid and the sample. The transport liquid and the sample in the transfer conduit is transported from the port to a transfer conduit exit comprising an electrode tip. The transport liquid is ejected from the transfer conduit exit. The sample is ejected from the transfer conduit exit substantially simultaneously with ejecting the transport liquid. During ejection of the transport liquid and the sample from the transfer conduit exit, a pressure is generated at the transfer conduit exit substantially similar to a vapor pressure of the transport liquid.

公开(公告)号：US20240079225A1

公开(公告)日：2024-03-07

申请号：US18262829

申请日：2022-02-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Peter KOVARIK

IPC: H01J49/24 ,  F17D1/00 ,  G01N1/10 ,  G01N35/10 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/24 ,  F17D1/005 ,  G01N1/10 ,  G01N35/1095 ,  H01J49/0404 ,  H01J49/167 ,  B67D99/00

Abstract: A method of delivering transport fluid from an open port interface to an outlet via a transfer conduit includes delivering, to the open port interface, a transport liquid at a first flow rate. The open port interface is disposed in a pressure environment having a first pressure. A second pres-sure is applied at the outlet, wherein the second pressure is less than the first pressure. The pressure applied at the outlet generates a motive flow on the transport liquid, thereby drawing into the transfer conduit (a) the transport fluid, wherein the transport fluid is in contact with a wall of the transport conduit, and (b) a gas present in the pressure environment. The gas forms an air core within the drawn transport fluid. The air core extends substantially an entire length of the transfer conduit.

公开(公告)号：US20160181078A1

公开(公告)日：2016-06-23

申请号：US14910044

申请日：2014-08-05

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Peter KOVARIK

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/0445 ,  B01D19/0042 ,  H01J49/0431 ,  H01J49/16

Abstract: Methods and systems for delivering a liquid sample to an ion source are provided herein. In various aspects, the methods and systems can improve the stability of a flow of liquid sample delivered to an ion source. In accordance with various aspects, the methods and systems can remove bubbles (e.g., cavitation bubbles or otherwise) present in the liquid sample prior to its injection into an ionization chamber.

Abstract translation: 本文提供了将液体样品输送到离子源的方法和系统。 在各个方面，所述方法和系统可以提高输送到离子源的液体样品流的稳定性。 根据各个方面，所述方法和系统可以在液体样品注入电离室之前去除存在于液体样品中的气泡（例如气泡或其它物质）。

公开(公告)号：US20240331992A1

公开(公告)日：2024-10-03

申请号：US18293399

申请日：2022-07-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK ,  John J. CORR

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/167

Abstract: A liquid handling system for a mass spectrometer (MS), the liquid handling system including an open port interface (OPI) including a body defining a port and an internal volume. At least one removal conduit is disposed in the body and fluidically coupled to the internal volume. A plurality of transfer conduits is fluidically coupled to the at least one removal conduit. A single one of a plurality of nebulizer nozzles are fluidically coupled to each of the plurality of transfer conduits.

公开(公告)号：US20240170271A1

公开(公告)日：2024-05-23

申请号：US18552685

申请日：2022-03-30

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK ,  Thomas R. COVEY ,  Bradley B. SCHNEIDER

IPC: H01J49/04 ,  H01J49/14 ,  H01J49/16

CPC classification number: H01J49/0404 ,  H01J49/0431 ,  H01J49/145 ,  H01J49/165

Abstract: A method of analyzing a liquid with a mass analysis device having a bubble generating interface (BGI) and a removal conduit includes aspirating a sample into the removal conduit at an aspira-tion pressure. Concurrently with aspirating the sample at least one operational condition of the BGI is controlled to generate a plurality of bubbles in the sample. Concurrently with aspirating the sample the plurality of bubbles are aspirated into the removal conduit. The sample and the plurality of bubbles are analyzed with the mass analysis device to generate a signal.

公开(公告)号：US20240170270A1

公开(公告)日：2024-05-23

申请号：US18550016

申请日：2022-03-22

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK ,  Bradley B. SCHNEIDER ,  Thomas R. COVEY

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/0404 ,  H01J49/0431 ,  H01J49/165

Abstract: A method of evacuating a liquid sample from an open port interface (OPI) via a pressure drop includes applying the pressure drop to a transport liquid. This application generates a plurality of bubbles in the transport liquid during evacuation of the transport liquid from the OPI via a transfer conduit. The liquid sample is separated from a subsequent liquid sample by at least one of the generated bubbles.

公开(公告)号：US20240096614A1

公开(公告)日：2024-03-21

申请号：US18261918

申请日：2022-01-20

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Peter KOVARIK ,  Chang LIU

IPC: H01J49/16

CPC classification number: H01J49/167

Abstract: A method of adjusting a position of a tip of an electrode relative to an end of a nebulizer nozzle of a mass spectrometry device includes providing a conduit and the electrode connected to the conduit at a first end of the conduit. The electrode tip is disposed at a first position relative to the nebulizer nozzle end. The pressure gauge is connected to a second end of the conduit. A gas ejection is initiated from the nozzle with the electrode tip at the first position. During the gas ejection, the position of the electrode tip is adjusted from the first position towards a second position relative to the nozzle end. Adjusting the position from the first position towards the second position is terminated when the pressure gauge displays a pressure condition. Once adjusting is terminated, the electrode tip is at the second position.