公开(公告)号：US11833524B2

公开(公告)日：2023-12-05

申请号：US16621908

申请日：2018-06-13

Applicant: LAB-ON-A-BEAD AB

Inventor： Sven Oscarsson ,  Per-Olof Eriksson ,  Kristofer Eriksson

IPC: B03C1/28 ,  B03C1/30 ,  G01N33/543 ,  G01N35/00 ,  B03C1/01 ,  B03C1/033

CPC classification number: B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C1/30 ,  G01N33/54326 ,  G01N35/0098 ,  B03C2201/18 ,  B03C2201/26

Abstract: There is disclosed a combinatory separation system comprising: a first compartment adapted to handle a mixture with magnetic beads having an affinity for molecules, comprising a magnet to attract the beads, a second compartment adapted to receive said magnetic beads transferred thereto with a flow of liquid, and said at least one second compartment is adapted to elute said at least one type of molecules to be separated from said magnetic beads, said at least one second compartment has an outlet comprising means for retaining said magnetic beads in the at least one second compartment. Advantages include that the process becomes simpler quicker and thereby less expensive, since the method is able to remove cells and particles, separate molecules and perform virus inactivation in fewer steps compared to the prior art. Further the method is able to provide a more concentrated end product.

公开(公告)号：US10125199B2

公开(公告)日：2018-11-13

申请号：US15064661

申请日：2016-03-09

Applicant: Lab-on-a-bead AB

Inventor： Sven Oscarsson ,  Kristofer Eriksson ,  Peter Svedlindh

IPC: C08B37/00 ,  B01J20/32 ,  B01J20/285 ,  B01J20/28 ,  B01J20/286 ,  B01J20/24 ,  G01N33/543 ,  G01N33/548 ,  B01D15/38

Abstract: A method for the production of particles by reacting functional groups on the surface of non-magnetic porous particles with functional groups on the surface of magnetic particles to form a covalent bond, to obtain particles supplemented with magnetic particles covalently bound to the outer part of said particles. Advantages include an increased binding capacity.

公开(公告)号：US09777075B2

公开(公告)日：2017-10-03

申请号：US15064815

申请日：2016-03-09

Applicant: Lab-on-a-bead AB

Inventor： Sven Oscarsson ,  Kristofer Eriksson ,  Peter Svedlindh

IPC: G01N33/548 ,  C08B37/00 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  B01J20/28 ,  B01J20/24 ,  G01N33/543 ,  B01D15/38

CPC classification number: C08B37/0039 ,  B01D15/3804 ,  B01D15/3885 ,  B01J20/24 ,  B01J20/28009 ,  B01J20/28016 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3242 ,  B01J20/3265 ,  G01N33/5434 ,  G01N33/548

Abstract: A novel system for the analysis of molecules and cells, comprising clusters where a non-magnetic particle is supplemented with magnetic particles to form a characteristic pattern, fingerprint or bar code. Methods and devices for formation of such particles are also disclosed.