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1.发明公开公开(公告)号：US20240355603A1
公开(公告)日：2024-10-24
申请号：US18693343
申请日：2022-09-21
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Anjali CHELUR , Stephen TATE
IPC: H01J49/00
CPC classification number: H01J49/0031 , H01J49/0036
Abstract: In one aspect, a method of operating a mass spectrometer is disclosed, which comprises ionizing a sample to generate a plurality of ions, and introducing at least a portion of the ions into an inlet orifice of the mass spectrometer. At least a portion of the ions and/or fragments thereof is detected by a downstream detector to generate a plurality of ion detection events, and the ion detection events are monitored to determine an ion count. The ion count is compared with a reference level to determine whether the detected level exceeds the reference level.
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2.发明公开公开(公告)号：US20240258090A1
公开(公告)日：2024-08-01
申请号：US18560458
申请日：2022-05-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Yves LE BLANC , Stephen TATE
CPC classification number: H01J49/0031 , H01J49/165
Abstract: Systems and methods for performing mass analysis. An example method may include ejecting, from a first well of a well plate, a first sample into a transport fluid; ionizing the first sample and the transport fluid to generate first ions; detecting the first ions over a first period of time; and when a count rate of the detected first ions is above a background count rate threshold, accumulating a count of the detected first ions. The method may also include ejecting, from a second well of the well plate, a second sample into the transport fluid; ionizing the second sample and the transport fluid to generate second ions; detecting the second ions over a second period of time; and when a count rate of the detected second ions is above the background count rate threshold, accumulating a count of the detected second ions.
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公开(公告)号：US20230410952A1
公开(公告)日：2023-12-21
申请号：US18035231
申请日：2021-11-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Stephen TATE , Charles Andrew Hugh BAKER
CPC classification number: G16C20/20 , G16C20/90 , H01J49/0036
Abstract: Methods and systems for generating verified mass analysis results for a sample. An example method may include acquiring process data for performing a mass analysis test on the sample; performing, by a mass analysis instrument, the mass analysis test based on the acquired process data to generate mass analysis results for the sample; recording machine-level characteristics for the mass analysis instrument during the mass analysis test; generating verification data that includes at least a portion of the recorded machine-level characteristics; generating a secure analytical data file that includes the verification data and at least a portion of the mass analysis results; and transmitting the secure analytical data file.
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公开(公告)号：US20240395522A1
公开(公告)日：2024-11-28
申请号：US18693311
申请日：2022-09-19
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Gordana IVOSEV , Chang LIU , Stephen TATE , Hui ZHANG
IPC: H01J49/00
Abstract: A method for performing mass spectrometry (MS) comprises receiving MS data corresponding to a plurality of MS runs, wherein MS data corresponding to an MS run of the plurality of MS runs comprises detected intensities for a plurality of mass over charge ratios (MZ values) during the MS run; finding a recurrent MZ value of the plurality of MZ values, wherein a detected intensity for the recurrent MZ value appears as a recurrent peak in MS data corresponding to a subset of the plurality of MS runs; and the subset of the plurality of MS runs includes at least two MS runs of the plurality of MS runs; and identifying the recurrent MZ value as corresponding to a background ion.
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5.发明申请公开(公告)号：US20240377369A1
公开(公告)日：2024-11-14
申请号：US18689600
申请日：2022-09-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Eva DUCHOSLAV , Pradeep NARAYANASWAMY , Stephen TATE
Abstract: Methods and systems for identifying analytes in a sample using mass spectrometry are provided. A method for identifying analytes in mass spectrometry data comprises: introducing a sample to a mass spectrometer; analyzing the sample with the mass spectrometer in a plurality of cycles; generating, for each cycle, a mass spectrum comprising at least one peak; annotating peaks in the mass spectrum based on their relationships; assigning best ion types to each peak; processing each cycle of the mass spectrum to assign a score to each of the at least one peak thereof with respect to the likely neutral mass related to the peak; grouping peaks that share a common neutral mass; and outputting the analyte neutral mass.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20240371474A1
公开(公告)日：2024-11-07
申请号：US18689522
申请日：2022-09-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Eva DUCHOSLAV , Pradeep NARAYANASWAMY , Stephen TATE
Abstract: Methods and systems for building and using an analyte library are provided. One aspect is a method for building an analyte library, the method comprising receiving mass spectrum data from analysis of a sample using mass spectrometry, mass spectrum data including a mass spectrum and a sample matrix, and the sample including an analyte, identifying peaks in the mass spectrum, assigning at least one ion type to the peaks, annotating the peaks for the analyte based on the sample matrix, extracting an ion fingerprint for the analyte based on the annotated peaks and storing an analyte identification entry including the ion fingerprint for the analyte.
