公开(公告)号：US20070041875A1

公开(公告)日：2007-02-22

申请号：US11507067

申请日：2006-08-18

Applicant: David Bach ,  Ronald Genova

Inventor： David Bach ,  Ronald Genova

IPC: B01L3/02

CPC classification number: B01L3/021 ,  B01L2200/143 ,  B01L2400/0487 ,  G01N35/10 ,  G01N2035/1034 ,  G01N2035/1062

Abstract: An improved needle and nozzle design that allows for precision dispensing and mixing of fluids by assist of an integral optical system coupled to a closed loop controller drive system for real-time monitoring of the small volume precision dispensing requirements of bioscience applications. The needles/nozzles have an optically-transmissive wall or window coupled to an optical system including an optical detector and light source, at least the detector being connected to a closed loop controller drive system (e.g., a “needle/nozzle integrated optical analysis system”). Optical detection can be based on fluorescence, scattered light, absorbance, or a combination, and any optical change in the analysis region can be observed via the transmitted/reflected light and used as feedback to control the pump drive system. Alternate embodiments are shown in which optical fibers or rods are used for coupling the detector to the needle/nozzle, and a lens is used for coupling the fiber(s)/rods into the needle/nozzle.

Abstract translation: 改进的针头和喷嘴设计，通过协助耦合到闭环控制器驱动系统的整体光学系统，实现对生物科学应用的小体积精确分配要求的实时监控，从而允许流体的精确分配和混合。 针/喷嘴具有耦合到包括光学检测器和光源的光学系统的光学透射壁或窗口，至少检测器连接到闭环控制器驱动系统（例如，“针/喷嘴集成光学分析系统 “）。 光学检测可以基于荧光，散射光，吸光度或组合，并且可以通过透射/反射光观察分析区域中的任何光学变化，并用作控制泵驱动系统的反馈。 示出了替代实施例，其中使用光纤或棒将检测器耦合到针/喷嘴，并且使用透镜来将纤维/杆连接到针/喷嘴中。

公开(公告)号：US07175811B2

公开(公告)日：2007-02-13

申请号：US09845489

申请日：2001-04-30

Applicant: David Bach ,  Bruce L. Booth ,  James C. Richards

Inventor： David Bach ,  Bruce L. Booth ,  James C. Richards

IPC: G01N21/01

CPC classification number: G01N21/648 ,  B01J2219/00274 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/7786 ,  G02B6/138

Abstract: Novel nanowell microarrays are disclosed in optical contact with polymer waveguides wherein evanescent field associated with lightwaves propagated in the waveguide excite target substances in the nanowells either by a common waveguide or by individual waveguides. Fluid samples are conveyed to the nanowells by means of microfluidics. The presence of the target substances in fluid samples is detected by sensing fluorescent radiation generated by fluorescent tag bound to the target substances. The fluorescent tags generate fluorescent radiation as a result of their excitation by the evanescent field. One or more PMT detectors or a CCD detector are located at the side of the waveguide opposite to the nanowells. Fluorescent radiation is detected due to its coupling with the waveguide or its emission through the waveguide.

Abstract translation: 公开了与聚合物波导光学接触的新型纳米线微阵列，其中与波导中传播的光波相关联的消逝场通过公共波导或通过单个波导激发纳米孔中的目标物质。 流体样品通过微流体传送到纳米管。 通过检测与目标物质结合的荧光标记产生的荧光辐射来检测流体样品中目标物质的存在。 荧光标签由于其消逝场的激发而产生荧光辐射。 一个或多个PMT检测器或CCD检测器位于与纳米孔相对的波导侧。 荧光辐射由于其与波导的耦合或其通过波导的发射而被检测。

公开(公告)号：US20060115379A1

公开(公告)日：2006-06-01

申请号：US11273583

申请日：2005-11-14

Applicant: David Bach ,  Muniswamappa Anjanappa

Inventor： David Bach ,  Muniswamappa Anjanappa

IPC: G01N33/00

CPC classification number: F04B43/04 ,  F04B17/04

Abstract: A multi-valved positive displacement pump design that employs a magnetostrictive fluid pump in combination with magnetostrictive gates. The pump generally comprises a pump housing defining an internal fluid chamber, an inlet port to the fluid chamber, an outlet port from the fluid chamber, a magnetostrictive positive displacement pump in the fluid chamber, and magnetostrictive gates (valves) selectably blocking the inlet port to the fluid chamber and the outlet port from the fluid chamber. All pump and gate actuators include rods formed of magnetostrictive material (seated in the housing), and coil windings for electrical excitation to vary the length of the rods. The pump and valves are operated under PLC control according to a pumping sequence comprising a fluid induction step wherein the pump and inlet actuator rods are retracted and the outlet actuator rod is extended to open the inlet port and induct fluid into the fluid chamber, and a fluid dispensing step wherein the pump and inlet actuator rods are extended and the outlet actuator rod is retracted to close the inlet port and expel fluid from the fluid chamber. The positive displacement pump has particular utility in the context of a cell sorter system for sorting desired cells from undesired matter, and an embodiment thereof is also disclosed.

