公开(公告)号：US11583819B2

公开(公告)日：2023-02-21

申请号：US16817299

申请日：2020-03-12

Applicant: Duke University ,  UNM Rainforest Innovations

Inventor： Gabriel P. Lopez ,  Joseph R. Simon ,  Nick J. Carroll ,  Ashutosh Chilkoti

IPC: A61K9/14 ,  B01J2/00 ,  C07K14/78 ,  A61L31/16 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C12M1/00 ,  B01J13/06 ,  C07K19/00 ,  A61K38/00 ,  B01J2/06 ,  A61L27/54

Abstract: Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.

公开(公告)号：US20160271262A1

公开(公告)日：2016-09-22

申请号：US15074132

申请日：2016-03-18

Applicant: Duke University

Inventor： Gabriel P. Lopez ,  Ashutosh Chilkoti ,  Ali Ghoorchian ,  Joseph R. Simon

IPC: A61K47/48 ,  A61K9/06

CPC classification number: A61K47/64 ,  A61K9/06 ,  A61K47/6907 ,  A61L27/227 ,  A61L27/52 ,  A61L2300/252 ,  A61L2300/626 ,  C07K14/78 ,  C08J3/075 ,  C08J2389/00

Abstract: The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.

Abstract translation: 目前公开的主题涉及包含其的组合物，方法和系统（例如，平台），所述系统包含由多肽胶束形成的微水凝胶和大水凝胶，或由其组成。 这些系统具有增强的机械性能，其可用于各种应用中，可用于控制释放载药胶束，并且可以设计成可按要求可逆地组装和拆卸。

公开(公告)号：US09956300B2

公开(公告)日：2018-05-01

申请号：US15074132

申请日：2016-03-18

Applicant: Duke University

Inventor： Gabriel P. Lopez ,  Ashutosh Chilkoti ,  Ali Ghoorchian ,  Joseph R. Simon

IPC: A61K47/00 ,  C07K14/00 ,  A61K47/48 ,  A61K9/06 ,  C08J3/075 ,  A61L27/22 ,  A61L27/52 ,  C07K14/78 ,  A61K47/64 ,  A61K47/69

CPC classification number: A61K47/64 ,  A61K9/06 ,  A61K47/6907 ,  A61L27/227 ,  A61L27/52 ,  A61L2300/252 ,  A61L2300/626 ,  C07K14/78 ,  C08J3/075 ,  C08J2389/00

Abstract: The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.

公开(公告)号：US20170216808A1

公开(公告)日：2017-08-03

申请号：US15487543

申请日：2017-04-14

Applicant: Duke University

Inventor： Gabriel P. Lopez ,  Joseph R. Simon ,  Nick J. Carroll ,  Ashutosh Chilkoti

IPC: B01J13/06 ,  C12M1/00 ,  A61L31/10 ,  A61L29/08 ,  A61K9/14 ,  A61L27/34

CPC classification number: B01J13/06 ,  A61K9/146 ,  A61K38/39 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/62 ,  B01J2/00 ,  B01J2/06 ,  C07K14/78 ,  C07K19/00 ,  C12M23/20

Abstract: Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.