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    SYSTEMS AND METHODS FOR ACTIVE BIOFOULING CONTROL
    3.
    发明申请
    SYSTEMS AND METHODS FOR ACTIVE BIOFOULING CONTROL 审中-公开
    用于主动生物控制的系统和方法

    公开(公告)号：US20140230854A1

    公开(公告)日：2014-08-21

    申请号：US14347672

    申请日：2012-09-28

    Applicant: DUKE UNIVERSITY

    Inventor： Gabriel P. Lopez ,  Vrad W. Levering ,  Xuanhe Zhao ,  Phanindhar Shivapooja ,  Qiming Wang

    IPC: B08B7/02

    CPC classification number: B08B7/02 ,  A01N25/34 ,  A61M25/0017 ,  A61M25/0023 ,  A61M2025/0019 ,  A61M2025/0024 ,  A61M2025/0025 ,  B08B17/06

    Abstract: Disclosed herein are devices and methods for active biofouling control. According to an aspect, a device comprising a surface for contacting a biological material. The device also comprises a mechanism comprising a structure configured to change the surface between a first shape and a second shape. The change from the first shape to the second shape deforms the surface beyond a critical strain for debonding of a fouling agent from the surface when the fouling agent has bonded to the surface in the first shape.

    Abstract translation: 本文公开了用于主动生物污垢控制的装置和方法。 根据一方面，一种包括用于接触生物材料的表面的装置。 该装置还包括一种机构，其包括构造成在第一形状和第二形状之间改变表面的结构。 当第一形状到第二形状的变化使得当污垢结合到第一形状的表面时，表面超过用于从表面剥离污垢剂的临界应变。

    CATHETERS FOR DEBONDING FOULING AGENTS FROM AN INTERIOR SURFACE THEREOF AND RELATED METHODS
    4.
    发明申请
    CATHETERS FOR DEBONDING FOULING AGENTS FROM AN INTERIOR SURFACE THEREOF AND RELATED METHODS 审中-公开

    公开(公告)号：US20180289924A1

    公开(公告)日：2018-10-11

    申请号：US15769592

    申请日：2016-10-28

    Applicant: Duke University

    Inventor： Vrad W. Levering ,  Changyong Cao ,  Gabriel P. Lopez ,  Xuanhe Zhao ,  Howard Levinson

    IPC: A61M25/00

    Abstract: Catheters for debonding fouling agents from an interior surface thereof and related methods are disclosed. According to an aspect, a catheter includes a lumen defining a flexible, interior surface that extends substantially along a length of the lumen for contacting a biological material. The catheter also includes cavities extending along the length and positioned within the lumen adjacent to the surface. The cavities each define a cavity opening. The catheter also includes an inflation hub defining hub openings connected to respective cavity openings. The inflation hub defines a pump port configured to interface with a pump. The inflation hub defines one or more fluid pathways that extend between the hub openings and the pump port for permitting flow of gas between the pump and the cavities.

    Disposable pipette tip and methods of use
    5.
    发明授权
    Disposable pipette tip and methods of use 有权

    公开(公告)号：US10016756B2

    公开(公告)日：2018-07-10

    申请号：US15466998

    申请日：2017-03-23

    Applicant: Duke University

    Inventor： Gabriel P. Lopez

    IPC: B01L3/00 ,  B01L3/02 ,  G01N1/40

    CPC classification number: B01L3/0275 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2400/0433 ,  G01N1/4077 ,  G01N2001/4094 ,  G01N2015/1006 ,  G01N2035/1048

    Abstract: A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid. The kit may also include a vibratory device in communication with the acoustic channel and configured for imparting a vibratory force thereto. The impartation of the vibratory force may create standing acoustic waves, thereby separating any negative acoustic contrast particles (NACPs) from the remaining contents of the liquid sample. The NACPs may capable of biospecific recognition of the analyte of interest, thereby separating the analytes of interest, which can then be collected or analyzed accordingly.

    Compositions, systems and methods for the encapsulation and delivery of a substance
    7.
    发明授权
    Compositions, systems and methods for the encapsulation and delivery of a substance 有权

    公开(公告)号：US10238586B2

    公开(公告)日：2019-03-26

    申请号：US15492786

    申请日：2017-04-20

    Applicant: Duke University

    Inventor： Charles W. Shields, IV ,  Gabriel P. Lopez ,  Nick Kirby

    IPC: A61K8/11 ,  A61K8/892 ,  A61Q19/08 ,  A61K8/34 ,  A61K8/891 ,  A61Q19/00 ,  A61K8/67 ,  A61K8/893

    Abstract: A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having two, three or four siloxane bonds in an acidic aqueous solution under conditions sufficient to allow for hydrolysis of the monomers, adding a catalyst and a solution comprising a co-solvent and the active ingredient(s) to the acidic aqueous solution, and continuing to agitate the combined solution to allow for a condensation reaction and formation of silicone particles with a narrow size distribution encapsulating at least a portion of the active ingredient(s). The tunable degree of crosslink density of the particles formed is based on the ratios of the monomers used, which enables controlled release of the active ingredient(s) from the particles.

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