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公开(公告)号：US20240175787A1
公开(公告)日：2024-05-30
申请号：US18547787
申请日：2022-02-24
Applicant: Stephen TATE , Andras GUTTMAN , DH Technologies Development Pte. Ltd.
Inventor： Stephen TATE , Yves LE BLANC , Thomas R. COVEY
CPC classification number: G01N1/14 , G01N1/38 , G01N30/7233 , G01N2001/149 , G01N2030/027
Abstract: A system includes a capillary having a first end connected to a sampling device and a second end. The sampling device is configured to separate a sample with a separation solution and deliver the sample and the separation solution to the second end. The second end is coupled to a capillary ground contact. A transport liquid supply system in fluidic communication with a transport liquid supply conduit provides a transport liquid from a transport liquid source through the transport liquid supply conduit. The transport liquid provided from the transport liquid supply conduit includes a receiving volume defined at least in part by a meniscus. The second end of the capillary is in fluidic communication with the receiving volume. A liquid exhaust system in fluidic communication with a removal conduit removes liquid from the receiving volume. An analysis system is in fluidic communication with the removal conduit.
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公开(公告)号：US20250079143A1
公开(公告)日：2025-03-06
申请号：US18714055
申请日：2022-12-06
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Stephen TATE
IPC: H01J49/04
Abstract: Systems, apparatus, and computer-readable storage media are disclosed for analyzing samples of a well plate. Systems may include a well plate, a mass spectrometer, and a computing device. The well plate may include rows of wells. The mass spectrometer may sequentially capture a sample from each well of the rows of wells and generate spectral data that includes mass spectrum data for each captured sample. The computing device may receive the spectral data generated by the mass spectrometer, detect rows of spectral data in the spectral data, wherein each row of spectral data corresponds to a row of wells in the well plate; and generate a spectral data matrix from the detected rows of spectral data such that each row of wells comprises a corresponding row of spectral data in the spectral data matrix.
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公开(公告)号：US20240347141A1
公开(公告)日：2024-10-17
申请号：US18689543
申请日：2022-09-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Eva DUCHOSLAV , Pradeep NARAYANASWAMY , Stephen TATE
CPC classification number: G16C20/20 , G16C20/70 , H01J49/0036
Abstract: Methods and systems for identifying one or more analytes in a sample are provided. One aspect is a method of predicting an identity of analytes in an unknown sample, the method comprising accessing a database comprising a plurality of results from analyzing samples using mass spectrometry to identify analytes, the plurality of results including annotated ion fingerprints, training a machine learning model with the plurality of results, and applying the machine learning model to the unknown sample to predict an identity of one or more analytes in the unknown sample.
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公开(公告)号：US20240255467A1
公开(公告)日：2024-08-01
申请号：US18561031
申请日：2022-05-18
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Leigh BEDFORD , Bradley B. SCHNEIDER , Eva DUCHOSLAV , Stephen TATE
IPC: G01N27/623 , G01N27/624 , H01J49/16
CPC classification number: G01N27/623 , G01N27/624 , H01J49/165
Abstract: A method of operating a system including a differential mobility spectrometer (DMS) and a mass spectrometer. A sample is introduced to the DMS. The sample is analyzed with the DMS. Data is generated based at least in part on an analyte ion generated from the sample and at least one transport gas composition. Library data of the analyte ion is accessed from a library. The generated data is compared to the library data. A signal is sent when the generated data deviates from the library data by more than a predetermined threshold.
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