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    NEW PROCESS AND SYSTEM FOR MAGNETIC SEPARATION
    2.
    发明申请
    NEW PROCESS AND SYSTEM FOR MAGNETIC SEPARATION 审中-公开
    用于磁分离的新工艺和系统

    公开(公告)号：US20160184737A1

    公开(公告)日：2016-06-30

    申请号：US15064720

    申请日：2016-03-09

    Applicant: Lab-on-a-bead AB

    Inventor： Sven OSCARSSON ,  Kristofer ERIKSSON ,  Per-Olov ERIKSSON

    IPC: B01D15/38 ,  B01J20/282 ,  B01J20/28

    CPC classification number: B01D15/3885 ,  B01J20/28009 ,  B01J20/282 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274

    Abstract: A process for large scale separation of molecules comprising the steps of providing magnetic porous particles having an affinity to said molecules to be separated; mixing said magnetic porous particles with a solution containing said molecules; bringing said mixture in contact with a magnetic separation device comprising a flow channel and at least one magnetic element; removing said at least one magnetic element and collecting the magnetic porous particles carrying said molecules; separating said molecules from said magnetic porous particles; obtaining a concentrated fraction of said molecules; and recirculating the magnetic porous particles. A system for performing this process.

    Abstract translation: 一种用于大规模分离分子的方法，包括以下步骤：提供对待分离的分子具有亲和力的磁性多孔颗粒; 将所述磁性多孔颗粒与含有所述分子的溶液混合; 使所述混合物与包括流动通道和至少一个磁性元件的磁分离装置接触; 去除所述至少一个磁性元件并收集携带所述分子的磁性多孔颗粒; 将所述分子与所述磁性多孔颗粒分离; 获得所述分子的浓缩级分; 并再循环磁性多孔颗粒。 用于执行此过程的系统。

    Combinatory separation
    3.
    发明授权
    Combinatory separation 有权

    公开(公告)号：US11833524B2

    公开(公告)日：2023-12-05

    申请号：US16621908

    申请日：2018-06-13

    Applicant: LAB-ON-A-BEAD AB

    Inventor： Sven Oscarsson ,  Per-Olof Eriksson ,  Kristofer Eriksson

    IPC: B03C1/28 ,  B03C1/30 ,  G01N33/543 ,  G01N35/00 ,  B03C1/01 ,  B03C1/033

    CPC classification number: B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C1/30 ,  G01N33/54326 ,  G01N35/0098 ,  B03C2201/18 ,  B03C2201/26

    Abstract: There is disclosed a combinatory separation system comprising: a first compartment adapted to handle a mixture with magnetic beads having an affinity for molecules, comprising a magnet to attract the beads, a second compartment adapted to receive said magnetic beads transferred thereto with a flow of liquid, and said at least one second compartment is adapted to elute said at least one type of molecules to be separated from said magnetic beads, said at least one second compartment has an outlet comprising means for retaining said magnetic beads in the at least one second compartment. Advantages include that the process becomes simpler quicker and thereby less expensive, since the method is able to remove cells and particles, separate molecules and perform virus inactivation in fewer steps compared to the prior art. Further the method is able to provide a more concentrated end product.

    PURIFICATION PROCESS BASED ON MAGNETIC BEADS
    5.
    发明申请
    PURIFICATION PROCESS BASED ON MAGNETIC BEADS 有权

    公开(公告)号：US20220389053A1

    公开(公告)日：2022-12-08

    申请号：US17766366

    申请日：2020-10-05

    Applicant: LAB-ON-A-BEAD AB

    Inventor： Veronique CHOTTEAU ,  Kristofer ERIKSSON ,  Sven OSCARSSON ,  Nils Arnold BRECHMANN

    IPC: C07K1/22 ,  C12M1/00 ,  C12P21/02 ,  C12N13/00

    Abstract: There is provided a process for the separation of molecules from a suspension comprising cells at a concentration of at least 56×106 cells/ml, comprising the steps of: a) providing magnetic particles having a specific interaction with said molecules to be separated, b) mixing the magnetic particles with the cell suspension containing the molecules, c) bringing the cell suspension in contact with a magnetic field provided by a magnetic separation device to collect the magnetic particles, d) decreasing or removing said magnetic field and collecting said magnetic particles carrying said molecules, and e) removing said molecules from said magnetic particles, to provide a concentrated fraction of said molecules, and/or provide partial or complete removal of impurities and cells from the fraction containing the molecules. Advantages include that the yield increases, the volume of the bioreactor and other equipment can be made smaller so that the process becomes more economical.

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