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    Methods and Compositions for Sequencing Nucleic Acids Using Charge
    1.
    发明申请
    Methods and Compositions for Sequencing Nucleic Acids Using Charge 有权
    使用电荷测序核酸的方法和组合

    公开(公告)号：US20160222446A1

    公开(公告)日：2016-08-04

    申请号：US15095560

    申请日：2016-04-11

    Applicant: Intelligent Bio-Systems, Inc.

    Inventor： Steven Gordon ,  Jerzy Olejnik

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12Q2525/117 ,  C12Q2565/30

    Abstract: The invention provides methods and compositions, and systems for determining the identity of nucleic acids in nucleotide sequences, including sequences with one or more homopolymer regions. The methods of the invention include improvements so as to accurately identify sequences, including the difficult homopolymer sequences that are encountered during nucleotide sequencing, such as pyrosequencing.

    Abstract translation: 本发明提供了用于确定核苷酸序列中核酸的同一性的方法和组合物以及系统，包括具有一个或多个均聚物区域的序列。 本发明的方法包括改进以便准确地鉴定序列，包括在核苷酸测序期间遇到的困难的均聚物序列，如焦磷酸测序。

    Sample Preparation
    3.
    发明申请
    Sample Preparation 审中-公开
    样品制备

    公开(公告)号：US20140342363A1

    公开(公告)日：2014-11-20

    申请号：US13898064

    申请日：2013-05-20

    Applicant: Intelligent Bio-Systems, Inc.

    Inventor： Steven Gordon ,  Phillip A. Veatch

    IPC: C12Q1/68

    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

    Abstract translation: 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。 这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。

    Methods and compositions for incorporating nucleotides
    4.
    发明授权
    Methods and compositions for incorporating nucleotides 有权

    公开(公告)号：US10329611B2

    公开(公告)日：2019-06-25

    申请号：US15911801

    申请日：2018-03-05

    Applicant: INTELLIGENT BIO-SYSTEMS, INC.

    Inventor： Steven Gordon ,  Jerzy Olejnik

    IPC: C12Q1/68 ,  C12Q1/6869 ,  C07H19/00 ,  G01N21/05 ,  G01N21/64 ,  C12Q1/6874 ,  G01N21/03

    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

    Analyte Enrichment Methods And Compositions
    7.
    发明申请
    Analyte Enrichment Methods And Compositions 审中-公开
    分析物富集方法和组成

    公开(公告)号：US20140335528A1

    公开(公告)日：2014-11-13

    申请号：US14264758

    申请日：2014-04-29

    Applicant: Intelligent Bio-Systems, Inc

    Inventor： Jerzy Olejnik ,  Steven Gordon ,  Martina Werner

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C12Q1/6844 ,  C12Q2537/159 ,  C12Q2563/131 ,  C12Q2563/149 ,  C12Q2563/159

    Abstract: Methods and compositions for enriching a population of particles containing an analyte are disclosed. In one embodiment, enrichment beads are used that are larger in size than the beads used for amplification. A separation device is employed that can retain larger beads with bound amplified beads. The technique finds many uses, including enriching for beads with clonally amplified template, which can be used in a variety of assays, including nucleic acid sequencing.

    Abstract translation: 公开了用于富集含有分析物的颗粒群的方法和组合物。 在一个实施方案中，使用比用于扩增的珠更大的富集珠。 使用分离装置，其可以用结合的扩增珠粒保留较大的珠粒。 该技术发现许多用途，包括用克隆扩增模板富集珠，可用于多种测定，包括核酸测序。

    Methods And Solutions For Inhibiting Undesired Cleaving Of Labels
    9.
    发明申请
    Methods And Solutions For Inhibiting Undesired Cleaving Of Labels 有权
    抑制不必要的烙印标签的方法和解决方案

    公开(公告)号：US20150099647A1

    公开(公告)日：2015-04-09

    申请号：US14456321

    申请日：2014-08-11

    Applicant: Intelligent Bio-Systems, Inc.

    Inventor： Steven Gordon ,  Phillip A. Veatch

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6825 ,  G06F19/20 ,  C12Q2527/137 ,  C12Q2525/186 ,  C12Q2525/117 ,  C12Q2565/601 ,  C12Q2563/107 ,  C12Q2537/165

    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

    Abstract translation: 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。 这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。

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