公开(公告)号：US20220204459A1

公开(公告)日：2022-06-30

申请号：US17557751

申请日：2021-12-21

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Masaki Takiwaki ,  Seketsu Fukuzawa

IPC: C07D249/12

Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

公开(公告)号：US11946910B2

公开(公告)日：2024-04-02

申请号：US16973306

申请日：2019-06-11

Applicant: TOKUYAMA CORPORATION ,  JEOL Ltd.

Inventor： Masahiko Seki ,  Seketsu Fukuzawa ,  Masaki Takiwaki

IPC: G01N30/06 ,  C07D487/08 ,  G01N33/82

CPC classification number: G01N30/06 ,  C07D487/08 ,  G01N33/82 ,  G01N2030/067

Abstract: Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.)

公开(公告)号：US11927510B2

公开(公告)日：2024-03-12

申请号：US16953502

申请日：2020-11-20

Applicant: JEOL Ltd.

Inventor： Masaki Takiwaki ,  Seketsu Fukuzawa ,  Yoshikuni Kikutani ,  Kiyotaka Fujino ,  Kentaro Abe ,  Yoshiyuki Ito

IPC: G01N1/28 ,  G01N33/74 ,  G01N33/82

CPC classification number: G01N1/28 ,  G01N33/743 ,  G01N33/82 ,  G01N2001/2893 ,  Y10T436/104165

Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.

公开(公告)号：US11718590B2

公开(公告)日：2023-08-08

申请号：US17557751

申请日：2021-12-21

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Masaki Takiwaki ,  Seketsu Fukuzawa

IPC: C07D249/12

CPC classification number: C07D249/12

Abstract: A compound represented by Chemical formula 1:




wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

公开(公告)号：US20230112623A1

公开(公告)日：2023-04-13

申请号：US17961020

申请日：2022-10-06

Applicant: JEOL Ltd.

Inventor： Seketsu Fukuzawa ,  Koji Takahashi ,  Yoshiyuki Itoh ,  Masaki Takiwaki ,  Shugo Tsuda ,  Masayoshi Mochizuki ,  Taku Yoshiya

IPC: C07F9/54

Abstract: Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y− is an anion having a total charge of −1, or Y− is absence.

公开(公告)号：US20220288558A1

公开(公告)日：2022-09-15

申请号：US17689389

申请日：2022-03-08

Applicant: JEOL Ltd.

Inventor： Seketsu Fukuzawa ,  Koji Takahashi

IPC: B01J20/14 ,  G01N33/82 ,  B01J20/285 ,  B01J20/283 ,  B01J20/26 ,  B01J20/06 ,  B01J20/28 ,  B01D15/20

Abstract: Provided is a solid phase mixture including an oxidizing agent and/or a salt of the oxidizing agent and solid phase particles. The oxidizing agent is a compound capable of selectively oxidizing 1,2-diol compounds. In addition, a packing material containing the solid phase mixture is provided. Further, a column packed with the packing material is provided.

公开(公告)号：US12291546B2

公开(公告)日：2025-05-06

申请号：US17961020

申请日：2022-10-06

Applicant: JEOL Ltd.

Inventor： Seketsu Fukuzawa ,  Koji Takahashi ,  Yoshiyuki Itoh ,  Masaki Takiwaki ,  Shugo Tsuda ,  Masayoshi Mochizuki ,  Taku Yoshiya

IPC: C07F9/54

Abstract: Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y− is an anion having a total charge of −1, or Y− is absence.

公开(公告)号：US20230242480A1

公开(公告)日：2023-08-03

申请号：US18087881

申请日：2022-12-23

Applicant: Tokyo University of Agriculture and Technology ,  JEOL Ltd.

Inventor： Akiko Nagata ,  Yuka Mizumoto ,  Ryota Sakamoto ,  Kazuo Nagasawa ,  Masaki Takiwaki ,  Yoshikuni Kikutani ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC: C07C401/00 ,  G01N30/72 ,  C07F7/18

CPC classification number: C07C401/00 ,  G01N30/72 ,  C07F7/1804 ,  G01N2030/027

Abstract: The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):




where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

公开(公告)号：US11339133B2

公开(公告)日：2022-05-24

申请号：US16973216

申请日：2019-06-11

Applicant: TOKUYAMA CORPORATION ,  JEOL Ltd.

Inventor： Makoto Satou ,  Misao Matsushige ,  Seketsu Fukuzawa ,  Masaki Takiwaki

IPC: C07D249/12

Abstract: Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, R1 is a substituted or unsubstituted amino group-bearing organic group.)

公开(公告)号：US20210156770A1

公开(公告)日：2021-05-27

申请号：US16953502

申请日：2020-11-20

Applicant: JEOL Ltd.

Inventor： Masaki Takiwaki ,  Seketsu Fukuzawa ,  Yoshikuni Kikutani ,  Kiyotaka Fujino ,  Kentaro Abe ,  Yoshiyuki Ito

IPC: G01N1/28

Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.