公开(公告)号：US09978573B2

公开(公告)日：2018-05-22

申请号：US15552918

申请日：2016-03-15

Applicant: KEIO UNIVERSITY

Inventor： Tomoyoshi Soga ,  Akiyoshi Hirayama ,  Hiroshi Abe

IPC: H01J49/00 ,  H01J49/04 ,  G01N27/447 ,  B01D61/42

CPC classification number: H01J49/045 ,  B01D61/422 ,  G01N27/4473 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0404 ,  H01J49/165

Abstract: Processing a capillary distal end into acute-angle, an electrophoretic liquid passing hole through which electrophoretic liquid pass is opened in a flexible insulating plate. An electrodialysis-membrane is bonded covering the electrophoretic liquid passing hole; the capillary is securely bonded to the insulating plate portion with no gap therebetween, the portion excluding electrophoretic liquid passing hole on the electrodialysis top-membrane. A crack forms at the capillary portion at the electrophoretic liquid passing hole, with the capillary entirely secured to the insulating plate except portion at the electrophoretic liquid passing hole. The capillary is securely bonded to the insulating plate; reservoir stores electrophoretic liquid on the insulating plate-side to which the capillary is unsecured. An electrode insertion hole into which an electrode is inserted opened in the reservoir upper portion; the electrode is securely inserted into the electrode insertion hole. By this, high-sensitivity measurement is using a spray device for sheathless CE-MS.