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    Polyether Polymer Matrix
    1.
    发明申请
    Polyether Polymer Matrix 审中-公开
    聚醚聚合物基质

    公开(公告)号：US20080213568A1

    公开(公告)日：2008-09-04

    申请号：US11661341

    申请日：2005-08-26

    Applicant: Ib Johannsen ,  Patrik Gavelin ,  Monica R. Gallego

    Inventor： Ib Johannsen ,  Patrik Gavelin ,  Monica R. Gallego

    IPC: C08G65/18 ,  C08G65/02 ,  C08F287/00 ,  B32B5/16

    CPC classification number: C08G65/18 ,  C08G65/00 ,  Y10T428/254

    Abstract: The present invention relates to polyether resins, methods for their manufacture and uses thereof. In one aspect of the invention the polyether resin comprises a plurality of functional groups and is obtained by polymerisation of a mixture of alkoxylated reactive compounds selected from a) alkoxylated compounds having a functionality of more than one, and b) alkoxylated monofunctional reactive compounds, wherein the alkoxylated part of the alkoxylated compounds having a functionality of more than one has an average molecular weight which is different from the average molecular weight of the alkoxylated part of the alkoxylated monofunctional reactive compounds.

    Abstract translation: 本发明涉及聚醚树脂，其制造方法和用途。 在本发明的一个方面，聚醚树脂包括多个官能团，并且通过选自以下的烷氧基化反应性化合物的混合物聚合得到：a）具有多于一个官能度的烷氧基化化合物，和b）烷氧基化单官能反应性化合物，其中 具有多于一个官能度的烷氧基化化合物的烷氧基化部分具有与烷氧基化单官能反应性化合物的烷氧基化部分的平均分子量不同的平均分子量。

    Spatially encoded polymer matrix
    3.
    发明授权
    Spatially encoded polymer matrix 有权
    空间编码聚合物基质

    公开(公告)号：US08791053B2

    公开(公告)日：2014-07-29

    申请号：US10529397

    申请日：2003-09-26

    Applicant: Soren Flygenring Christensen ,  Jens Hog Truelsen ,  Morten Meldal ,  Roice Michael ,  Ib Johannsen

    Inventor： Soren Flygenring Christensen ,  Jens Hog Truelsen ,  Morten Meldal ,  Roice Michael ,  Ib Johannsen

    IPC: C40B40/00 ,  C40B40/04 ,  C40B40/18 ,  C40B30/10 ,  C40B20/04 ,  C40B20/08 ,  B01J19/00

    CPC classification number: B01J19/0046 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00551 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/0074

    Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilized particles. The spatial immobilization of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.

    Abstract translation: 本发明涉及用于组合固相合成，测定，功能蛋白质组学和诊断用途的珠粒或颗粒形式的空间编码聚合物基质。 还提供了这种珠粒或颗粒的组合物。 组合物的每个串珠聚合物基质包含多个空间固定的颗粒。 颗粒的空间固定赋予每个珠光聚合物基质上的“指纹”，其使得能够鉴定珠粒群体中独特的珠粒。 单个珠的独特鉴定使得在记录单个化学转化的同时执行组合化学策略成为可能。 还提供了用于检测颗粒空间中的相对位置的方法，用于生成矩阵的方法，用于距离矩阵确定的方法，用于识别各个矩阵的方法以及用于记录和存储矩阵的图像的设备。

    Method of providing a hydrophobic layer and condenser microphone having such a layer
    4.
    再颁专利
    Method of providing a hydrophobic layer and condenser microphone having such a layer 有权
    提供具有这种层的疏水层和电容式麦克风的方法

    公开(公告)号：USRE40781E1

    公开(公告)日：2009-06-23

    申请号：US11502577

    申请日：2006-08-10

    Applicant: Ib Johannsen ,  Niels Bent Larsen ,  Matthias Mullenborn ,  Pirmin Hermann Otto Rombach

    Inventor： Ib Johannsen ,  Niels Bent Larsen ,  Matthias Mullenborn ,  Pirmin Hermann Otto Rombach

    IPC: H04R25/00

    CPC classification number: B82Y30/00 ,  H04R19/005 ,  H04R19/04 ,  H04R31/00

    Abstract: A method of providing at least part of a diaphragm and at least a part of a back-plate of a condenser microphone with a hydrophobic layer so as to avoid stiction between said diaphragm and said back-plate. The layer is deposited via a number small of openings in the back-plate, the diaphragm and/or between the diaphragm and the back-plate. Provides a homogeneous and structured hydrophobic layer, even to small internal cavities of the microstructure. The layer may be deposited by a liquid phase or a vapor phase deposition method. The method may be applied naturally in continuation of the normal manufacturing process.Further, a MEMS condenser microphone is provided having such a hydrophobic layer. The static distance between the diaphragm and the back-plate of the microphone is smaller than 10 μm.