Abstract translation: 采用磁致伸缩流体泵与磁致伸缩门结合的多阀正排量泵设计。 泵通常包括限定内部流体室的泵壳体，流体室的入口端口，来自流体室的出口端口，流体室中的磁致伸缩容积泵，以及可选地阻挡入口端口的磁致伸缩门 从流体室流到流体室和出口。 所有泵和门执行器都包括由磁致伸缩材料（位于壳体中）形成的杆和用于电激励的线圈绕组以改变杆的长度。 泵和阀根据包括流体诱导步骤的泵送顺序在PLC控制下操作，其中泵和进口致动器杆缩回并且出口致动器杆被延伸以打开入口端口并将流体引入流体室，并且 流体分配步骤，其中泵和入口致动器杆被延伸并且出口致动器杆缩回以关闭入口端口并从流体室排出流体。 正位移泵在细胞分选系统的上下文中具有特别的用途，用于从期望的物质分选所需的细胞，并且还公开了其实施方案。

公开(公告)号：US20060010963A1

公开(公告)日：2006-01-19

申请号：US10965289

申请日：2004-10-14

Applicant: David Bach ,  Muniswamappa Anjanappa

Inventor： David Bach ,  Muniswamappa Anjanappa

IPC: G01N11/00

CPC classification number: G01N11/00 ,  G01N9/36 ,  G01N27/72 ,  G01N2011/0086 ,  G01N2291/02863

Abstract: A system for making dynamic measurement of viscosity or density of a fluid using magnetostrictive particles. Magnetostrictive particles are placed in contact or proximity with a fluid where they can experience stress caused by the viscosity of the fluid when they expand, contract or otherwise move. A alternating or otherwise changing magnetic field is applied to the system causing the particles to expand and contract. A sense coil detects a total magnetic field that is a superposition of the applied field and a field generated in the magnetostrictive particles as they expand and contract. The amplitude of this sensor is related to the viscosity. The applied magnetic field can also be swept in frequency with the location of a resonance also indicating viscosity or density.

Abstract translation: 一种使用磁致伸缩颗粒动态测量流体的粘度或密度的系统。 磁致伸缩颗粒放置在与流体接触或接近的位置，当它们膨胀，收缩或以其它方式移动时，它们可以经受由流体粘度引起的应力。 交替或其他变化的磁场被施加到系统，导致颗粒膨胀和收缩。 感测线圈检测作为施加场的叠加的总磁场和在磁致伸缩颗粒膨胀和收缩时产生的磁场。 该传感器的振幅与粘度有关。 所施加的磁场也可以频率扫过，同时也指示粘度或密度的共振位置。

公开(公告)号：US20050194407A1

公开(公告)日：2005-09-08

申请号：US11074589

申请日：2005-03-08

Applicant: David Bach

Inventor： David Bach

IPC: B01F5/12 ,  B01L3/02 ,  F04B7/04 ,  F04B13/00 ,  B65D88/54 ,  G01F11/06 ,  G01F11/30 ,  G01F11/36 ,  G01F11/42

CPC classification number: G01F11/029 ,  B01F5/12 ,  B01L3/0206 ,  B01L3/0227 ,  B01L2400/0622 ,  F04B7/04 ,  F04B13/00

Abstract: A precision fluid dispensing system containing a two-piece pump and a precision closed loop controller drive system to address the small volume precision dispensing requirements of bioscience applications. A multiple diameter pump can be combined with a pump having multiple inlet and outlet ports to allow for precision multiple outlet dispenses in a single pump that finds use with microtiter plate pipetting and other precision dispensing. Inlet ports can be located on the smaller diameter of the cylinder with outlet ports on the larger diameter of the cylinder. A dual piston, dual cylinder pump can be used where the upper and lower parts are different diameters and the two pistons are coupled with a fluid layer.

