公开(公告)号：US09966243B2

公开(公告)日：2018-05-08

申请号：US14764047

申请日：2014-01-28

Applicant: GEORGETOWN UNIVERSITY

Inventor： Kaveh Jorabchi ,  Haopeng Wang

IPC: G01N30/90 ,  H01J49/00 ,  H01J49/10 ,  H01J49/14 ,  G01N30/72 ,  H01J49/04

CPC classification number: H01J49/0031 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/04 ,  H01J49/105 ,  H01J49/145

Abstract: Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (CRI) containing reactant gas plasma and an ionization chamber that is downstream from the CRI. The ionization chamber facilitates formation of ions from element-specific products of the CRI by an electron source or an ionization gas. In particular, PARCI provides a method for conducting highly sensitive mass spectrometric elemental analysis of analyte compounds with high ionization potential elements; for example, fluorine, chlorine, and bromine.

公开(公告)号：US20160013037A1

公开(公告)日：2016-01-14

申请号：US14764047

申请日：2014-01-28

Applicant: GEORGETOWN UNIVERSITY

Inventor： Kaveh Jorabchi ,  Haopeng Wang

IPC: H01J49/00 ,  H01J49/04 ,  G01N30/72

CPC classification number: H01J49/0031 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/04 ,  H01J49/105 ,  H01J49/145

Abstract: Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (CRI) containing reactant gas plasma and an ionization chamber that is downstream from the CRI. The ionization chamber facilitates formation of ions from element-specific products of the CRI by an electron source or an ionization gas. In particular, PARCI provides a method for conducting highly sensitive mass spectrometric elemental analysis of analyte compounds with high ionization potential elements; for example, fluorine, chlorine, and bromine.

Abstract translation: 等离子体辅助反应化学电离（PARCI）通过产生带正电荷和带负电荷的离子提供高度敏感的元素分析。 本申请中描述的PARCI装置，试剂盒和方法涉及包含含有反应物气体等离子体的化学反应界面（CRI）和在CRI下游的电离室的系统。 电离室有助于通过电子源或电离气体从CRI的元素特异性产物形成离子。 特别地，PARCI提供了用于对具有高电离电位元素的分析物化合物进行高灵敏度质谱元素分析的方法; 例如氟，氯和溴。