    Abstract translation: 提供具有疏水层的隔膜的至少一部分和电容式传声器的背板的至少一部分的方法，以避免所述隔膜和所述背板之间的粘连。 该层通过背板，隔膜和/或隔膜和背板之间的数个小的开口沉积。 提供均匀和结构化的疏水层，即使是微结构的小内腔。 该层可以通过液相或气相沉积方法沉积。 该方法可以自然地应用于正常制造过程的继续。 此外，提供具有这样的疏水层的MEMS电容式麦克风。 隔膜与麦克风背板之间的静态距离小于10 mum。

    Apparatus and methods for analysis and sorting of particles such as polymer beads
    5.
    发明申请
    Apparatus and methods for analysis and sorting of particles such as polymer beads 有权
    用于分析和分选诸如聚合物珠粒子的装置和方法

    公开(公告)号：US20090025489A1

    公开(公告)日：2009-01-29

    申请号：US10583997

    申请日：2004-12-22

    Applicant: Soeren Flygenring Christensen ,  Ib Johannsen

    Inventor： Soeren Flygenring Christensen ,  Ib Johannsen

    IPC: G01N1/00

    CPC classification number: G01N21/645 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00551 ,  C40B70/00 ,  G01N2015/149 ,  G01N2021/6417 ,  G01N2035/00574

    Abstract: The present invention relates to an apparatus for analysing beads and particles, such as polymer beads used e.g. for solid phase synthesis. The apparatus in one embodiment comprises a rotatable, circular disc comprising a plurality of through-going inlets, wherein an individual bead from a composition comprising different beads can be fixed to the disc at the end-position of a through-going inlet by applying a pressure drop over said disc comprising said through-going inlets. The pressure drop results in beads being sucked (i.e. detachably fixed) onto the disc on top of the through-going inlets. When the disc is rotated the beads are transferred from the position where they initially became attached to the disc to fixed positions wherein suitable devices for measuring and/or analysing and/or sorting the beads can be operated in order to e.g. measure and/or analyse and/or sort at least one bead of a plurality of beads. More specifically, the invention relates to an apparatus for measuring a plurality of optically detectable beads, such as polymer beads, said apparatus comprising a) a vacuum container comprising at least one planar capture body capable of rotating around a central axis, wherein said capture body comprises a plurality of through-going inlets, and wherein the diameter of each inlet is smaller than the average diameter of the beads to be measured and/or analysed and/or sorted, b) a pressure controlling device capable of controlling the pressure in the vacuum container, c) a device for rotating the vacuum container around the axis of the capture disc, and d) a device for measuring at least one property of at least one bead.

    Abstract translation: 本发明涉及一种用于分析珠粒和颗粒的装置，例如聚合物珠，例如聚合物珠。 用于固相合成。 在一个实施例中的装置包括可旋转的圆盘，其包括多个贯穿入口，其中来自包含不同珠粒的组合物的单个珠粒可以在通入入口的终端位置处固定到盘上， 所述盘上的压降包括所述贯穿入口。 压力下降导致珠被吸入（即可拆卸地固定）到贯穿入口的顶部上的盘上。 当盘旋转时，珠粒从它们最初附着到盘的位置转移到固定位置，其中用于测量和/或分析和/或分选珠粒的合适的装置可以操作以便例如 测量和/或分析和/或排列多个珠粒的至少一个珠粒。 更具体地，本发明涉及一种用于测量多个可光学检测的珠粒（例如聚合物珠粒）的装置，所述装置包括：a）真空容器，其包括能够围绕中心轴线旋转的至少一个平面捕获体，其中所述捕获体 包括多个贯通入口，并且其中每个入口的直径小于待测量和/或分析和/或分选的珠粒的平均直径; b）压力控制装置，其能够控制在 真空容器，c）用于围绕捕获盘的轴线旋转真空容器的装置，以及d）用于测量至少一个珠粒的至少一个性质的装置。

    Method of modifying a macromolecular system
    6.
    发明授权
    Method of modifying a macromolecular system 失效
    改性大分子体系的方法