Abstract translation: 精密流体分配系统，包含两件式泵和精密闭环控制器驱动系统，以满足生物科学应用的小体积精密分配要求。 多直径泵可以与具有多个入口和出口的泵组合，以允许精确的多个出口分配在单个泵中，其可用于微量滴定板移液和其它精确分配。 入口端口可以位于气缸的较小直径上，出口端口在气缸的较大直径上。 可以使用双活塞双缸泵，其中上部和下部具有不同的直径，并且两个活塞与流体层联接。

公开(公告)号：US20050180856A1

公开(公告)日：2005-08-18

申请号：US11036782

申请日：2005-01-14

Applicant: David Bach

Inventor： David Bach

IPC: F04B43/00 ,  F04B43/12 ,  F04B49/06 ,  F04B49/00 ,  F04B17/00

CPC classification number: F04B9/02 ,  F04B13/00 ,  F04B17/03 ,  F04B43/0081 ,  F04B43/12 ,  F04B43/1253 ,  F04B49/065 ,  F04B2201/1208 ,  F04B2203/0213

Abstract: A method and system for controlling a rotary pump where a rotary pump can be coupled to a stepper motor, and the stepper motor can be controlled with micro- or nano-stepping accuracy using a processor controlled drive system. The processor controlled drive system moves the stepper motor according to a predetermined move profile; this causes the rotary pump to dispense a precision amount of fluid. The rotary pump can be a peristaltic pump or any other type of pump. The rotary pump can be coupled to the stepper motor through a reduction gear with a reduction ratio of 2:1 or similar. The stepper motor can be mechanically coupled to a rotational position encoder so that a measure of the rotation position can be fed back to the processor. The processor can cause the stepper motor to interpolate between pulse positions of the encoder.

Abstract translation: 一种用于控制旋转泵的方法和系统，其中旋转泵可以耦合到步进电动机，并且步进电机可以使用处理器控制的驱动系统以微步或微步进精度来控制。 处理器控制的驱动系统根据预定的移动轮廓移动步进马达; 这使得旋转泵分配精确量的流体。 旋转泵可以是蠕动泵或任何其他类型的泵。 旋转泵可以通过减速比2:1或类似的减速齿轮联接到步进电机。 步进电机可以机械地耦合到旋转位置编码器，使得可以将旋转位置的测量值反馈给处理器。 处理器可以使步进电机在编码器的脉冲位置之间插值。

公开(公告)号：US4603769A

公开(公告)日：1986-08-05

申请号：US631099

申请日：1984-07-16

Applicant: Bert Bach ,  David Bach

Inventor： Bert Bach ,  David Bach

IPC: B65G69/18 ,  B65G11/06 ,  B65G1/00 ,  B65G11/00

CPC classification number: B65G69/181 ,  B65G65/32

Abstract: In a grain elevator, grain mixed with dust is delivered near the top of a grain silo to the receiving orifice of a grain chute. The chute includes an enclosed conduit which extends from the top of the grain silo to its floor and deposits the grain in the silo without freely falling in the interior of the silo. The conduit has a tandem column series of vertically extending doors which are counter-balanced to be normally closed and which are opened by the weight of the grain in the conduit. The fall of the grain within the conduit separates the grain from the dust and the dust is removed by an exhaust fan connected to the conduit, the air flow being through the open bottom doors of the conduit, through the conduit, and out of the silo to a tube connected to a dust separator. In addition, the grain falls within the conduit and flows out of the doors which the grain column opens and which are immediately above the level of the grain already delivered into the silo, the other doors remaining closed.

Abstract translation: 在粮食升降机中，与灰尘混合的谷物在谷仓的顶部附近传送到粮食槽的接收孔。 滑槽包括封闭的导管，其从谷仓的顶部延伸到其地板并将谷物沉积在料仓中，而不会自动落入料仓的内部。 导管具有串列系列的垂直延伸的门，其平衡平衡以常闭，并且由导管中的颗粒的重量打开。 导管内的谷物的坠落将颗粒与灰尘分开，灰尘通过连接到导管的排气风扇除去，空气流通过导管的敞开的底部门，通过导管，并且进出筒仓 连接到与灰尘分离器连接的管。 此外，谷物落在导管内并流出谷物柱开口的门，并且立即在已经输送到料仓中的谷物的水平面上方，其他门保持关闭。

公开(公告)号：US20110286870A1

公开(公告)日：2011-11-24

申请号：US13114266

申请日：2011-05-24

Applicant: David Bach

Inventor： David Bach

IPC: F04B43/08 ,  B23P17/00

CPC classification number: F04B43/1292 ,  F04B43/1261 ,  Y10T29/49229

Abstract: An enhancement for a peristaltic pump that, in a particular embodiment, can be a thin concave spring member or other mechanism with at least one tubing notch adapted to be mounted on a peristaltic pump frame such that peristaltic pump tubing can pass through a notch in the spring member, through the peristaltic pump and through a notch in a similar thin concave spring member mounted on an opposite side of said peristaltic pump so that the spring members prevent tube-stretching or deformation of the tubing. Numerous other embodiments are possible. All of the embodiments allow attaching a first and second notched spring-clamp or other tubing holder onto the input and output sides of a peristaltic pump frame; threading peristaltic pump tubing through a notch or other part in a first spring-clamp or tubing holder, through the peristaltic pump and through a notch or other part in a second spring-clamp or tubing holder.

