公开(公告)号：US11145497B2

公开(公告)日：2021-10-12

申请号：US16308214

申请日：2017-06-06

Applicant: Micromass UK Limited

Inventor： Steven Pringle ,  Emrys Jones ,  Mike Morris ,  Keith Richardson ,  Zoltan Takats

IPC: H01J49/00 ,  A61B5/00 ,  G01N21/71 ,  G01N27/622 ,  H01J49/16 ,  A61B1/313 ,  A61B18/00

Abstract: A method of analysing a target is disclosed comprising ablating a portion of a target so as to cause an aerosol plume to be produced and light or other electromagnetic radiation to be emitted. The aerosol plume is analysed using mass spectrometry and/or ion mobility spectrometry and the emitted light or other electromagnetic radiation is analysed using optical spectroscopy in order to determine one or more regions of interest of the target and/or one or more margins or bounds of a region of interest of the target.

公开(公告)号：US11031221B2

公开(公告)日：2021-06-08

申请号：US15555758

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US10777399B2

公开(公告)日：2020-09-15

申请号：US15764791

申请日：2016-09-22

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Lajos Godorhazy ,  Daniel Simon ,  Daniel Szalay ,  Zoltan Takats ,  Tamas Karancsi

IPC: H01J49/04 ,  G01N33/483 ,  G01N21/31 ,  G01N21/65

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.

公开(公告)号：US20150201913A1

公开(公告)日：2015-07-23

申请号：US14676720

申请日：2015-04-01

Applicant: Micromass UK Limited

Inventor： Zoltan Takats

IPC: A61B10/02 ,  H01J49/16

CPC classification number: A61B10/02 ,  G01N1/02 ,  G01N27/62 ,  G01N2001/028 ,  G01N2001/045 ,  G01N2001/2886 ,  H01J49/04 ,  H01J49/165 ,  H01J49/168

Abstract: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.

Abstract translation: 本发明提供了用于分析，定位和/或识别组织类型的系统，方法和装置。 该方法包括分析，定位和/或识别一个或多个组织样本，其特征在于，所述方法包括：（a）从所述一个或多个组织样品中的部位产生气体组织颗粒，（b）将气态组织颗粒从 （c）使用分析器基于气体组织颗粒产生组织相关数据，以及（d）基于组织相关数据分析，定位和/或识别所述一个或多个组织样本。 当一种或多种外科手术工具是电离的一体化部分时，本发明可以与外科手术紧密结合使用，或者作为用于分析一个或多个组织部分的单独的质谱探针。

公开(公告)号：US11367606B2

公开(公告)日：2022-06-21

申请号：US16544636

申请日：2019-08-19

Applicant: Micromass UK Limited

Inventor： Zoltan Takats ,  Emrys Jones ,  James Ian Langridge ,  Michael Raymond Morris ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Keith Richardson ,  Phillip Robert Bennett ,  David Alan MacIntyre ,  Pamela Pruski

IPC: H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US11367605B2

公开(公告)日：2022-06-21

申请号：US15555818

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Zoltan Takats

IPC: H01J49/04 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  G16B20/00 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

公开(公告)号：US11295941B2

公开(公告)日：2022-04-05

申请号：US15555818

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Zoltan Takats

IPC: H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

公开(公告)号：US11264223B2

公开(公告)日：2022-03-01

申请号：US16033447

申请日：2018-07-12

Applicant: Micromass UK Limited

Inventor： Zoltan Takats ,  Emrys Jones ,  James Ian Langridge ,  Michael Raymond Morris ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Keith Richardson ,  Phillip Robert Bennett ,  David Alan Macintyre ,  Pamela Pruski

IPC: H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US11239066B2

公开(公告)日：2022-02-01

申请号：US15555694

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US11133164B2

公开(公告)日：2021-09-28

申请号：US16778423

申请日：2020-01-31

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Lajos Godorhazy ,  Daniel Simon ,  Daniel Szalay ,  Zoltan Takats ,  Tamas Karancsi

IPC: H01J49/04 ,  G01N33/483 ,  G01N21/31 ,  G01N21/65

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.