    公开(公告)号：US07897698B2

    公开(公告)日：2011-03-01

    申请号：US11990455

    申请日：2006-08-25

    Applicant: Ib Johannsen ,  Roice Michael

    Inventor： Ib Johannsen ,  Roice Michael

    IPC: C08L71/02

    CPC classification number: C08G65/2618 ,  C08G65/331

    Abstract: The present application discloses a method of modifying a macromolecule, the method comprising the steps of (i) providing the macromolecule; (ii) providing a compound of the general formula (I): wherein N is a primary amino group protected with the protecting group P, wherein the protecting group involves both free valences of the primary amino group; m is an integer of 1-12 and n is an integer of 1-2000; R1 and R2 are independently selected from the group consisting of hydrogen and C1-4-alkyl; and X is a reactive group; and (iii) allowing the compound of the general formula (I) to react with the macromolecule so as to form grafts on the macromolecule. Compounds of the general formula (i) and a method for the preparation thereof are also disclosed.

    Abstract translation: 本申请公开了一种修饰大分子的方法，该方法包括以下步骤：（i）提供大分子; （ii）提供通式（I）的化合物：其中N是被保护基P保护的伯氨基，其中保护基包括伯氨基的游离价; m为1-12的整数，n为1-2000的整数; R 1和R 2独立地选自氢和C 1-4 - 烷基; X为反应性基团; 和（iii）使通式（I）的化合物与大分子反应，以便在大分子上形成移植物。 还公开了通式（i）的化合物及其制备方法。

    Apparatus and methods for analysis and sorting of particles such as polymer beads
    7.
    发明授权
    Apparatus and methods for analysis and sorting of particles such as polymer beads 有权
    用于分析和分选诸如聚合物珠粒子的装置和方法

    公开(公告)号：US07869011B2

    公开(公告)日：2011-01-11

    申请号：US10583997

    申请日：2004-12-22

    Applicant: Soeren Flygenring Christensen ,  Ib Johannsen

    Inventor： Soeren Flygenring Christensen ,  Ib Johannsen

    IPC: G01J3/44

    CPC classification number: G01N21/645 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00551 ,  C40B70/00 ,  G01N2015/149 ,  G01N2021/6417 ,  G01N2035/00574

    Abstract: The present invention relates to an apparatus for analysing beads and particles, such as polymer beads used e.g. for solid phase synthesis. The apparatus comprises a) a vacuum container comprising at least one planar capture body capable of rotating around a central axis, wherein said capture body comprises a plurality of through-going inlets, and wherein the diameter of each inlet is smaller than the average diameter of the beads to be measured and/or analysed and/or sorted, b) a pressure controlling device capable of controlling the pressure in the vacuum container, c) a device for rotating the vacuum container around the axis of the capture body, and d) a device for measuring at least one property of at least one bead, the apparatus further comprising a capture body support, supporting the capture body, and a vacuum container housing.

    Abstract translation: 本发明涉及一种用于分析珠粒和颗粒的装置，例如聚合物珠，例如聚合物珠。 用于固相合成。 该设备包括：a）真空容器，其包括能够围绕中心轴线旋转的至少一个平面捕获体，其中所述捕获体包括多个通入入口，并且其中每个入口的直径小于 要测量和/或分析和/或分类的珠粒，b）能够控制真空容器中的压力的​​压力控制装置，c）围绕捕获体的轴线旋转真空容器的装置，以及d） 用于测量至少一个珠粒的至少一个性质的装置，所述装置还包括捕获体支撑件，支撑捕获体和真空容器壳体。

    Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof
    9.
    发明申请
    Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof 审中-公开
    串联和交联聚（氨基亚烷基）基体及其用途

    公开(公告)号：US20090023606A1

    公开(公告)日：2009-01-22

    申请号：US11659863

    申请日：2005-06-10

    Applicant: Patrik Gavelin ,  Nicola Pehr-Rehnberg ,  Ib Johannsen

    Inventor： Patrik Gavelin ,  Nicola Pehr-Rehnberg ,  Ib Johannsen

    IPC: C08F226/02 ,  C40B50/14 ,  C07K1/00 ,  C07K1/04 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C08F226/02 ,  B01J20/267 ,  B01J20/285 ,  C08J3/12 ,  C08J3/246 ,  C08J2339/02 ,  C08J2371/02

    Abstract: The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≧2.

    Abstract translation: 本发明涉及用于固相合成，反应混合物纯化，色谱分离步骤等的串联和交联的高负载能力聚合物的合成。 因此，本发明可用于分离对聚合物珠粒或与其连接的化学实体具有亲和力的分子实体。 串珠聚合物基质可以通过在反相悬浮或反相乳液聚合条件下与官能度> = 2的交联单元交联任选取代的聚（氨基亚烷基）而形成。

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