公开(公告)号：US20160067462A1

公开(公告)日：2016-03-10

申请号：US14932033

申请日：2015-11-04

Applicant: Lutonix, Inc.

Inventor： Jeffrey Wang ,  Harrison Malinoff ,  Lixiao Wang ,  Christopher M. Barry ,  Dennis W. Wahr ,  Scott R. Naisbitt

IPC: A61M25/10 ,  B05D1/00 ,  B05D3/10 ,  B05D3/04 ,  B05D1/26

CPC classification number: A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1088 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0493 ,  B05D3/107 ,  B05D5/00

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

公开(公告)号：US09180485B2

公开(公告)日：2015-11-10

申请号：US13846358

申请日：2013-03-18

Applicant: Lutonix, Inc.

Inventor： Jeffrey Wang ,  Harrison Malinoff ,  Lixiao Wang ,  Christopher M. Barry ,  Dennis W. Wahr ,  Scott R. Naisbitt

IPC: B05D5/00 ,  B05D1/00 ,  B05D1/26 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1088 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0493 ,  B05D3/107 ,  B05D5/00

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

Abstract translation: 提供了用于涂覆医疗装置的方法和装置。 在一个实施方案中，制备基本上均匀的涂覆医疗装置的方法包括（1）制备包含溶剂，治疗剂和添加剂的包衣溶液; （2）用涂布液装载计量分配器; （3）围绕装置的纵向轴线旋转医疗装置和/或沿装置的纵向或横向轴线移动医疗装置; （4）将涂布溶液从计量分配器分配到医疗装置的表面上，并且在医疗装置旋转和/或线性移动时将涂布溶液流动到医疗装置的表面上; 和（5）蒸发溶剂，在医疗装置上形成基本上均匀的涂层。

公开(公告)号：US20210386917A1

公开(公告)日：2021-12-16

申请号：US17291806

申请日：2018-11-14

Applicant: Lutonix, Inc.

Inventor： Robert E. Burgmeier ,  Oleg Stanilevskiy ,  Jeffrey Wang

IPC: A61L29/14 ,  A61K31/337 ,  A61M25/00 ,  A61L29/08 ,  B05D3/14

Abstract: Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.

公开(公告)号：US09770576B2

公开(公告)日：2017-09-26

申请号：US14932033

申请日：2015-11-04

Applicant: Lutonix, Inc.

Inventor： Jeffrey Wang ,  Harrison Malinoff ,  Lixiao Wang ,  Christopher M. Barry ,  Dennis W. Wahr ,  Scott R. Naisbitt

IPC: A61M25/10 ,  B05D5/00 ,  B05D1/00 ,  B05D1/26 ,  B05D3/04 ,  B05D3/10

CPC classification number: A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1088 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0493 ,  B05D3/107 ,  B05D5/00

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

公开(公告)号：US20130209662A1

公开(公告)日：2013-08-15

申请号：US13846358

申请日：2013-03-18

Applicant: Lutonix, Inc.

Inventor： Jeffrey Wang ,  Harrison Malinoff ,  Lixiao Wang ,  Christopher M. Barry ,  Dennis W. Wahr ,  Scott R. Naisbitt

IPC: B05D5/00

CPC classification number: A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1088 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0493 ,  B05D3/107 ,  B05D5/00

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

Abstract translation: 提供了用于涂覆医疗装置的方法和装置。 在一个实施方案中，制备基本上均匀的涂覆医疗装置的方法包括（1）制备包含溶剂，治疗剂和添加剂的包衣溶液; （2）用涂布液装载计量分配器; （3）围绕装置的纵向轴线旋转医疗装置和/或沿装置的纵向或横向轴线移动医疗装置; （4）将涂布溶液从计量分配器分配到医疗装置的表面上，并且在医疗装置旋转和/或线性移动时将涂布溶液流动到医疗装置的表面上; 和（5）蒸发溶剂，在医疗装置上形成基本上均匀的涂层。

公开(公告)号：US11541152B2

公开(公告)日：2023-01-03

申请号：US17291806

申请日：2018-11-14

Applicant: Lutonix, Inc.

Inventor： Robert E. Burgmeier ,  Oleg Stanilevskiy ,  Jeffrey Wang

IPC: A61L29/14 ,  A61K31/337 ,  A61L29/08 ,  A61M25/00 ,  B05D3/14

Abstract: Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.