Abstract translation: 在特定实施例中，蠕动泵的增强可以是薄的凹形弹簧构件或具有适于安装在蠕动泵框架上的至少一个管道切口的其它机构，使得蠕动泵管能够通过 弹簧构件，通过蠕动泵并且通过安装在所述蠕动泵的相对侧上的类似薄的凹入弹簧构件中的凹口，使得弹簧构件防止管的拉伸或变形。 许多其他实施例是可能的。 所有这些实施例允许将第一和第二缺口弹簧夹或其它管夹固定在蠕动泵框的输入和输出侧上; 穿过蠕动泵管通过第一弹簧夹或管夹持器中的凹口或其它部分穿过蠕动泵，并穿过第二弹簧夹或管夹中的凹口或其它部分。

公开(公告)号：US20080142961A1

公开(公告)日：2008-06-19

申请号：US11611063

申请日：2006-12-14

Applicant: Christopher C. Jones ,  David Bach ,  Timothe Litt ,  Larry Binder ,  Kaladhar Radhakrishnan ,  Cengiz A. Palanduz

Inventor： Christopher C. Jones ,  David Bach ,  Timothe Litt ,  Larry Binder ,  Kaladhar Radhakrishnan ,  Cengiz A. Palanduz

IPC: H01L23/34

CPC classification number: H05K1/0231 ,  H01L25/0655 ,  H01L25/165 ,  H01L2224/16225 ,  H01L2224/16227 ,  H01L2224/16265 ,  H01L2924/1515 ,  H01L2924/15153 ,  H01L2924/15311 ,  H01L2924/19041 ,  H01L2924/19103 ,  H01L2924/19105 ,  H01L2924/3011 ,  H05K1/145 ,  H05K1/183 ,  H05K2201/10515 ,  H05K2201/10712 ,  H05K2201/10734

Abstract: A ceramic package substrate has a recess. This allows a device in that recess to be close to a die attached to the substrate's top side, for better performance. The device may be an array capacitor, an in-silicon voltage regulator, or another device or devices.

Abstract translation: 陶瓷封装基板具有凹部。 这使得该凹部中的器件靠近附接到衬底顶侧的管芯，以获得更好的性能。 该器件可以是阵列电容器，硅内电压调节器或其它器件。

公开(公告)号：US20050006410A1

公开(公告)日：2005-01-13

申请号：US10848817

申请日：2004-05-19

Applicant: David Bach ,  Muniswamappa Anjanappa ,  Gayathri Ragavan ,  Tao Song

Inventor： David Bach ,  Muniswamappa Anjanappa ,  Gayathri Ragavan ,  Tao Song

IPC: B01F5/12 ,  B01L3/02 ,  F04B7/04 ,  F04B13/00 ,  G01F11/06

CPC classification number: B01L3/0206 ,  B01F5/12 ,  B01L3/0227 ,  B01L2400/0622 ,  F04B7/04 ,  F04B13/00

Abstract: A precision fluid dispensing system containing at least one two-piece pump and a precision closed loop controller drive system to address the small volume precision dispensing requirements of bioscience applications. A multiple diameter pump can be combined with a pump having multiple inlet and outlet ports to allow for precision multiple outlet dispenses in a single pump that finds use with microtiter plate pipetting and other precision dispensing. Inlet ports can be located on the smaller diameter of the cylinder with outlet ports on the larger diameter of the cylinder. A microcontroller with closed loop feedback provides exact linear positioning and motion of the pump piston as well as optional control of a nozzle to provide exact micro-dispensing of fluids. A dual piston pump can be used to provide greater accuracy.

Abstract translation: 精密流体分配系统，包含至少一个两件式泵和精密闭环控制器驱动系统，以解决生物科学应用的小体积精密分配要求。 多直径泵可以与具有多个入口和出口的泵组合，以允许精确的多个出口分配在单个泵中，其可用于微量滴定板移液和其它精确分配。 入口端口可以位于气缸的较小直径上，出口端口在气缸的较大直径上。 具有闭环反馈的微控制器提供泵活塞的精确线性定位和运动，以及可选择地控制喷嘴以提供精确的微分配流体。 双活塞泵可用于提供更高的精度。